Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet
In this study, we explored the impact of trans fatty acid (TFA) consumption on the overall health and lifespan of male Drosophila melanogaster under an isocaloric high-sugar and high-fat diet. Our results indicate that TFA intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in flies fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, TFA exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies. Collectively, chronic TFA consumption expedites the aging process and reduces the lifespan of male Drosophila melan...
Source: Biogerontology - April 6, 2024 Category: Geriatrics Authors: Qianhua Yuan Mengliu Luo Yutong Xie Wanhan Song Ya Wang Dazhang Deng Shuyan Chen Honghui Guo Source Type: research
Telomeres and aging: on and off the planet!
Biogerontology. 2024 Apr;25(2):313-327. doi: 10.1007/s10522-024-10098-7. Epub 2024 Apr 6.ABSTRACTImproving human healthspan in our rapidly aging population has never been more imperative. Telomeres, protective "caps" at the ends of linear chromosomes, are essential for maintaining genome stability of eukaryotic genomes. Due to their physical location and the "end-replication problem" first envisioned by Dr. Alexey Olovnikov, telomeres shorten with cell division, the implications of which are remarkably profound. Telomeres are hallmarks and molecular drivers of aging, as well as fundamental integrating components of the cum...
Source: Biogerontology - April 6, 2024 Category: Geriatrics Authors: Christopher E Mason Maria A Sierra Henry J Feng Susan M Bailey Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect
This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 μM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resi...
Source: Biogerontology - March 29, 2024 Category: Geriatrics Authors: Hye-Yeon Lee Ji-Hyeon Lee Jisun Baek Kyung A Cho Kyung-Jin Min Source Type: research
The potential use of nanozyme in aging and age-related diseases
Biogerontology. 2024 Mar 11. doi: 10.1007/s10522-024-10095-w. Online ahead of print.ABSTRACTThe effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the p...
Source: Biogerontology - March 11, 2024 Category: Geriatrics Authors: Amirsasan Gorgzadeh Paria Arab Amiri Saman Yasamineh Basim Kareem Naser Khairia Abdulrahman Abdulallah Source Type: research
The potential use of nanozyme in aging and age-related diseases
Biogerontology. 2024 Mar 11. doi: 10.1007/s10522-024-10095-w. Online ahead of print.ABSTRACTThe effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the p...
Source: Biogerontology - March 11, 2024 Category: Geriatrics Authors: Amirsasan Gorgzadeh Paria Arab Amiri Saman Yasamineh Basim Kareem Naser Khairia Abdulrahman Abdulallah Source Type: research
The potential use of nanozyme in aging and age-related diseases
Biogerontology. 2024 Mar 11. doi: 10.1007/s10522-024-10095-w. Online ahead of print.ABSTRACTThe effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the p...
Source: Biogerontology - March 11, 2024 Category: Geriatrics Authors: Amirsasan Gorgzadeh Paria Arab Amiri Saman Yasamineh Basim Kareem Naser Khairia Abdulrahman Abdulallah Source Type: research
The potential use of nanozyme in aging and age-related diseases
Biogerontology. 2024 Mar 11. doi: 10.1007/s10522-024-10095-w. Online ahead of print.ABSTRACTThe effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the p...
Source: Biogerontology - March 11, 2024 Category: Geriatrics Authors: Amirsasan Gorgzadeh Paria Arab Amiri Saman Yasamineh Basim Kareem Naser Khairia Abdulrahman Abdulallah Source Type: research
The potential use of nanozyme in aging and age-related diseases
Biogerontology. 2024 Mar 11. doi: 10.1007/s10522-024-10095-w. Online ahead of print.ABSTRACTThe effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the p...
Source: Biogerontology - March 11, 2024 Category: Geriatrics Authors: Amirsasan Gorgzadeh Paria Arab Amiri Saman Yasamineh Basim Kareem Naser Khairia Abdulrahman Abdulallah Source Type: research
The potential use of nanozyme in aging and age-related diseases
Biogerontology. 2024 Mar 11. doi: 10.1007/s10522-024-10095-w. Online ahead of print.ABSTRACTThe effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the p...
Source: Biogerontology - March 11, 2024 Category: Geriatrics Authors: Amirsasan Gorgzadeh Paria Arab Amiri Saman Yasamineh Basim Kareem Naser Khairia Abdulrahman Abdulallah Source Type: research
