N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2'-O methylation

CONCLUSIONS: This study identified an oncofetal lncRNA MIR4435-2HG, characterized the role of MIR4435-2HG/NOP58 in stemness maintenance and proliferation of HCC cells, and confirmed m6A as a 'driver' that reactivated MR4435-2HG expression in HCC.PMID:37891494 | PMC:PMC10612268 | DOI:10.1186/s11658-023-00493-2

Source: Cellular and Molecular Biology Letters - October 27, 2023 Category: Biochemistry Authors: Yiqing Zhu Bang Xiao Meng Liu Meiting Chen Ningqi Xia Haiyan Guo Jinfeng Huang Zhiyong Liu Fang Wang Source Type: research