Genotype-determined EGFR-RTK heterodimerization and its effects on drug resistance in lung Cancer treatment revealed by molecular dynamics simulations
Epidermal growth factor receptor (EGFR) and its signaling pathways play a vital role in pathogenesis of lung cancer. By disturbing EGFR signaling, mutations of EGFR may lead to progression of cancer or the eme... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 10, 2021 Category: Cytology Authors: Mengxu Zhu, Debby D. Wang and Hong Yan Tags: Research article Source Type: research
Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma
In the present study, fatty acid synthesis is targeted to combat mammary gland carcinoma by activating prolyl hydroxylase-2 with Voacamine alone and in combination with Tamoxifen. It was hypothesized that the ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 5, 2021 Category: Cytology Authors: Lakhveer Singh, Manjari Singh, Shubham Rastogi, Anurag Choudhary, Dinesh Kumar, Ritu Raj, Mohd Nazam Ansari, Abdulaziz S. Saeedan and Gaurav Kaithwas Tags: Research Source Type: research
Methodology for comprehensive cell-level analysis of wound healing experiments using deep learning in MATLAB
Endothelial healing after deployment of cardiovascular devices is particularly important in the context of clinical outcome. It is therefore of great interest to develop tools for a precise prediction of endot... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 2, 2021 Category: Cytology Authors: Jan Oldenburg, Lisa Maletzki, Anne Strohbach, Paul Bell é, Stefan Siewert, Raila Busch, Stephan B. Felix, Klaus-Peter Schmitz and Michael Stiehm Tags: Methodology article Source Type: research
Retraction Note: Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells
(Source: BMC Cell Biology)
Source: BMC Cell Biology - June 1, 2021 Category: Cytology Authors: Liang-Yu Bie, Ning Li, Wen-Ying Deng, Xiao-Yu Lu, Ping Guo and Su-Xia Luo Tags: Retraction Note Source Type: research
sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2 & 9 axis
About 90% of cancer-related deaths are due to metastasis of cancer cells, and angiogenesis is a critical step in this process. sFLT01 is a novel fusion protein and a dual-targeting agent that neutralizes both ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 19, 2021 Category: Cytology Authors: Sepideh Taghizadeh, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Ali Kashanian, Fahimeh Zakeri, Hamid Latifi-Navid and Hoda Shams Najafabadi Tags: Research Source Type: research
Impact of uORFs in mediating regulation of translation in stress conditions
A large fraction of genes contains upstream ORFs (uORFs) in the 5 ′ untranslated region (5’UTR). The translation of uORFs can inhibit the translation of the main coding sequence, for example by causing prematur... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 16, 2021 Category: Cytology Authors: Simone G. Moro, Cedric Hermans, Jorge Ruiz-Orera and M. Mar Alb à Tags: Research Source Type: research
Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study
Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation t... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 10, 2021 Category: Cytology Authors: Elisa Seria, George Galea, Joseph Borg, Kevin Schembri, Gabriella Grech, Sarah Samut Tagliaferro and Alexander Felice Tags: Methodology article Source Type: research
Assessing nucleic acid binding activity of four dinoflagellate cold shock domain proteins from Symbiodinium kawagutii and Lingulodinium polyedra
Dinoflagellates have a generally large number of genes but only a small percentage of these are annotated as transcription factors. Cold shock domain (CSD) containing proteins (CSPs) account for roughly 60% of... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 8, 2021 Category: Cytology Authors: Bahareh Zaheri and David Morse Tags: Research Source Type: research
The Glypican proteoglycans show intrinsic interactions with Wnt-3a in human prostate cancer cells that are not always associated with cascade activation
Prostate cancer occurs through multiple steps until advanced metastasis. Signaling pathways studies can result in the identification of targets to interrupt cancer progression. Glypicans are cell surface prote... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 4, 2021 Category: Cytology Authors: Gabrielle Ferrante Alves de Moraes, Eduardo Listik, Giselle Zenker Justo, Carolina Meloni Vicente and Leny Toma Tags: Research article Source Type: research
SEM and TEM for identification of capsular fibrosis and cellular behavior around breast implants – a descriptive analysis
Capsular fibrosis (CF) is the most common long-term complication in implant-based breast augmentation. It is well accepted that the foreign body response (FBR) instigates the development of fibrotic disease. O... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 3, 2021 Category: Cytology Authors: Britta Kuehlmann, Isabel Zucal, Clark Andrew Bonham, Lydia-Marie Joubert and Lukas Prantl Tags: Methodology article Source Type: research
Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow –derived mesenchymal stem cells by regulating TP63
Progressive population aging has contributed to the increased global prevalence of diabetes and osteoporosis. Inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by hyperglyc... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 27, 2021 Category: Cytology Authors: Fangzi Gong, Le Gao, Luyao Ma, Guangxin Li and Jianhong Yang Tags: Research Source Type: research
Online biophysical predictions for SARS-CoV-2 proteins
The SARS-CoV-2 virus, the causative agent of COVID-19, consists of an assembly of proteins that determine its infectious and immunological behavior, as well as its response to therapeutics. Major structural bi... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 23, 2021 Category: Cytology Authors: Luciano Kagami, Joel Roca-Mart ínez, Jose Gavaldá-García, Pathmanaban Ramasamy, K. Anton Feenstra and Wim F. Vranken Tags: Database Source Type: research
Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center
Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 16, 2021 Category: Cytology Authors: Carina J ägers and Henk Roelink Tags: Research article Source Type: research
Cyr61 promotes Schwann cell proliferation and migration via αvβ3 integrin
Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, S... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 7, 2021 Category: Cytology Authors: Zhenghui Cheng, Yawen Zhang, Yinchao Tian, Yuhan Chen, Fei Ding, Han Wu, Yuhua Ji and Mi Shen Tags: Research article Source Type: research
A cell-based ribozyme reporter system employing a chromosomally-integrated 5 ′ exonuclease gene
Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by bi... (Source: BMC Cell Biology)
Source: BMC Cell Biology - March 16, 2021 Category: Cytology Authors: Aiyada Aroonsri, Jindaporn Kongsee, Jeremy David Gunawan, Daniel Abidin Aubry and Philip James Shaw Tags: Methodology article Source Type: research
