Cellular and Molecular Biology Letters 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The micro-743a-3p-GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
CONCLUSIONS: Chronic alcohol consumption-induced upregulation of GSTM1 in the liver provides a feedback protection against hepatic steatosis and liver injury by counteracting ASK1 activation. Down-regulation of miR-743a-3p improves alcohol intake-induced hepatic steatosis and liver injury via direct targeting on GSTM1. The miR-743a-3p-GSTM1 axis functions as an innate protective pathway to defend the early stage of ALD.PMID:38475733 | PMC:PMC10936097 | DOI:10.1186/s11658-024-00557-x (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 13, 2024 Category: Biochemistry Authors: Tiantian Xu Yan Pan Qinchao Ding Feiwei Cao Kaixin Chang Jiannan Qiu Hui Zhuge Liuyi Hao Haibin Wei Caijuan Si Xiaobing Dou Songtao Li Source Type: research
The micro-743a-3p-GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
CONCLUSIONS: Chronic alcohol consumption-induced upregulation of GSTM1 in the liver provides a feedback protection against hepatic steatosis and liver injury by counteracting ASK1 activation. Down-regulation of miR-743a-3p improves alcohol intake-induced hepatic steatosis and liver injury via direct targeting on GSTM1. The miR-743a-3p-GSTM1 axis functions as an innate protective pathway to defend the early stage of ALD.PMID:38475733 | PMC:PMC10936097 | DOI:10.1186/s11658-024-00557-x (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 13, 2024 Category: Biochemistry Authors: Tiantian Xu Yan Pan Qinchao Ding Feiwei Cao Kaixin Chang Jiannan Qiu Hui Zhuge Liuyi Hao Haibin Wei Caijuan Si Xiaobing Dou Songtao Li Source Type: research
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
This study, guided by the genomic sequence patterns of HPV, established a multiplex recombinase polymerase amplification (RPA) technology based on the concept of "universal primers." This approach achieved the multiple amplification of RPA, coupled with the CRISPR/Cas12a system serving as a medium for signal amplification and conversion. The study successfully constructed a POCT combined detection system, denoted as H-MRC12a (HPV-Multiple RPA-CRISPR/Cas12a), and applied it to high-risk HPV typing detection. The system accomplished the typing detection of six high-risk HPV types (16, 18, 31, 33, 35, and 45) can be completed...
Source: Cellular and Molecular Biology Letters - March 8, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
This study, guided by the genomic sequence patterns of HPV, established a multiplex recombinase polymerase amplification (RPA) technology based on the concept of "universal primers." This approach achieved the multiple amplification of RPA, coupled with the CRISPR/Cas12a system serving as a medium for signal amplification and conversion. The study successfully constructed a POCT combined detection system, denoted as H-MRC12a (HPV-Multiple RPA-CRISPR/Cas12a), and applied it to high-risk HPV typing detection. The system accomplished the typing detection of six high-risk HPV types (16, 18, 31, 33, 35, and 45) can be completed...
Source: Cellular and Molecular Biology Letters - March 8, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
This study, guided by the genomic sequence patterns of HPV, established a multiplex recombinase polymerase amplification (RPA) technology based on the concept of "universal primers." This approach achieved the multiple amplification of RPA, coupled with the CRISPR/Cas12a system serving as a medium for signal amplification and conversion. The study successfully constructed a POCT combined detection system, denoted as H-MRC12a (HPV-Multiple RPA-CRISPR/Cas12a), and applied it to high-risk HPV typing detection. The system accomplished the typing detection of six high-risk HPV types (16, 18, 31, 33, 35, and 45) can be completed...
Source: Cellular and Molecular Biology Letters - March 8, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
This study, guided by the genomic sequence patterns of HPV, established a multiplex recombinase polymerase amplification (RPA) technology based on the concept of "universal primers." This approach achieved the multiple amplification of RPA, coupled with the CRISPR/Cas12a system serving as a medium for signal amplification and conversion. The study successfully constructed a POCT combined detection system, denoted as H-MRC12a (HPV-Multiple RPA-CRISPR/Cas12a), and applied it to high-risk HPV typing detection. The system accomplished the typing detection of six high-risk HPV types (16, 18, 31, 33, 35, and 45) can be completed...
Source: Cellular and Molecular Biology Letters - March 8, 2024 Category: Biochemistry Authors: Yan Liu Zhujun Chao Wei Ding Tanfeng Fang Xinxian Gu Man Xue Wei Wang Rong Han Wanping Sun Source Type: research
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Cell Mol Biol Lett. 2024 Mar 6;29(1):33. doi: 10.1186/s11658-024-00538-0.ABSTRACTGut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organ...
Source: Cellular and Molecular Biology Letters - March 6, 2024 Category: Biochemistry Authors: Menatallah Rayan Tahseen S Sayed Ola J Hussein Lubna Therachiyil Zaid H Maayah Cristina Maccalli Shahab Uddin Jochen H M Prehn Hesham M Korashy Source Type: research
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Cell Mol Biol Lett. 2024 Mar 6;29(1):33. doi: 10.1186/s11658-024-00538-0.ABSTRACTGut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organ...
