Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line
Interferon-alpha (IFN α) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comp... (Source: BMC Cell Biology)
Source: BMC Cell Biology - February 18, 2020 Category: Cytology Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng and Ping Chen Tags: Research article Source Type: research
Triptolide ameliorates fine particulate matter-induced podocytes injury via regulating NF- κB signaling pathway
PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied. Triptoli... (Source: BMC Cell Biology)
Source: BMC Cell Biology - February 3, 2020 Category: Cytology Authors: Qiang Wan, Zhongyong Liu, Ming Yang, Peng Deng, Nana Tang and Yanwei Liu Tags: Research article Source Type: research
Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development
ZNF143 is an important transcriptional regulator protein conserved in metazoans and estimated to bind over 2000 promoter regions of both messenger RNA and small nuclear RNA genes. The use of zebrafish is a use... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 22, 2020 Category: Cytology Authors: Laura Huning and Gary R. Kunkel Tags: Research article Source Type: research
Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab
Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structu... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 21, 2020 Category: Cytology Authors: Merc è Farràs, Ramón Román, Marc Camps, Joan Miret, Óscar Martínez, Xavier Pujol, Antoni Casablancas and Jordi Joan Cairó Tags: Research article Source Type: research
Trophoblast cell differentiation in the bovine placenta: differentially expressed genes between uninucleate trophoblast cells and trophoblast giant cells are involved in the composition and remodeling of the extracellular matrix and O-glycan biosynthesis
In the bovine placenta, intimate fetomaternal contacts are restricted to discrete placentomes. Here, widely branched fetal chorionic villi interdigitate with corresponding maternal caruncular crypts. The fetal... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 17, 2020 Category: Cytology Authors: Marina Polei, Juliane G ünther, Dirk Koczan and Rainer Fürbass Tags: Research article Source Type: research
Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells
PAX8 was not only a mitotic factor, but identified as a transcription factor involved in the prognosis of human tumor patients. Elucidating the function of PAX8 on the pathology of stomach cancer was meaningful. (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 27, 2019 Category: Cytology Authors: Liang-Yu Bie, Ning Li, Wen-Ying Deng, Xiao-Yu Lu, Ping Guo and Su-Xia Luo Tags: Research article Source Type: research
Prediction of novel mouse TLR9 agonists using a random forest approach
Toll-like receptor 9 is a key innate immune receptor involved in detecting infectious diseases and cancer. TLR9 activates the innate immune system following the recognition of single-stranded DNA oligonucleoti... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 20, 2019 Category: Cytology Authors: Varun Khanna, Lei Li, Johnson Fung, Shoba Ranganathan and Nikolai Petrovsky Tags: Research Source Type: research
Bigram-PGK: phosphoglycerylation prediction using the technique of bigram probabilities of position specific scoring matrix
The biological process known as post-translational modification (PTM) is a condition whereby proteomes are modified that affects normal cell biology, and hence the pathogenesis. A number of PTMs have been disc... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 20, 2019 Category: Cytology Authors: Abel Chandra, Alok Sharma, Abdollah Dehzangi, Daichi Shigemizu and Tatsuhiko Tsunoda Tags: Research Source Type: research
Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies
Multicellular entities like mammalian tissues or microbial biofilms typically exhibit complex spatial arrangements that are adapted to their specific functions or environments. These structures result from int... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 19, 2019 Category: Cytology Authors: Jukka Intosalmi, Adrian C. Scott, Michelle Hays, Nicholas Flann, Olli Yli-Harja, Harri L ähdesmäki, Aimée M. Dudley and Alexander Skupin Tags: Research Article Source Type: research
DUF3669, a “domain of unknown function” within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression
ZNF746 and ZNF777 belong to a subset of the large Kr üppel-associated box (KRAB) zinc finger (ZNF) transcription factor family. They contain, like four other members in human, an additional conserved domain, th... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 19, 2019 Category: Cytology Authors: Mohannad Al Chiblak, Felix Steinbeck, Hans-J ürgen Thiesen and Peter Lorenz Tags: Research article Source Type: research
Prediction of acid radical ion binding residues by K-nearest neighbors classifier
Proteins perform their functions by interacting with acid radical ions. Recently, it was a challenging work to precisely predict the binding residues of acid radical ion ligands in the research field of molecu... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 11, 2019 Category: Cytology Authors: Liu Liu, Xiuzhen Hu, Zhenxing Feng, Xiaojin Zhang, Shan Wang, Shuang Xu and Kai Sun Tags: Research Source Type: research
Recognizing ion ligand binding sites by SMO algorithm
In many important life activities, the execution of protein function depends on the interaction between proteins and ligands. As an important protein binding ligand, the identification of the binding site of t... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 11, 2019 Category: Cytology Authors: Shan Wang, Xiuzhen Hu, Zhenxing Feng, Xiaojin Zhang, Liu Liu, Kai Sun and Shuang Xu Tags: Research Source Type: research
Aurora A site specific TACC3 phosphorylation regulates astral microtubule assembly by stabilizing γ-tubulin ring complex
Astral microtubules emanating from the mitotic centrosomes play pivotal roles in defining cell division axis and tissue morphogenesis. Previous studies have demonstrated that human transforming acidic coiled-c... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 10, 2019 Category: Cytology Authors: Resmi Rajeev, Puja Singh, Ananya Asmita, Ushma Anand and Tapas K. Manna Tags: Research article Source Type: research
Binding of Brucella protein, Bp26, to select extracellular matrix molecules
Brucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis of Brucella adherence to host cells. In the present study, the possible rol... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 29, 2019 Category: Cytology Authors: Yasmin ElTahir, Amna Al-Araimi, Remya R. Nair, Kaija J. Autio, Hongmin Tu, Jack C. Leo, Waleed Al-Marzooqi and Eugene H. Johnson Tags: Research article Source Type: research
Detection of 8-oxoguanine and apurinic/apyrimidinic sites using a fluorophore-labeled probe with cell-penetrating ability
Reactive oxygen species (ROS) produce different lesions in DNA by ROS-induced DNA damage. Detection and quantification of 8-oxo-7,8-dihydroguanine (8-oxoG) within cells are important for study. Human ribosomal... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 27, 2019 Category: Cytology Authors: Dong Min Kang, Jong-Il Shin, Ji Beom Kim, Kyungho Lee, Ji Hyung Chung, Hye-Won Yang, Kil-Nam Kim and Ye Sun Han Tags: Research article Source Type: research
