Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils
Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood. The aim of this study is to characterize Tau s... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 12, 2020 Category: Cytology Authors: Andr é Marreiro, Kristof Van Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo-Rodriguez, Jan R. T. van Weering, Debby Van Dam, Peter P. De Deyn, Adrian Apetri, Liliane Schoofs and Marc H. Mercken Tags: Research article Source Type: research
Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression
Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fib... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 10, 2020 Category: Cytology Authors: Qiang Chen, Jiuyang Jiao, Youyuan Wang, Zhihui Mai, Jing Ren, Sijie He, Xiaolan Li and Zheng Chen Tags: Research article Source Type: research
Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
Non-professional phagocytosis is usually triggered by stimuli such as necrotic cell death. In tumor therapy, the tumors often disappear slowly and only long time after the end of therapy. Here, tumor therapy i... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 7, 2020 Category: Cytology Authors: Dorian Gottwald, Florian Putz, Nora Hohmann, Maike B üttner-Herold, Markus Hecht, Rainer Fietkau and Luitpold Distel Tags: Research article Source Type: research
LncRNA IMFlnc1 promotes porcine intramuscular adipocyte adipogenesis by sponging miR-199a-5p to up-regulate CAV-1
Local Chinese local pig breeds have thinner muscle fiber and higher intramuscular-fat (IMF) content. But its regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (l... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 4, 2020 Category: Cytology Authors: Jing Wang, Ming-yue Chen, Jun-feng Chen, Qiao-ling Ren, Jia-qing Zhang, Hai Cao, Bao-song Xing and Chuan-ying Pan Tags: Research article Source Type: research
Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes
Neutralising antibodies to sclerostin (Scl-Ab) have shown significant potential to induce bone formation and decrease bone resorption, increase strength and substantially reduce fracture risk in animal studies... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 4, 2020 Category: Cytology Authors: H. Allison, G. Holdsworth and L. M. McNamara Tags: Research article Source Type: research
Polymerization of Bacillus subtilis MreB on a lipid membrane reveals lateral co-polymerization of MreB paralogs and strong effects of cations on filament formation
MreB is a bacterial ortholog of actin and forms mobile filaments underneath the cell membrane, perpendicular to the long axis of the cell, which play a crucial role for cell shape maintenance. We wished to vis... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 4, 2020 Category: Cytology Authors: Simon Dersch, Christian Reimold, Joshua Stoll, Hannes Breddermann, Thomas Heimerl, Herv é Joel Defeu Soufo and Peter L. Graumann Tags: Research article Source Type: research
A novel cell permeability assay for macromolecules
Many cell permeabilisation methods to mediate internalisation of various molecules to mammalian or bacterial cells have been developed. However, no size-specific permeability assay suitable for both cell types... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 30, 2020 Category: Cytology Authors: Yensi Flores Bueso, Sidney Walker, Jennifer Quinn and Mark Tangney Tags: Methodology article Source Type: research
IL6/sIL6R regulates TNF α-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms
The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a dir... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 30, 2020 Category: Cytology Authors: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jes ús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado and José L. Pablos Tags: Research article Source Type: research
MazEF-rifampicin interaction suggests a mechanism for rifampicin induced inhibition of persisters
Persistence is a natural phenomenon whereby a subset of a population of isogenic bacteria either grow slow or become dormant conferring them with the ability to withstand various stresses including antibiotics... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 27, 2020 Category: Cytology Authors: Cyrus Alexander, Ankeeta Guru, Pinkilata Pradhan, Sunanda Mallick, Nimai Charan Mahanandia, Bharat Bhusan Subudhi and Tushar Kant Beuria Tags: Research article Source Type: research
Correction to: Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells
An amendment to this paper has been published and can be accessed via the original article. (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 21, 2020 Category: Cytology Authors: Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng Tags: Correction Source Type: research
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 14, 2020 Category: Cytology Authors: Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix and Lucio Comai Tags: Research article Source Type: research
ESCRT machinery plays a role in microautophagy in yeast
Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 7, 2020 Category: Cytology Authors: Shamsul Morshed, Most Naoshia Tasnin and Takashi Ushimaru Tags: Research article Source Type: research
LncRNA LUCAT1/miR-181a-5p axis promotes proliferation and invasion of breast cancer via targeting KLF6 and KLF15
In this study, we aimed to explore the role of LUCAT1 i... (Source: BMC Cell Biology)
Source: BMC Cell Biology - September 30, 2020 Category: Cytology Authors: Yun Liu, Teng Cheng, Yaying Du, Xiaopeng Hu and Wenfei Xia Tags: Research article Source Type: research
Selecting suitable reference genes for qPCR normalization: a comprehensive analysis in MCF-7 breast cancer cell line
MCF-7 breast cancer cell line is undoubtedly amongst the most extensively studied patient-derived research models, providing pivotal results that have over the decades translated to constantly improving patien... (Source: BMC Cell Biology)
Source: BMC Cell Biology - September 25, 2020 Category: Cytology Authors: Nityanand Jain, Dina Nitisa, Valdis Pirsko and Inese Cakstina Tags: Research article Source Type: research
Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12 –1-9,11 cluster and HCMV miR-US33
G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological ro... (Source: BMC Cell Biology)
Source: BMC Cell Biology - September 24, 2020 Category: Cytology Authors: Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh and Perumal Vivekanandan Tags: Research article Source Type: research
