Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
Human ether- à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue p... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 7, 2021 Category: Cytology Authors: Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada and Masanori Osawa Tags: Research article Source Type: research
New genotypes of Helicobacter Pylori VacA d-region identified from global strains
Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 7, 2021 Category: Cytology Authors: Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu, Chao Zhang, Huai-Ming Sang, Yan-Yan Liu, Guo-Xin Zhang, Jian-Xia Jiang and Shun-Fu Xu Tags: Research article Source Type: research
A novel method for isolation and culture of primary swine gastric epithelial cells
Culturing primary epithelial cells has a major advantage over tumor-derived or immortalized cell lines as long as their functional phenotype and genetic makeup are mainly maintained. The swine model has shown ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 6, 2021 Category: Cytology Authors: Henry Bautista-Amorocho, Jorge Alexander Silva-Sayago, Diego A. Goyeneche-Patino, Tania Liseth P érez-Cala, Fabio Macías-Gómez, Juan Carlos Arango-Viana and Alonso Martínez Tags: Methodology article Source Type: research
Reduced translation efficiency due to novel splicing variants in 5 ′ untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2
Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and d... (Source: BMC Cell Biology)
Source: BMC Cell Biology - January 6, 2021 Category: Cytology Authors: Yasunaga Yoshikawa, Hajime Kozuma, Masami Morimatsu, Kaori Sugawara and Koichi Orino Tags: Research article Source Type: research
A fast, efficient and high-throughput procedure involving laser microdissection and RT droplet digital PCR for tissue-specific expression profiling of rice roots
In rice, the cortex and outer tissues play a key role in submergence tolerance. The cortex differentiates into aerenchyma, which are air-containing cavities that allow the flow of oxygen from shoots to roots, ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 10, 2020 Category: Cytology Authors: Thibault Mounier, Sergi Navarro-Sanz, Charlotte Bureau, Lefeuvre Antoine, Fabrice Varoquaux, Franz Durandet and Christophe P érin Tags: Methodology article Source Type: research
Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein
The CD4 protein is an important surface marker of T lymphocytes, which can mediate the antigen presentation process by interacting with MHC II and TCR molecules in human and mouse. (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 9, 2020 Category: Cytology Authors: Weiya Zhang, Juan Ni, Jie Zhang, Lu Zhang, Huanhuan Zhou, Changzhi Zhao, Mengjin Zhu, Haiyan Wang, Jianlin Han, Xinyun Li and Shuhong Zhao Tags: Research article Source Type: research
Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition
The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymoge... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 7, 2020 Category: Cytology Authors: Izanara C. Pritsch, Irina G. Tikhonova, Heather L. Jewhurst, Orla Drysdale, Krystyna Cwiklinski, Marcelo B. Molento, John P. Dalton and Carolina De M. Verissimo Tags: Research article Source Type: research
Designing a chimeric subunit vaccine for influenza virus, based on HA2, M2e and CTxB: a bioinformatics study
Type A influenza viruses are contagious and even life-threatening if left untreated. So far, no broadly protective vaccine is available due to rapid antigenic changes and emergence of new subtypes of influenza... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 4, 2020 Category: Cytology Authors: Davod Jafari, Sara Malih, Mohammad Mahmoudi Gomari, Marzieh Safari, Rasool Jafari and Mohammad Morad Farajollahi Tags: Research article Source Type: research
An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs
Popeye domain-containing proteins 1 and 2 (POPDC1 and POPDC2) are transmembrane proteins involved in cyclic AMP-mediated signalling processes and are required for normal cardiac pacemaking and conduction. In o... (Source: BMC Cell Biology)
Source: BMC Cell Biology - December 1, 2020 Category: Cytology Authors: Ian Holt, Heidi R. Fuller, Roland F. R. Schindler, Sally L. Shirran, Thomas Brand and Glenn E. Morris Tags: Research article Source Type: research
Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase
Like most major enzyme families, the M14 family of metallocarboxypeptidases (MCPs) contains a number of pseudoenzymes predicted to lack enzyme activity and with poorly characterized molecular function. The gen... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 30, 2020 Category: Cytology Authors: R. Christian McDonald, Matthew J. Schott, Temitope A. Idowu and Peter J. Lyons Tags: Research article Source Type: research
A novel in vitro Caenorhabditis elegans transcription system
Caenorhabditis elegans is an excellent model organism for biological research, but its contributions to biochemical elucidation of eukaryotic transcription mechanisms have been limited. One of the biggest obstacl... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 30, 2020 Category: Cytology Authors: Phillip Wibisono, Yiyong Liu and Jingru Sun Tags: Methodology article Source Type: research
Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs; liver resident macrophages) form the body ’s most effective scavenger cell system for the removal of harmful blood-borne substances, ranging fr... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 27, 2020 Category: Cytology Authors: Sabin Bhandari, Ruomei Li, Jaione Sim ón-Santamaría, Peter McCourt, Steinar Daae Johansen, Bård Smedsrød, Inigo Martinez-Zubiaurre and Karen Kristine Sørensen Tags: Research article Source Type: research
The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture
Maintenance of centrosome number in cells is essential for accurate distribution of chromosomes at mitosis and is dependent on both proper centrosome duplication during interphase and their accurate distributi... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 25, 2020 Category: Cytology Authors: Alan-Michael Bresch, Nadiya Yerich, Rong Wang and Ann O. Sperry Tags: Research article Source Type: research
Regulatory effect of heat shock transcription factor-1 gene on heat shock proteins and its transcriptional regulation analysis in small abalone Haliotis diversicolor
The effects of diverse stresses ultimately alter the structures and functions of proteins. As molecular chaperones, heat shock proteins (HSPs) are a group of highly conserved proteins that help in the refoldin... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 24, 2020 Category: Cytology Authors: Xin Zhang, Yuting Li, Yulong Sun, Mingxing Guo, Jianjun Feng, Yilei Wang and Ziping Zhang Tags: Research article Source Type: research
Identification of biomarkers for the accurate and sensitive diagnosis of three bacterial pneumonia pathogens using in silico approaches
Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A fe... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 20, 2020 Category: Cytology Authors: Olalekan Olanrewaju Bakare, Marshall Keyster and Ashley Pretorius Tags: Research article Source Type: research
