Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro
Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders this stability is lost, either due to mutations in collagens or in the ch... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 30, 2020 Category: Cytology Authors: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop and Ar ánzazu del Campo Tags: Research article Source Type: research
LncRNA MALAT1 exhibits positive effects on nucleus pulposus cell biology in vivo and in vitro by sponging miR-503
Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 30, 2020 Category: Cytology Authors: Hongyu Zheng, Tingting Wang, Xiangmin Li, Wei He, Zhiqiang Gong, Zhenkai Lou, Bing Wang and Xingguo Li Tags: Research article Source Type: research
Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling
Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bu... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 27, 2020 Category: Cytology Authors: Liye Chen, Lili Wei, Qiongyang Yu, Haozhe Shi and George Liu Tags: Research article Source Type: research
Molecular effects of dADD1 misexpression in chromatin organization and transcription
dADD1 and dXNP proteins are the orthologs in Drosophila melanogaster of the ADD and SNF2 domains, respectively, of the ATRX vertebrate ’s chromatin remodeler, they suppress position effect variegation phenotypes a... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 23, 2020 Category: Cytology Authors: Silvia Meyer-Nava, Amada Torres, Mario Zurita and Viviana Valadez-Graham Tags: Research article Source Type: research
Characterization of the interactions between Codanin-1 and C15Orf41, two proteins implicated in congenital dyserythropoietic anemia type I disease
Congenital dyserythropoietic anemia type I (CDA I), is an autosomal recessive disease with macrocytic anemia in which erythroid precursors in the bone marrow exhibit pathognomonic abnormalities including spong... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 23, 2020 Category: Cytology Authors: Grace Swickley, Yehoshua Bloch, Lidor Malka, Adi Meiri, Sharon Noy-Lotan, Amiel Yanai, Hannah Tamary and Benny Motro Tags: Research article Source Type: research
Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics
In this study, we sought to establish a... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 23, 2020 Category: Cytology Authors: Nastassja L. Kriel, Tiaan Heunis, Samantha L. Sampson, Nico C. Gey van Pittius, Monique J. Williams and Robin M. Warren Tags: Research article Source Type: research
Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells
Tartrate –resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phos... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 18, 2020 Category: Cytology Authors: Anja Reithmeier, Maria Norg ård, Barbro Ek-Rylander, Tuomas Näreoja and Göran Andersson Tags: Research article Source Type: research
Correction to: Binding of Brucella protein, Bp26, to select extracellular matrix molecules
Following publication of the original article [1], an error was reported in the tagging of Eugene H. Johnson and Remya R. Nair in the author group. (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 18, 2020 Category: Cytology Authors: Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi and Eugene H. Johnson Tags: Correction Source Type: research
ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process
Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with regards to the integrin-related mechanosensitive ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 17, 2020 Category: Cytology Authors: David Gagn é, Yannick D. Benoit, Jean-François Groulx, Pierre H. Vachon and Jean-François Beaulieu Tags: Research article Source Type: research
BACE2 degradation is mediated by both the proteasome and lysosome pathways
Alzheimer ’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving en... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 11, 2020 Category: Cytology Authors: Kaixin Qiu, Wenping Liang, Shuai Wang, Tingting Kong, Xin Wang, Chunyan Li, Zhe Wang and Yili Wu Tags: Research article Source Type: research
In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract
Gap junction protein alpha 3 (GJA3), an important pathogenic gene of congenital cataracts, encodes the transmembrane protein connexin46, which functions as an intercellular channel for voltage and chemical gating... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 6, 2020 Category: Cytology Authors: Mingzhou Zhang, Chen Huang, Zhenyu Wang, Huibin Lv and Xuemin Li Tags: Research article Source Type: research
Correction to: Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line
Following publication of the original article [1], the authors reported an error that occurred during the production process. (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 2, 2020 Category: Cytology Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng and Ping Chen Tags: Correction Source Type: research
Systematic optimization of square-wave electroporation conditions for bovine primary fibroblasts
Gene transfer by electroporation is an established method for the non-viral mediated transfection of mammalian cells. Primary cells pose a particular challenge for electroporation-mediated gene transfer, since... (Source: BMC Cell Biology)
Source: BMC Cell Biology - February 28, 2020 Category: Cytology Authors: Iqbal Hyder, Shahin Eghbalsaied and Wilfried A. Kues Tags: Methodology article Source Type: research
A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers
TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - February 28, 2020 Category: Cytology Authors: Jacqueline M. Leung, Eiji Nagayasu, Yu-Chen Hwang, Jun Liu, Phillip G. Pierce, Isabelle Q. Phan, Robin A. Prentice, John M. Murray and Ke Hu Tags: Research article Source Type: research
Identification of universal and cell-type specific p53 DNA binding
The tumor suppressor p53 is a major regulator of the DNA damage response and has been suggested to selectively bind and activate cell-type specific gene expression programs. However recent studies and meta-ana... (Source: BMC Cell Biology)
Source: BMC Cell Biology - February 18, 2020 Category: Cytology Authors: Antonina Hafner, Lyubov Kublo, Michael Tsabar, Galit Lahav and Jacob Stewart-Ornstein Tags: Research article Source Type: research
