Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis

CONCLUSIONS: Our research is the first to report that circPan3 has an antihypertrophic effect in cardiomyocytes and revealed a novel circPan3-modulated signalling pathway involved in cardiac hypertrophy. CircPan3 inhibits cardiac hypertrophy by targeting the miR-320-3p/HSP20 axis and is regulated by ALKBH5-mediated N6-methylation. This pathway could provide potential therapeutic targets for cardiac hypertrophy.PMID:38172650 | DOI:10.1186/s11658-023-00520-2
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Source Type: research