The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Biogerontology. 2023 Sep 25. doi: 10.1007/s10522-023-10068-5. Online ahead of print.ABSTRACTCellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart ...
Source: Biogerontology - September 25, 2023 Category: Geriatrics Authors: Mario Nieto Mina K önisgberg Alejandro Silva-Palacios Source Type: research
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis
Biogerontology. 2023 Sep 22. doi: 10.1007/s10522-023-10064-9. Online ahead of print.ABSTRACTAccumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling due to aging-related secretory phenotypes have been hypothesized to cause age-related skin aging, which results in wrinkles and loss of skin elasticity, thus compromising appearance attractiveness. However, the rejuvenating effects of removing senescent cells from the human skin and the efficacy of related therapeutic agents remain unclear. Here, we investigated the effects of fisetin, a potential anti-aging component found in various edible fruits ...
Source: Biogerontology - September 22, 2023 Category: Geriatrics Authors: Kento Takaya Toru Asou Kazuo Kishi Source Type: research
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis
Biogerontology. 2023 Sep 22. doi: 10.1007/s10522-023-10064-9. Online ahead of print.ABSTRACTAccumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling due to aging-related secretory phenotypes have been hypothesized to cause age-related skin aging, which results in wrinkles and loss of skin elasticity, thus compromising appearance attractiveness. However, the rejuvenating effects of removing senescent cells from the human skin and the efficacy of related therapeutic agents remain unclear. Here, we investigated the effects of fisetin, a potential anti-aging component found in various edible fruits ...
Source: Biogerontology - September 22, 2023 Category: Geriatrics Authors: Kento Takaya Toru Asou Kazuo Kishi Source Type: research
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis
Biogerontology. 2023 Sep 22. doi: 10.1007/s10522-023-10064-9. Online ahead of print.ABSTRACTAccumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling due to aging-related secretory phenotypes have been hypothesized to cause age-related skin aging, which results in wrinkles and loss of skin elasticity, thus compromising appearance attractiveness. However, the rejuvenating effects of removing senescent cells from the human skin and the efficacy of related therapeutic agents remain unclear. Here, we investigated the effects of fisetin, a potential anti-aging component found in various edible fruits ...
Source: Biogerontology - September 22, 2023 Category: Geriatrics Authors: Kento Takaya Toru Asou Kazuo Kishi Source Type: research
Aging adipose tissue, insulin resistance, and type 2 diabetes
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10067-6. Online ahead of print.ABSTRACTWith the increase of population aging, the prevalence of type 2 diabetes (T2D) is also rising. Aging affects the tissues and organs of the whole body, which is the result of various physiological and pathological processes. Adipose tissue has a high degree of plasticity and changes with aging. Aging changes the distribution of adipose tissue, affects adipogenesis, browning characteristics, inflammatory status and adipokine secretion, and increases lipotoxicity. These age-dependent changes in adipose tissue are an important cause of ...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Yixuan Zhao Rensong Yue Source Type: research
Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10066-7. Online ahead of print.ABSTRACTHeat-induced hormesis in longevity is the increase in life span resulting from the previous exposure to a mild heat stress early in life. Here we examined heat-induced hormesis of Drosophila buzzatii in five mass-mating populations, which were derived from five wild populations along an elevation gradient from 202 to 1855 m above sea level in North-Western Argentina. Five day old flies were exposed to 37.5 °C for 90 min to induce hormesis and its possible variation across altitudinal populations. This heat treatment strongly extend...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Mariano Almir ón Federico H Gomez Pablo Sambucetti Fabian M Norry Source Type: research
