Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster
This study considers a scenario in which the piwi and aub genes in the presence of functional hobo transposons can modify the effects from the level of DNA damage to lifespan. The simultaneous presence of mutation (piwi or aub) and hobo (regardless of size) in the genome has practically no effect or (less often) leads to a decrease in the level of DNA damage in ovarian cells. A high level of sterility and low ovarian reserve were noted mainly with a combination of mutations and full-sized hobo elements. The combination of these two genetic factors negatively affects the fertility of young females and embryonic survival. Is...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: Elena Yushkova Source Type: research
Mitochondria and telomeres: hand in glove
Biogerontology. 2023 Oct 21. doi: 10.1007/s10522-023-10074-7. Online ahead of print.ABSTRACTBorn as an endosymbiont, the bacteria engulfed by the proto-eukaryotic cell more than 1.45 billion years ago progressively evolved as an important organelle with multiple interactions with the host cell. In particular, strong connections between mitochondria and the chromosome ends, the telomeres, led to propose a new theory of ageing in which dysfunctional telomeres and mitochondria are the main actors of a vicious circle reducing cell fitness and promoting cellular ageing. We review the evidences that oxidative stress and dysfunct...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: M élina Vaurs Elif Beyza Dolu Anabelle Decottignies Source Type: research
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster
This study considers a scenario in which the piwi and aub genes in the presence of functional hobo transposons can modify the effects from the level of DNA damage to lifespan. The simultaneous presence of mutation (piwi or aub) and hobo (regardless of size) in the genome has practically no effect or (less often) leads to a decrease in the level of DNA damage in ovarian cells. A high level of sterility and low ovarian reserve were noted mainly with a combination of mutations and full-sized hobo elements. The combination of these two genetic factors negatively affects the fertility of young females and embryonic survival. Is...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: Elena Yushkova Source Type: research
Mitochondria and telomeres: hand in glove
Biogerontology. 2023 Oct 21. doi: 10.1007/s10522-023-10074-7. Online ahead of print.ABSTRACTBorn as an endosymbiont, the bacteria engulfed by the proto-eukaryotic cell more than 1.45 billion years ago progressively evolved as an important organelle with multiple interactions with the host cell. In particular, strong connections between mitochondria and the chromosome ends, the telomeres, led to propose a new theory of ageing in which dysfunctional telomeres and mitochondria are the main actors of a vicious circle reducing cell fitness and promoting cellular ageing. We review the evidences that oxidative stress and dysfunct...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: M élina Vaurs Elif Beyza Dolu Anabelle Decottignies Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
The influence of biological sex in human skeletal muscle transcriptome during ageing
In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment analysis software and Molecular Signatures Database were used for functional and enrichment analysis. A protein-protein interaction network was constructed using STRING and visualized in Cytoscape. The results were compared between female and male subgroups. Differentially expressed genes and enriched pathways in different sex subgroups shared only limited similarities. The pathways enriche...
Source: Biogerontology - October 4, 2023 Category: Geriatrics Authors: Xiaoyu Huang Mao Chen Ya Xiao Fangyi Zhu Liying Chen Xiaoyu Tian Li Hong Source Type: research
