Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Redox signaling and modulation in ageing
Biogerontology. 2023 Aug 3. doi: 10.1007/s10522-023-10055-w. Online ahead of print.ABSTRACTIn spite of considerable progress that has been reached in understanding how reactive oxygen species (ROS) interact with its cellular targets, several important challenges regarding regulatory effects of redox signaling mechanisms remain to be addressed enough in aging and age-related disorders. Redox signaling is precisely regulated in different tissues and subcellular locations. It modulates the homeostatic balance of many regulatory facilities such as cell cycle, circadian rhythms, adapting the external environments, etc. The newl...
Source: Biogerontology - August 3, 2023 Category: Geriatrics Authors: Mehmet Can Atayik Ufuk Çakatay Source Type: research
Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho
Biogerontology. 2023 Jul 31. doi: 10.1007/s10522-023-10054-x. Online ahead of print.ABSTRACTAging is a natural process of gradual decrease in physical and mental capacity. Biological age (accumulation of changes and damage) and chronological age (years lived) may differ. Biological age reflects the risk of various types of disease and death from any cause. We selected potential biomarkers of aging - telomerase, AGEs, GDF11 and 15 (growth differentiation factor 11/15), sirtuin 1, NAD+ (nicotinamide adenine dinucleotide), inflammasome NLRP3, DNA/RNA damage, and klotho to investigate changes in their levels depending on age a...
Source: Biogerontology - July 31, 2023 Category: Geriatrics Authors: Pavel Borsky Drahomira Holmannova Ctirad Andrys Jan Kremlacek Zdenek Fiala Helena Parova Vit Rehacek Tereza Svadlakova Svatopluk Byma Otto Kucera Lenka Borska Source Type: research
Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho
Biogerontology. 2023 Jul 31. doi: 10.1007/s10522-023-10054-x. Online ahead of print.ABSTRACTAging is a natural process of gradual decrease in physical and mental capacity. Biological age (accumulation of changes and damage) and chronological age (years lived) may differ. Biological age reflects the risk of various types of disease and death from any cause. We selected potential biomarkers of aging - telomerase, AGEs, GDF11 and 15 (growth differentiation factor 11/15), sirtuin 1, NAD+ (nicotinamide adenine dinucleotide), inflammasome NLRP3, DNA/RNA damage, and klotho to investigate changes in their levels depending on age a...
Source: Biogerontology - July 31, 2023 Category: Geriatrics Authors: Pavel Borsky Drahomira Holmannova Ctirad Andrys Jan Kremlacek Zdenek Fiala Helena Parova Vit Rehacek Tereza Svadlakova Svatopluk Byma Otto Kucera Lenka Borska Source Type: research
Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho
Biogerontology. 2023 Jul 31. doi: 10.1007/s10522-023-10054-x. Online ahead of print.ABSTRACTAging is a natural process of gradual decrease in physical and mental capacity. Biological age (accumulation of changes and damage) and chronological age (years lived) may differ. Biological age reflects the risk of various types of disease and death from any cause. We selected potential biomarkers of aging - telomerase, AGEs, GDF11 and 15 (growth differentiation factor 11/15), sirtuin 1, NAD+ (nicotinamide adenine dinucleotide), inflammasome NLRP3, DNA/RNA damage, and klotho to investigate changes in their levels depending on age a...
Source: Biogerontology - July 31, 2023 Category: Geriatrics Authors: Pavel Borsky Drahomira Holmannova Ctirad Andrys Jan Kremlacek Zdenek Fiala Helena Parova Vit Rehacek Tereza Svadlakova Svatopluk Byma Otto Kucera Lenka Borska Source Type: research
Differential effects of aging on hippocampal ultrastructure in male vs. female rats
In this study, we sought to determine potential differences in ultrastructural changes between male and female rats at various stages of life. We performed quantitative electron microscopic evaluation of hippocampal CA1 region, an area intimately involved in cognitive behavior, in both male and female adolescent, adult and old Wistar rats. Specifically, we measured the number of docking synaptic vesicles in axo-dendritic synapses, the length of active zone as well as the total number of synaptic vesicles. Distinct age- and sex-dependent effects were observed in several parameters. Thus, adult female rats had the lowest syn...
Source: Biogerontology - July 29, 2023 Category: Geriatrics Authors: Mzia Zhvania Nadezhda Japaridze Yousef Tizabi Nino Lomidze Nino Pochkhidze Fuad Rzayev Eldar Gasimov Source Type: research
