Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes
This study serves as a proof of concept that telomere shortening can effectively induce aging-associated phenotypes, thereby providing a valuable tool to investigate age-related decline and neurodegenerative diseases.PMID:37987889 | DOI:10.1007/s10522-023-10076-5 (Source: Biogerontology)
Source: Biogerontology - November 21, 2023 Category: Geriatrics Authors: Jasmine Harley Munirah Mohamad Santosa Chong Yi Ng Oleg V Grinchuk Jin-Hui Hor Yajing Liang Valerie Jingwen Lim Wee Wei Tee Derrick Sek Tong Ong Shi-Yan Ng Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks
Biogerontology. 2023 Nov 16. doi: 10.1007/s10522-023-10077-4. Online ahead of print.ABSTRACTChronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the ger...
Source: Biogerontology - November 15, 2023 Category: Geriatrics Authors: Elena Sandalova Andrea B Maier Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
Chromosome ends and the theory of marginotomy: implications for reproduction
Biogerontology. 2023 Nov 9. doi: 10.1007/s10522-023-10071-w. Online ahead of print.ABSTRACTTelomeres are the protective structures located at the ends of linear chromosomes. They were first described in the 1930s, but their biology remained unexplored until the early 70s, when Alexey M. Olovnikov, a theoretical biologist, suggested that telomeres cannot be fully copied during DNA replication. He proposed a theory that linked this phenomenon with the limit of cell proliferation capacity and the "duration of life" (theory of marginotomy), and suggested a potential of telomere lenghthening for the prevention of aging (anti-ma...
Source: Biogerontology - November 9, 2023 Category: Geriatrics Authors: Isabel C órdova-Oriz Alba M Polonio Isabel Cuadrado-Torroglosa Luc ía Chico-Sordo Marta Medrano Juan A Garc ía-Velasco Elisa Varela Source Type: research
