Aging adipose tissue, insulin resistance, and type 2 diabetes
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10067-6. Online ahead of print.ABSTRACTWith the increase of population aging, the prevalence of type 2 diabetes (T2D) is also rising. Aging affects the tissues and organs of the whole body, which is the result of various physiological and pathological processes. Adipose tissue has a high degree of plasticity and changes with aging. Aging changes the distribution of adipose tissue, affects adipogenesis, browning characteristics, inflammatory status and adipokine secretion, and increases lipotoxicity. These age-dependent changes in adipose tissue are an important cause of ...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Yixuan Zhao Rensong Yue Source Type: research
Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10066-7. Online ahead of print.ABSTRACTHeat-induced hormesis in longevity is the increase in life span resulting from the previous exposure to a mild heat stress early in life. Here we examined heat-induced hormesis of Drosophila buzzatii in five mass-mating populations, which were derived from five wild populations along an elevation gradient from 202 to 1855 m above sea level in North-Western Argentina. Five day old flies were exposed to 37.5 °C for 90 min to induce hormesis and its possible variation across altitudinal populations. This heat treatment strongly extend...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Mariano Almir ón Federico H Gomez Pablo Sambucetti Fabian M Norry Source Type: research
Aging adipose tissue, insulin resistance, and type 2 diabetes
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10067-6. Online ahead of print.ABSTRACTWith the increase of population aging, the prevalence of type 2 diabetes (T2D) is also rising. Aging affects the tissues and organs of the whole body, which is the result of various physiological and pathological processes. Adipose tissue has a high degree of plasticity and changes with aging. Aging changes the distribution of adipose tissue, affects adipogenesis, browning characteristics, inflammatory status and adipokine secretion, and increases lipotoxicity. These age-dependent changes in adipose tissue are an important cause of ...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Yixuan Zhao Rensong Yue Source Type: research
Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii
Biogerontology. 2023 Sep 19. doi: 10.1007/s10522-023-10066-7. Online ahead of print.ABSTRACTHeat-induced hormesis in longevity is the increase in life span resulting from the previous exposure to a mild heat stress early in life. Here we examined heat-induced hormesis of Drosophila buzzatii in five mass-mating populations, which were derived from five wild populations along an elevation gradient from 202 to 1855 m above sea level in North-Western Argentina. Five day old flies were exposed to 37.5 °C for 90 min to induce hormesis and its possible variation across altitudinal populations. This heat treatment strongly extend...
Source: Biogerontology - September 19, 2023 Category: Geriatrics Authors: Mariano Almir ón Federico H Gomez Pablo Sambucetti Fabian M Norry Source Type: research
Disrupted HSF1 regulation in normal and exceptional brain aging
Biogerontology. 2023 Sep 14. doi: 10.1007/s10522-023-10063-w. Online ahead of print.ABSTRACTBrain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biologica...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Rachana Trivedi Bailey Knopf Sharlene Rakoczy Gunjan D Manocha Holly Brown-Borg Donald A Jurivich Source Type: research
Plasma proteins as potential biomarkers of aging of single tissue and cell type
In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Daigo Okada Source Type: research
Disrupted HSF1 regulation in normal and exceptional brain aging
Biogerontology. 2023 Sep 14. doi: 10.1007/s10522-023-10063-w. Online ahead of print.ABSTRACTBrain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biologica...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Rachana Trivedi Bailey Knopf Sharlene Rakoczy Gunjan D Manocha Holly Brown-Borg Donald A Jurivich Source Type: research
Plasma proteins as potential biomarkers of aging of single tissue and cell type
In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Daigo Okada Source Type: research
Disrupted HSF1 regulation in normal and exceptional brain aging
Biogerontology. 2023 Sep 14. doi: 10.1007/s10522-023-10063-w. Online ahead of print.ABSTRACTBrain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biologica...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Rachana Trivedi Bailey Knopf Sharlene Rakoczy Gunjan D Manocha Holly Brown-Borg Donald A Jurivich Source Type: research
Plasma proteins as potential biomarkers of aging of single tissue and cell type
In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Daigo Okada Source Type: research
Disrupted HSF1 regulation in normal and exceptional brain aging
Biogerontology. 2023 Sep 14. doi: 10.1007/s10522-023-10063-w. Online ahead of print.ABSTRACTBrain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biologica...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Rachana Trivedi Bailey Knopf Sharlene Rakoczy Gunjan D Manocha Holly Brown-Borg Donald A Jurivich Source Type: research
Plasma proteins as potential biomarkers of aging of single tissue and cell type
In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Daigo Okada Source Type: research
Disrupted HSF1 regulation in normal and exceptional brain aging
Biogerontology. 2023 Sep 14. doi: 10.1007/s10522-023-10063-w. Online ahead of print.ABSTRACTBrain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biologica...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Rachana Trivedi Bailey Knopf Sharlene Rakoczy Gunjan D Manocha Holly Brown-Borg Donald A Jurivich Source Type: research
Plasma proteins as potential biomarkers of aging of single tissue and cell type
In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Daigo Okada Source Type: research
Alexey Olovnikov: theoretical biology beyond the margins
Biogerontology. 2023 Sep 7. doi: 10.1007/s10522-023-10061-y. Online ahead of print.ABSTRACTAlexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away...
Source: Biogerontology - September 7, 2023 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