Source: Cellular and Molecular Biology Letters - March 6, 2024 Category: Biochemistry Authors: Menatallah Rayan Tahseen S Sayed Ola J Hussein Lubna Therachiyil Zaid H Maayah Cristina Maccalli Shahab Uddin Jochen H M Prehn Hesham M Korashy Source Type: research
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Cell Mol Biol Lett. 2024 Mar 6;29(1):33. doi: 10.1186/s11658-024-00538-0.ABSTRACTGut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organ...
Source: Cellular and Molecular Biology Letters - March 6, 2024 Category: Biochemistry Authors: Menatallah Rayan Tahseen S Sayed Ola J Hussein Lubna Therachiyil Zaid H Maayah Cristina Maccalli Shahab Uddin Jochen H M Prehn Hesham M Korashy Source Type: research
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
Cell Mol Biol Lett. 2024 Mar 5;29(1):32. doi: 10.1186/s11658-024-00556-y.ABSTRACTRNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid-protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications of their binding RNA partners, and thereby modulate various physiological and pathological processes. CUG-BP, Elav-like family 1 (CELF1) is a member of the CELF family of RBPs with high affinity to the GU-rich elements in mRNA, and thus exerting control ove...
Source: Cellular and Molecular Biology Letters - March 5, 2024 Category: Biochemistry Authors: Wan-Jia Qin Jin-Jin Shi Ru-Yi Chen Chang-Yun Li Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jia-Feng Cao Jiong Chen Source Type: research
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
CONCLUSIONS: Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.PMID:38439028 | PMC:PMC10910703 | DOI:10.1186/s11658-024-00553-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 4, 2024 Category: Biochemistry Authors: Zhixia Song Yao Xia Lang Shi Hongchu Zha Jing Huang Xiaohong Xiang Huiming Li Hua Huang Ruchi Yue Hongtao Wang Jiefu Zhu Source Type: research
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
CONCLUSIONS: Dysfunction of mitochondrial dynamics mediated by Drp1 contributes to renal IRI. The specific inhibitor of Drp1, P110, demonstrated protective effects in both in vivo and in vitro models of AKI.PMID:38439028 | DOI:10.1186/s11658-024-00553-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 4, 2024 Category: Biochemistry Authors: Zhixia Song Yao Xia Lang Shi Hongchu Zha Jing Huang Xiaohong Xiang Huiming Li Hua Huang Ruchi Yue Hongtao Wang Jiefu Zhu Source Type: research
Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
Cell Mol Biol Lett. 2024 Mar 2;29(1):29. doi: 10.1186/s11658-024-00552-2.ABSTRACTMalignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential tumor-suppressive properties by regulating oncogenes and tumor suppressor genes, microRNAs are important player in melanoma development and progression. We defined the loss of miR-101-3p expression in melanoma cells compared with melanocytes and melanoblast-related cells as an early event in tumor development and aimed to understand the tumor suppressive role of miR-101-3p and its regulation of im...
Source: Cellular and Molecular Biology Letters - March 2, 2024 Category: Biochemistry Authors: Lisa L ämmerhirt Melanie Kappelmann-Fenzl Stefan Fischer Paula Meier Sebastian Staebler Silke Kuphal Anja-Katrin Bosserhoff Source Type: research
Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies
Cell Mol Biol Lett. 2024 Mar 2;29(1):30. doi: 10.1186/s11658-024-00551-3.ABSTRACTExosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or injured cells can have detrimental effects on recipient cells, while exosomes derived from stem cells not only facilitate the repair and regeneration of damaged tissues but also inhibit inflammation and provide protective effects against various diseases, suggesting they may serve as an alternative strategy of stem cells transplantation. Exosomes have a fundamental role in communication between ce...
Source: Cellular and Molecular Biology Letters - March 2, 2024 Category: Biochemistry Authors: Zeinab Vahidinia Abolfazl Azami Tameh Shirin Barati Melika Izadpanah Elahe Seyed Hosseini Source Type: research
Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
Cell Mol Biol Lett. 2024 Mar 2;29(1):29. doi: 10.1186/s11658-024-00552-2.ABSTRACTMalignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential tumor-suppressive properties by regulating oncogenes and tumor suppressor genes, microRNAs are important player in melanoma development and progression. We defined the loss of miR-101-3p expression in melanoma cells compared with melanocytes and melanoblast-related cells as an early event in tumor development and aimed to understand the tumor suppressive role of miR-101-3p and its regulation of im...
Source: Cellular and Molecular Biology Letters - March 2, 2024 Category: Biochemistry Authors: Lisa L ämmerhirt Melanie Kappelmann-Fenzl Stefan Fischer Paula Meier Sebastian Staebler Silke Kuphal Anja-Katrin Bosserhoff Source Type: research
