Alexey Olovnikov: theoretical biology beyond the margins
Biogerontology. 2023 Sep 7. doi: 10.1007/s10522-023-10061-y. Online ahead of print.ABSTRACTAlexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away...
Source: Biogerontology - September 7, 2023 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
Alexey Olovnikov: theoretical biology beyond the margins
Biogerontology. 2023 Sep 7. doi: 10.1007/s10522-023-10061-y. Online ahead of print.ABSTRACTAlexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away...
Source: Biogerontology - September 7, 2023 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
Alexey Olovnikov: theoretical biology beyond the margins
Biogerontology. 2023 Sep 7. doi: 10.1007/s10522-023-10061-y. Online ahead of print.ABSTRACTAlexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away...
Source: Biogerontology - September 7, 2023 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
Biogerontology. 2023 Aug 30. doi: 10.1007/s10522-023-10059-6. Online ahead of print.ABSTRACTFOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is in...
Source: Biogerontology - August 30, 2023 Category: Geriatrics Authors: Yi-Sheng Khor Pooi-Fong Wong Source Type: research
Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex
Biogerontology. 2023 Aug 29. doi: 10.1007/s10522-023-10056-9. Online ahead of print.ABSTRACTAlong with altering brain responses to stress, aging may also impair recovery from depression symptoms. In the present study, we investigated depressive-like behaviors in young and aged rats and assayed the levels of microRNA-101 (miR-101), Rac1/RhoA, PSD-95, and GluR1 in the prefrontal cortex (PFC) after stress cessation and after a recovery period. Young (3 months old) and aged (22 months old) male Wistar rats were divided into six groups; Young control (YNG), young rats received chronic stress for four weeks (YNG + CS), young rat...
Source: Biogerontology - August 29, 2023 Category: Geriatrics Authors: Arshad Ghaffari-Nasab Gonja Javani Gisou Mohaddes Mohammad Reza Alipour Source Type: research
Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex
Biogerontology. 2023 Aug 29. doi: 10.1007/s10522-023-10056-9. Online ahead of print.ABSTRACTAlong with altering brain responses to stress, aging may also impair recovery from depression symptoms. In the present study, we investigated depressive-like behaviors in young and aged rats and assayed the levels of microRNA-101 (miR-101), Rac1/RhoA, PSD-95, and GluR1 in the prefrontal cortex (PFC) after stress cessation and after a recovery period. Young (3 months old) and aged (22 months old) male Wistar rats were divided into six groups; Young control (YNG), young rats received chronic stress for four weeks (YNG + CS), young rat...
Source: Biogerontology - August 29, 2023 Category: Geriatrics Authors: Arshad Ghaffari-Nasab Gonja Javani Gisou Mohaddes Mohammad Reza Alipour Source Type: research
Telomeres and telomerase: active but complex players in life-history decisions
Biogerontology. 2023 Aug 23. doi: 10.1007/s10522-023-10060-z. Online ahead of print.ABSTRACTStudies on human telomeres have established that telomeres exert a significant influence on lifespan and health of organisms. However, recent research has indicated that the original idea that telomeres affect lifespan in a universal and central manner across all eukaryotic species is an oversimplification. Indeed, findings from a variety of animal species revealed that the role of telomere biology in aging is more subtle and intricate than previously recognized. Here, we show how telomere biology varies depending on the taxon. We a...
Source: Biogerontology - August 23, 2023 Category: Geriatrics Authors: Radmila Čapková Frydrychová Barbora Konopov á Vratislav Peska Miloslav Brejcha Michala S ábová Source Type: research
Telomeres and telomerase: active but complex players in life-history decisions
Biogerontology. 2023 Aug 23. doi: 10.1007/s10522-023-10060-z. Online ahead of print.ABSTRACTStudies on human telomeres have established that telomeres exert a significant influence on lifespan and health of organisms. However, recent research has indicated that the original idea that telomeres affect lifespan in a universal and central manner across all eukaryotic species is an oversimplification. Indeed, findings from a variety of animal species revealed that the role of telomere biology in aging is more subtle and intricate than previously recognized. Here, we show how telomere biology varies depending on the taxon. We a...
Source: Biogerontology - August 23, 2023 Category: Geriatrics Authors: Radmila Čapková Frydrychová Barbora Konopov á Vratislav Peska Miloslav Brejcha Michala S ábová Source Type: research
Telomeres and telomerase: active but complex players in life-history decisions
Biogerontology. 2023 Aug 23. doi: 10.1007/s10522-023-10060-z. Online ahead of print.ABSTRACTStudies on human telomeres have established that telomeres exert a significant influence on lifespan and health of organisms. However, recent research has indicated that the original idea that telomeres affect lifespan in a universal and central manner across all eukaryotic species is an oversimplification. Indeed, findings from a variety of animal species revealed that the role of telomere biology in aging is more subtle and intricate than previously recognized. Here, we show how telomere biology varies depending on the taxon. We a...
Source: Biogerontology - August 23, 2023 Category: Geriatrics Authors: Radmila Čapková Frydrychová Barbora Konopov á Vratislav Peska Miloslav Brejcha Michala S ábová Source Type: research
