Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10072-9. Online ahead of print.ABSTRACTDisruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revealed that tissue fibroblasts exhibit a remarkable heterogeneity with aging and in age-related diseases. Excessive stress and inflammatory insults induce the differentiation of fibroblasts in...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Antero Salminen Source Type: research
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive r...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Alain Chebly Charbel Khalil Alexandra Kuzyk Marie Beylot-Barry Edith Chevret Source Type: research
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10072-9. Online ahead of print.ABSTRACTDisruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revealed that tissue fibroblasts exhibit a remarkable heterogeneity with aging and in age-related diseases. Excessive stress and inflammatory insults induce the differentiation of fibroblasts in...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Antero Salminen Source Type: research
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive r...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Alain Chebly Charbel Khalil Alexandra Kuzyk Marie Beylot-Barry Edith Chevret Source Type: research
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10072-9. Online ahead of print.ABSTRACTDisruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revealed that tissue fibroblasts exhibit a remarkable heterogeneity with aging and in age-related diseases. Excessive stress and inflammatory insults induce the differentiation of fibroblasts in...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Antero Salminen Source Type: research
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive r...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Alain Chebly Charbel Khalil Alexandra Kuzyk Marie Beylot-Barry Edith Chevret Source Type: research
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10072-9. Online ahead of print.ABSTRACTDisruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revealed that tissue fibroblasts exhibit a remarkable heterogeneity with aging and in age-related diseases. Excessive stress and inflammatory insults induce the differentiation of fibroblasts in...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Antero Salminen Source Type: research
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive r...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Alain Chebly Charbel Khalil Alexandra Kuzyk Marie Beylot-Barry Edith Chevret Source Type: research
