Molecular docking and machine learning analysis of Abemaciclib in colon cancer
The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised o... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 8, 2020 Category: Cytology Authors: Jose Li ñares-Blanco, Cristian R. Munteanu, Alejandro Pazos and Carlos Fernandez-Lozano Tags: Research article Source Type: research
Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms
Methotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic pregnancy. As reported, MTX has side effects on gastrointestinal system, ner... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 3, 2020 Category: Cytology Authors: Ning Tian, Dan-yu Lv, Ji Yu and Wan-yun Ma Tags: Research article Source Type: research
Identification of a druggable binding pocket in the spike protein reveals a key site for existing drugs potentially capable of combating Covid-19 infectivity
Following the recent outbreak of the new coronavirus pandemic (Covid-19), the rapid determination of the structure of the homo-trimeric spike glycoprotein has prompted the study reported here. The aims were to... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 1, 2020 Category: Cytology Authors: Elliot D. Drew and Robert W. Janes Tags: Research article Source Type: research
Glutant βase: a database for improving the rational design of glucose-tolerant β-glucosidases
Β-glucosidases are key enzymes used in second-generation biofuel production. They act in the last step of the lignocellulose saccharification, converting cellobiose in glucose. However, most of the β-glucosida... (Source: BMC Cell Biology)
Source: BMC Cell Biology - July 1, 2020 Category: Cytology Authors: Diego Mariano, Naiara Pantuza, Lucianna H. Santos, Rafael E. O. Rocha, Leonardo H. F. de Lima, Lucas Bleicher and Raquel Cardoso de Melo-Minardi Tags: Database Source Type: research
Exosomal miR-200c-3p negatively regulates the migration and invasion of lipopolysaccharide (LPS)-stimulated colorectal cancer (CRC)
Colorectal cancer (CRC) is a leading cancer and a major cause of death. Lipopolysaccharide (LPS), an abundant component in gut microbiome, is involved in CRC progression and metastasis, potentially through reg... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 29, 2020 Category: Cytology Authors: Yimei Jiang, Xiaopin Ji, Kun Liu, Yiqing Shi, Changgang Wang, You Li, Tao Zhang, Yonggang He, Ming Xiang and Ren Zhao Tags: Research article Source Type: research
Exosomal miR-200c-3p negatively regulates the migraion and invasion of lipopolysaccharide (LPS)-stimulated colorectal cancer (CRC)
Colorectal cancer (CRC) is a leading cancer and a major cause of death. Lipopolysaccharide (LPS), an abundant component in gut microbiome, is involved in CRC progression and metastasis, potentially through reg... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 29, 2020 Category: Cytology Authors: Yimei Jiang, Xiaopin Ji, Kun Liu, Yiqing Shi, Changgang Wang, You Li, Tao Zhang, Yonggang He, Ming Xiang and Ren Zhao Tags: Research article Source Type: research
Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines
Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degene... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 26, 2020 Category: Cytology Authors: Bernadette Jeremiasse, Csaba Matta, Christopher R. Fellows, David J. Boocock, Julia R. Smith, Susan Liddell, Floris Lafeber, Willem E. van Spil and Ali Mobasheri Tags: Research article Source Type: research
Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease
Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 23, 2020 Category: Cytology Authors: Pierre Laville, Sandrine Fartek, Natacha Cerisier, Delphine Flatters, Michel Petitjean and Leslie Regad Tags: Research article Source Type: research
Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells
Klotho is a multifunctional protein, which exists both in a membrane bound and a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response, and renal fibrosis, thus regulatio... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 22, 2020 Category: Cytology Authors: Yan Li, Yong Liu, Kailong Wang, Yinghui Huang, Wenhao Han, Jiachuan Xiong, Ke Yang, Mingying Liu, Tangli Xiao, Chi Liu, Ting He, Xianjin Bi, Jingbo Zhang, Bo Zhang and Jinghong Zhao Tags: Research article Source Type: research
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes
Trace elements function as essential cofactors that are involved in various biochemical processes in mammals. Autophagy is vital for nutrient supplement, which is an important Zeitegber for the circadian homeosta... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 19, 2020 Category: Cytology Authors: Yicheng Jiang, Yang Gu, Hai Xu, Xiaoyi Tian, Xuefeng Zhang, Xiaojin Xu, Wenting Yan and Xiwen Zhang Tags: Research article Source Type: research
Revealing the key point of the temperature stress response of Arthrospira platensis C1 at the interconnection of C- and N- metabolism by proteome analyses and PPI networking
Growth-temperature stress causes biochemical changes in the cells and reduction of biomass yield. Quantitative proteome of Arthrospira platensis C1 in response to low- and high temperature stresses was previously... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 12, 2020 Category: Cytology Authors: Pavinee Kurdrid, Phutnichar Phuengcharoen, Jittisak Senachak, Sirilak Saree and Apiradee Hongsthong Tags: Research article Source Type: research
The local hypothalamic –pituitary–adrenal axis in cultured human dermal papilla cells
Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotr... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 10, 2020 Category: Cytology Authors: Eun Young Lee, You Jin Nam, Sangjin Kang, Eun Ju Choi, Inbo Han, Jinwan Kim, Dong Hyun Kim, Ji Hae An, Sunghou Lee, Min Ho Lee and Ji Hyung Chung Tags: Research article Source Type: research
Substance P enhances the local activation of NK1R-expressing c-kit+ cardiac progenitor cells in right atrium of ischemia/reperfusion-injured heart
Localization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK1R ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - June 9, 2020 Category: Cytology Authors: Yun-Mi Jeong, Xian Wu Cheng, Kyung Hye Lee, Sora Lee, Haneul Cho and Weon Kim Tags: Research article Source Type: research
Functional analyses of miRNA-146b-5p during myogenic proliferation and differentiation in chicken myoblasts
In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, and more efficient animal pro... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 29, 2020 Category: Cytology Authors: Jeong Hyo Lee, Seo Woo Kim, Ji Seon Han, Seung Pyo Shin, Sang In Lee and Tae Sub Park Tags: Research article Source Type: research
Tbx2 mediates dorsal patterning and germ layer suppression through inhibition of BMP/GDF and Activin/Nodal signaling
Members of the T-box family of DNA-binding proteins play a prominent role in the differentiation of the three primary germ layers. VegT, Brachyury, and Eomesodermin function as transcriptional activators and, ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - May 28, 2020 Category: Cytology Authors: Shoshana Reich, Peter Kayastha, Sushma Teegala and Daniel C. Weinstein Tags: Research article Source Type: research
