Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
Biogerontology. 2023 Jul 17. doi: 10.1007/s10522-023-10046-x. Online ahead of print.ABSTRACTOne of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular mechanisms responsible for the resveratrol antioxidant effect on leukocytes from donors aged between 20 and 80 years old. For this, leukocytes from donors of three age groups (20-39, 40-59 and 60-80) were isolated. Image-iT™LIVE Green Reactive Oxygen Species (ROS) Kit was used. Reactive Nitrogen Species (RNS) analysis was performed by measuring nitric oxide and peroxynitrite. The PKA, Akt/PKB...
Source: Biogerontology - July 17, 2023 Category: Geriatrics Authors: Filipe Nogueira Franco Luciana de Cassia Cardoso B árbara Néllita Moura Silva Glaucy Rodrigues de Ara újo Miriam Martins Chaves Source Type: research
Measuring healthy ageing: current and future tools
Biogerontology. 2023 Jul 13. doi: 10.1007/s10522-023-10041-2. Online ahead of print.ABSTRACTHuman ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies or treatments that can lessen suffering,...
Source: Biogerontology - July 13, 2023 Category: Geriatrics Authors: N ádia Silva Ana Teresa Rajado Filipa Esteves David Brito Joana Apol ónio V ânia Palma Roberto Alexandra Binnie In ês Araújo Cl évio Nóbrega Jos é Bragança Pedro Castelo-Branco ALFAScore Consortium Source Type: research
Measuring healthy ageing: current and future tools
Biogerontology. 2023 Jul 13. doi: 10.1007/s10522-023-10041-2. Online ahead of print.ABSTRACTHuman ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies or treatments that can lessen suffering,...
Source: Biogerontology - July 13, 2023 Category: Geriatrics Authors: N ádia Silva Ana Teresa Rajado Filipa Esteves David Brito Joana Apol ónio V ânia Palma Roberto Alexandra Binnie In ês Araújo Cl évio Nóbrega Jos é Bragança Pedro Castelo-Branco ALFAScore Consortium Source Type: research
Measuring healthy ageing: current and future tools
Biogerontology. 2023 Jul 13. doi: 10.1007/s10522-023-10041-2. Online ahead of print.ABSTRACTHuman ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies or treatments that can lessen suffering,...
Source: Biogerontology - July 13, 2023 Category: Geriatrics Authors: N ádia Silva Ana Teresa Rajado Filipa Esteves David Brito Joana Apol ónio V ânia Palma Roberto Alexandra Binnie In ês Araújo Cl évio Nóbrega Jos é Bragança Pedro Castelo-Branco ALFAScore Consortium Source Type: research
Measuring healthy ageing: current and future tools
Biogerontology. 2023 Jul 13. doi: 10.1007/s10522-023-10041-2. Online ahead of print.ABSTRACTHuman ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and disease risk. Such markers would allow for the targeted implementation of strategies or treatments that can lessen suffering,...
Source: Biogerontology - July 13, 2023 Category: Geriatrics Authors: N ádia Silva Ana Teresa Rajado Filipa Esteves David Brito Joana Apol ónio V ânia Palma Roberto Alexandra Binnie In ês Araújo Cl évio Nóbrega Jos é Bragança Pedro Castelo-Branco ALFAScore Consortium Source Type: research
