IL6/sIL6R regulates TNF α-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a dir...

Source: BMC Cell Biology - October 30, 2020 Category: Cytology Authors: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jes ús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado and José L. Pablos Tags: Research article Source Type: research