Chromatin structure in cancer
In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains, an... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 28, 2022 Category: Cytology Authors: Meng Wang, Benjamin D. Sunkel, William C. Ray and Benjamin Z. Stanton Tags: Review Source Type: research
Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells
The non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is ubiquitously expressed in many types of cells. In T cells, the Nck1 isoform promotes T cell receptor signalling as well as acti... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 28, 2022 Category: Cytology Authors: Aussanee Nuiyen, Araya Rattanasri, Piyamaporn Wipa, Sittiruk Roytrakul, Apirath Wangteeraprasert, Sutatip Pongcharoen and Jutaporn Ngoenkam Tags: Research Source Type: research
lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p
Dysregulation of ACTA2-AS1 and miR-532-5p and their functions in various cancers have been widely reported. Their potential of serving as biomarkers in triple-negative breast cancer (TNBC) remains unknown. Thi... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 27, 2022 Category: Cytology Authors: Yi Peng, Xiaoxi Huang and Hongmei Wang Tags: Research Source Type: research
Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing
The single-cell platform provided revolutionary way to study cellular biology. Technologically, a sophistic protocol of isolating qualified single cells would be key to deliver to single-cell platform, which r... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 26, 2022 Category: Cytology Authors: Manman Gao, Peng Guo, Xizhe Liu, Penghui Zhang, Zhongyuan He, Liru Wen, Shaoyu Liu, Zhiyu Zhou and Weimin Zhu Tags: Research article Source Type: research
IDPsBind: a repository of binding sites for intrinsically disordered proteins complexes with known 3D structures
Intrinsically disordered proteins (IDPs) lack a stable three-dimensional structure under physiological conditions but play crucial roles in many biological processes. Intrinsically disordered proteins perform ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 26, 2022 Category: Cytology Authors: CanZhuang Sun, YongE Feng and GuoLiang Fan Tags: Database Source Type: research
Angiogenic ability of human endothelial cells was decreased following senescence induction with hydrogen peroxide: possible role of vegfr-2/akt-1 signaling pathway
Many attempts are used to discover mechanisms driving impaired angiogenesis in age-related diseases. Angiogenesis is highly regulated by different signaling pathways. Here, we investigated the angiogenesis pot... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 25, 2022 Category: Cytology Authors: Nesa Janamo Berenjabad, Vahid Nejati and Jafar Rezaie Tags: Research Source Type: research
Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells
Lubricin, a proteoglycan encoded by the PRG4 gene, is synthesised by superficial zone (SFZ) chondrocytes and synovial cells. It reduces friction between joints and allows smooth sliding of tendons. Although lubri... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 23, 2022 Category: Cytology Authors: Takashi Satake, Shingo Komura, Hitomi Aoki, Akihiro Hirakawa, Yuuki Imai and Haruhiko Akiyama Tags: Research Source Type: research
High D-glucose levels induce ACE2 expression via GLUT1 in human airway epithelial cell line Calu-3
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell by binding to angiotensin-converting enzyme 2 (ACE2) receptors. ACE2 is expressed on human airway epithelial cells. Increased A... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 15, 2022 Category: Cytology Authors: Yoshitaka Wakabayashi, Shin Nakayama, Ai Yamamoto and Takatoshi Kitazawa Tags: Research Source Type: research
MicroRNA-145-5p modulates Kr üppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma
In several human cancers, Kr üppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinom... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 14, 2022 Category: Cytology Authors: Chien-Han Yuan, Wei-Chi Hsu, A.-Mei Huang, Ben-Chih Yuan, I.-Hung Chen, Chia-An Hsu, Rong-Feng Chen, Yih-Min Chu, Hui-Hui Lin and Hung-Lung Ke Tags: Research Source Type: research
Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells
Tunneling nanotubes (TNTs) are special membrane structures for intercellular communications. Vital cargoes (such as mitochondria) could be delivered from healthy cells to rescue damaged ones through TNTs. The ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 6, 2022 Category: Cytology Authors: Chia-Wei Lee, Chia-Chen Kuo, Chi-Jung Liang, Huei-Jyuan Pan, Chia-Ning Shen and Chau-Hwang Lee Tags: Research Source Type: research
Hik28-dependent and Hik28-independent ABC transporters were revealed by proteome-wide analysis of ΔHik28 under combined stress
Synechocystis histidine kinase, Sll0474: Hik28, a signal protein in a two-component signal transduction system, plays a critical role in responding to a decrease in growth temperature and is also involved in nit... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 6, 2022 Category: Cytology Authors: Pavinee Kurdrid, Rayakorn Yutthanasirikul, Sirilak Saree, Jittisak Senachak, Monpaveekorn Saelee and Apiradee Hongsthong Tags: Research Source Type: research
Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma
This study investigated the clinical ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 30, 2022 Category: Cytology Authors: Kun Wang, Jian He, Changling Tu, Hui Xu, Xugang Zhang, Yongchang Lv and Chao Song Tags: Research Source Type: research
Decreased Kr üppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells
Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, the specific regulatory mechanism of decidualization in adenomyosis and ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 27, 2022 Category: Cytology Authors: Jie Mei, Xiaoqiang Sheng, Yuan Yan, Xinyu Cai, Chunxue Zhang, Jiao Tian, Mei Zhang, Jidong Zhou, Huizhi Shan and Chenyang Huang Tags: Research Source Type: research
Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor
Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transforme... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 25, 2022 Category: Cytology Authors: Lena Sophie Behrendsen, Priyanka Rajeev Menon, Muhammad Jawad Khan, Anke Gregus, Oliver Wirths, Thomas Meyer and Julia Staab Tags: Research Source Type: research
OSGIN2 regulates osteogenesis of jawbone BMSCs in osteoporotic rats
Augmentation of oxidative stress after estrogen deficiency leading to functional deficiency of jawbone bone marrow mesenchymal stem cells (BMSCs) causes jawbone loss in osteoporosis. OSGIN2, an oxidative stres... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 21, 2022 Category: Cytology Authors: Yi Shuai, Bingyao Liu, Liang Rong, Bingyi Shao, Bo Chen and Lei Jin Tags: Research Source Type: research
