Telomeres, cellular senescence, and aging: past and future
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10085-4. Online ahead of print.ABSTRACTOver half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching consequences of telomeres in the context of aging and age-related diseases. Additionally, the paper investigates the various factors that can infl...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Madeline Eppard Jo ão F Passos Stella Victorelli Source Type: research
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10082-7. Online ahead of print.ABSTRACTFrailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not yet clear. Recent studies have shown that the diversity, composition, and metabolites of gut microbiota significantly changed in older adults wi...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Xiao-Ming Wang Lu Fan Chen-Chen Meng Yun-Jiao Wang Li-E Deng Zhuo Yuan Jun-Ping Zhang Yan-Yang Li Shi-Chao Lv Source Type: research
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10083-6. Online ahead of print.ABSTRACTWorldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of Berberis vulgaris L. extract. Here we show that extract of Berberis vulgaris L. can, depending on concentrate, increases lifespan up to 6%, promote h...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Denis Golubev Elena Platonova Nadezhda Zemskaya Oksana Shevchenko Mikhail Shaposhnikov Polina Nekrasova Sergey Patov Umida Ibragimova Nikita Valuisky Alexander Borisov Xenia Zhukova Svetlana Sorokina Roman Litvinov Alexey Moskalev Source Type: research
Telomeres, cellular senescence, and aging: past and future
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10085-4. Online ahead of print.ABSTRACTOver half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching consequences of telomeres in the context of aging and age-related diseases. Additionally, the paper investigates the various factors that can infl...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Madeline Eppard Jo ão F Passos Stella Victorelli Source Type: research
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10082-7. Online ahead of print.ABSTRACTFrailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not yet clear. Recent studies have shown that the diversity, composition, and metabolites of gut microbiota significantly changed in older adults wi...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Xiao-Ming Wang Lu Fan Chen-Chen Meng Yun-Jiao Wang Li-E Deng Zhuo Yuan Jun-Ping Zhang Yan-Yang Li Shi-Chao Lv Source Type: research
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10083-6. Online ahead of print.ABSTRACTWorldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of Berberis vulgaris L. extract. Here we show that extract of Berberis vulgaris L. can, depending on concentrate, increases lifespan up to 6%, promote h...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Denis Golubev Elena Platonova Nadezhda Zemskaya Oksana Shevchenko Mikhail Shaposhnikov Polina Nekrasova Sergey Patov Umida Ibragimova Nikita Valuisky Alexander Borisov Xenia Zhukova Svetlana Sorokina Roman Litvinov Alexey Moskalev Source Type: research
Telomeres, cellular senescence, and aging: past and future
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10085-4. Online ahead of print.ABSTRACTOver half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching consequences of telomeres in the context of aging and age-related diseases. Additionally, the paper investigates the various factors that can infl...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Madeline Eppard Jo ão F Passos Stella Victorelli Source Type: research
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10082-7. Online ahead of print.ABSTRACTFrailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not yet clear. Recent studies have shown that the diversity, composition, and metabolites of gut microbiota significantly changed in older adults wi...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Xiao-Ming Wang Lu Fan Chen-Chen Meng Yun-Jiao Wang Li-E Deng Zhuo Yuan Jun-Ping Zhang Yan-Yang Li Shi-Chao Lv Source Type: research
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10083-6. Online ahead of print.ABSTRACTWorldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern society. Berberis vulgaris L. fruits serve as a functional food supplement with a high concentration of bioactive compounds, which offer numerous health-promoting benefits. The goal of this study was to investigate the geroprotective effect of Berberis vulgaris L. extract. Here we show that extract of Berberis vulgaris L. can, depending on concentrate, increases lifespan up to 6%, promote h...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Denis Golubev Elena Platonova Nadezhda Zemskaya Oksana Shevchenko Mikhail Shaposhnikov Polina Nekrasova Sergey Patov Umida Ibragimova Nikita Valuisky Alexander Borisov Xenia Zhukova Svetlana Sorokina Roman Litvinov Alexey Moskalev Source Type: research
Telomeres, cellular senescence, and aging: past and future
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10085-4. Online ahead of print.ABSTRACTOver half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching consequences of telomeres in the context of aging and age-related diseases. Additionally, the paper investigates the various factors that can infl...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Madeline Eppard Jo ão F Passos Stella Victorelli Source Type: research
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Biogerontology. 2023 Dec 27. doi: 10.1007/s10522-023-10082-7. Online ahead of print.ABSTRACTFrailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not yet clear. Recent studies have shown that the diversity, composition, and metabolites of gut microbiota significantly changed in older adults wi...
