Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche
Mesenchymal stromal cells in the endosteal niche lining compact bone (CB-MSCs) represent a heterogeneous population, all of which contribute to bone repair and remodelling. Hyperglycaemia associated with type ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 21, 2019 Category: Cytology Authors: Ahmed Makki A. Al-Qarakhli, Norhayati Yusop, Rachel J. Waddington and Ryan Moseley Tags: Research article Source Type: research
Design and structural characterisation of olfactomedin-1 variants as tools for functional studies
Olfactomedin-1 (Olfm1; also known as Noelin or Pancortin) is a highly-expressed secreted brain and retina protein and its four isoforms have different roles in nervous system development and function. Structur... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 14, 2019 Category: Cytology Authors: Matti F. Pronker, Hugo van den Hoek and Bert J. C. Janssen Tags: Research article Source Type: research
lncRNA H19 promotes matrix mineralization through up-regulating IGF1 by sponging miR-185-5p in osteoblasts
Matrix mineralization is a key stage in bone formation involving in many bone-specific genes and signaling pathways. Emerging evidence indicate that long non-coding RNA (lncRNA) and microRNAs (miRNAs) play cru... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 12, 2019 Category: Cytology Authors: Yuan Wu, Yu Jiang, Qiang Liu and Cui-Zhong Liu Tags: Research article Source Type: research
Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer
Several reports indicated that the expression of Yes-associated protein (YAP) was associated with multi-drug resistance. Acidic microenvironment increased by the overexpression of vacuolar-ATPase (V-ATPase) wa... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 12, 2019 Category: Cytology Authors: Jing He, Xiao-Yan Shi, Zhi-min Li, Xiao-hua Pan, Ze-Lian Li, Ying Chen, Shi-Jie Yan and Lan Xiao Tags: Research article Source Type: research
Fibrin γ/γ' influences the secretion of fibrinolytic components and clot structure
In healthy subjects fibrinogen γ/γ‘ circulates at 8–15% of the total plasma fibrinogen concentration. Elevated levels of this variant have been associated with arterial thrombosis, and its diminution with veno... (Source: BMC Cell Biology)
Source: BMC Cell Biology - November 1, 2019 Category: Cytology Authors: Miriam Cantero, H éctor Rojas, Eduardo Anglés-Cano and Rita Marchi Tags: Research article Source Type: research
LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21/caspase-8
It was reported that microRNA-21(miR-21) was differentially expressed in the keratinocytes of psoriasis patients, and it may influence the apoptosis and proliferation of cells. The role of lncRNA maternally ex... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 28, 2019 Category: Cytology Authors: Hai-Yan Jia, Kai Zhang, Wen-Jing Lu, Gui-Wen Xu, Jian-Fen Zhang and Zhan-Li Tang Tags: Research article Source Type: research
De novo transcriptome sequencing of radish (Raphanus sativus L.) fleshy roots: analysis of major genes involved in the anthocyanin synthesis pathway
The HongXin radish (Raphanus sativus L.), which contains the natural red pigment (red radish pigment), is grown in the Fuling district of Chongqing City. However, the molecular mechanisms underlying anthocyanin s... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 23, 2019 Category: Cytology Authors: Jian Gao, Wen-Bo Li, Hong-Fang Liu and Fa-Bo Chen Tags: Research article Source Type: research
Construction of strains to identify novel factors for regulation of centromeric cohesion protection (CCP) and sister kinetochore mono-orientation (SKM)
Meiosis-I is a unique type of chromosome segregation where each chromosome aligns and segregates from its homolog. The mechanism of meiosis I homolog separation in different eukaryotes depends on their centrom... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 22, 2019 Category: Cytology Authors: Akhilendra Pratap Bharati and Santanu Kumar Ghosh Tags: Methodology article Source Type: research
Remote homology searches identify bacterial homologues of eukaryotic lipid transfer proteins, including Chorein-N domains in TamB and AsmA and Mdm31p
All cells rely on lipids for key functions. Lipid transfer proteins allow lipids to exit the hydrophobic environment of bilayers, and cross aqueous spaces. One lipid transfer domain fold present in almost all ... (Source: BMC Cell Biology)
Source: BMC Cell Biology - October 14, 2019 Category: Cytology Authors: Timothy P. Levine Tags: Research article Source Type: research
Using parallelized incremental meta-docking can solve the conformational sampling issue when docking large ligands to proteins
Docking large ligands, and especially peptides, to protein receptors is still considered a challenge in computational structural biology. Besides the issue of accurately scoring the binding modes of a protein-... (Source: BMC Cell Biology)
Source: BMC Cell Biology - September 5, 2019 Category: Cytology Authors: Didier Devaurs, Dinler A Antunes, Sarah Hall-Swan, Nicole Mitchell, Mark Moll, Gregory Liz ée and Lydia E Kavraki Tags: Research article Source Type: research
Comparison of polymerization and structural behavior of microtubules in rat brain and sperm affected by the extremely low-frequency electromagnetic field
Microtubule proteins are able to produce electromagnetic fields and have an important role in memory formation, and learning. Therefore, microtubules have the potential to be affected by exogenous electromagne... (Source: BMC Cell Biology)
Source: BMC Cell Biology - August 29, 2019 Category: Cytology Authors: Dariush Gholami, Gholamhossein Riazi, Rouhollah Fathi, Mohsen Sharafi and Abdolhossein Shahverdi Tags: Research article Source Type: research
Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine
The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate in... (Source: BMC Cell Biology)
Source: BMC Cell Biology - August 28, 2019 Category: Cytology Authors: Guillermo A. Videla-Richardson, Ver ónica A. Furmento, Carolina P. Garcia, Olivia Morris-Hanon, Gustavo E. Sevlever, Leonardo Romorini and María E. Scassa Tags: Research article Source Type: research
Improved homology modeling of the human & rat EP4 prostanoid receptors
The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and... (Source: BMC Cell Biology)
Source: BMC Cell Biology - August 27, 2019 Category: Cytology Authors: Melissa C. Holt, Chi S. Ho, M. In és Morano, Stephen D. Barrett and Adam J. Stein Tags: Research article Source Type: research
The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells
Flotillin-2 (Flot2) is a lipid raft scaffold protein that is thought to be related to neural differentiation. Flot2 is phosphorylated by Fyn, a Src kinase, and causes raft-dependent endocytosis; however, the e... (Source: BMC Cell Biology)
Source: BMC Cell Biology - August 27, 2019 Category: Cytology Authors: Kei Hanafusa and Nobuhiro Hayashi Tags: Research article Source Type: research
NFE2/miR-423-5p/TFF1 axis regulates high glucose-induced apoptosis in retinal pigment epithelial cells
A study has shown that miR-423-5p is highly expressed in proliferative diabetic retinopathy. However, the exact biological functions and mechanisms of miR-423-5p in diabetic retinopathy (DR) progression are cu... (Source: BMC Cell Biology)
Source: BMC Cell Biology - August 27, 2019 Category: Cytology Authors: Qing Xiao, Yinu Zhao, Jia Xu, Wen-Jie Li, Yu Chen and Hong-Jing Sun Tags: Research article Source Type: research
