An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law
Biogerontology. 2023 Nov 25. doi: 10.1007/s10522-023-10079-2. Online ahead of print.ABSTRACTMuch attention in biogerontology is paid to the deceleration of mortality rate increase with age by the end of a species-specific lifespan, e.g. after ca. 90 years in humans. Being analyzed based on the Gompertz law µ(t)=µ0e^γt with its inbuilt linearity of the dependency of lnµ on t, this is commonly assumed to reflect the heterogeneity of populations where the frailer subjects die out earlier thus increasing the proportions of those whose dying out is slower and leading to decreases in the demographic rates of aging. Using Hum...
Source: Biogerontology - November 25, 2023 Category: Geriatrics Authors: A Golubev Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