Source: Biogerontology - December 27, 2023 Category: Geriatrics Authors: Xiao-Ming Wang Lu Fan Chen-Chen Meng Yun-Jiao Wang Li-E Deng Zhuo Yuan Jun-Ping Zhang Yan-Yang Li Shi-Chao Lv Source Type: research
Telomere length and cancer risk: finding Goldilocks
Biogerontology. 2023 Dec 18. doi: 10.1007/s10522-023-10080-9. Online ahead of print.ABSTRACTTelomeres are the nucleoprotein complex at chromosome ends essential in genomic stability. Baseline telomere length (TL) is determined by rare and common germline genetic variants but shortens with age and is susceptible to certain environmental exposures. Cellular senescence or apoptosis are normally triggered when telomeres reach a critically short length, but cancer cells overcome these protective mechanisms and continue to divide despite chromosomal instability. Rare germline variants in telomere maintenance genes cause exceedin...
Source: Biogerontology - December 18, 2023 Category: Geriatrics Authors: Sharon A Savage Source Type: research
Application potential of senolytics in clinical treatment
Biogerontology. 2023 Dec 18. doi: 10.1007/s10522-023-10084-5. Online ahead of print.ABSTRACTOf the factors studied in individual ageing, the accumulation of senescent cells has been considered as an essential cause of organ degeneration to eventually initiate age-related diseases. Cellular senescence is attributed to the accumulation of damage for an inducement in the activation of cell cycle inhibitory pathways, resulting the cell permanently withdraw from the cell proliferation cycle. Further, senescent cells will activate the inflammatory factor secretion pathway to promote the development of various age-related disease...
Source: Biogerontology - December 18, 2023 Category: Geriatrics Authors: Tiantian Li Shiyuan Li Kefeng Ma Jinming Kong Source Type: research
Telomere length and cancer risk: finding Goldilocks
Biogerontology. 2023 Dec 18. doi: 10.1007/s10522-023-10080-9. Online ahead of print.ABSTRACTTelomeres are the nucleoprotein complex at chromosome ends essential in genomic stability. Baseline telomere length (TL) is determined by rare and common germline genetic variants but shortens with age and is susceptible to certain environmental exposures. Cellular senescence or apoptosis are normally triggered when telomeres reach a critically short length, but cancer cells overcome these protective mechanisms and continue to divide despite chromosomal instability. Rare germline variants in telomere maintenance genes cause exceedin...
Source: Biogerontology - December 18, 2023 Category: Geriatrics Authors: Sharon A Savage Source Type: research
Application potential of senolytics in clinical treatment
Biogerontology. 2023 Dec 18. doi: 10.1007/s10522-023-10084-5. Online ahead of print.ABSTRACTOf the factors studied in individual ageing, the accumulation of senescent cells has been considered as an essential cause of organ degeneration to eventually initiate age-related diseases. Cellular senescence is attributed to the accumulation of damage for an inducement in the activation of cell cycle inhibitory pathways, resulting the cell permanently withdraw from the cell proliferation cycle. Further, senescent cells will activate the inflammatory factor secretion pathway to promote the development of various age-related disease...
Source: Biogerontology - December 18, 2023 Category: Geriatrics Authors: Tiantian Li Shiyuan Li Kefeng Ma Jinming Kong Source Type: research
