Telomeres and telomerase: active but complex players in life-history decisions
Biogerontology. 2023 Aug 23. doi: 10.1007/s10522-023-10060-z. Online ahead of print.ABSTRACTStudies on human telomeres have established that telomeres exert a significant influence on lifespan and health of organisms. However, recent research has indicated that the original idea that telomeres affect lifespan in a universal and central manner across all eukaryotic species is an oversimplification. Indeed, findings from a variety of animal species revealed that the role of telomere biology in aging is more subtle and intricate than previously recognized. Here, we show how telomere biology varies depending on the taxon. We a...
Source: Biogerontology - August 23, 2023 Category: Geriatrics Authors: Radmila Čapková Frydrychová Barbora Konopov á Vratislav Peska Miloslav Brejcha Michala S ábová Source Type: research
Telomeres and telomerase: active but complex players in life-history decisions
Biogerontology. 2023 Aug 23. doi: 10.1007/s10522-023-10060-z. Online ahead of print.ABSTRACTStudies on human telomeres have established that telomeres exert a significant influence on lifespan and health of organisms. However, recent research has indicated that the original idea that telomeres affect lifespan in a universal and central manner across all eukaryotic species is an oversimplification. Indeed, findings from a variety of animal species revealed that the role of telomere biology in aging is more subtle and intricate than previously recognized. Here, we show how telomere biology varies depending on the taxon. We a...
Source: Biogerontology - August 23, 2023 Category: Geriatrics Authors: Radmila Čapková Frydrychová Barbora Konopov á Vratislav Peska Miloslav Brejcha Michala S ábová Source Type: research
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D
This study aimed to examine the effects of a high-calorie diet (HCD) with/without vitamin D on BM-MSCs senescence. In the first phase, 48 middle-aged rats were fed a normal chow diet (NCD, n = 24) and an HCD (n = 24) for 26 weeks. Afterward, the rats in each group were randomly divided into three equal subgroups. Immediately, eight-rat from each diet group were sacrificed to assess the HCD effects on the first phase measurements. In the second phase, the remaining 4 groups of rats were fed either NCD or HCD with (6 IU/g) or without vitamin D (standard intake: 1 IU/g); in other words, in this phase, the animals were fed (a)...
Source: Biogerontology - August 22, 2023 Category: Geriatrics Authors: Fahimeh Agh Seyed Hadi Mousavi Naheed Aryaeian Fatemehsadat Amiri Mohammad Reza Jalilvand Motahareh Hasani Farhad Vahid Fatemeh Sepahvand Mehran Vosugh Source Type: research
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D
This study aimed to examine the effects of a high-calorie diet (HCD) with/without vitamin D on BM-MSCs senescence. In the first phase, 48 middle-aged rats were fed a normal chow diet (NCD, n = 24) and an HCD (n = 24) for 26 weeks. Afterward, the rats in each group were randomly divided into three equal subgroups. Immediately, eight-rat from each diet group were sacrificed to assess the HCD effects on the first phase measurements. In the second phase, the remaining 4 groups of rats were fed either NCD or HCD with (6 IU/g) or without vitamin D (standard intake: 1 IU/g); in other words, in this phase, the animals were fed (a)...
Source: Biogerontology - August 22, 2023 Category: Geriatrics Authors: Fahimeh Agh Seyed Hadi Mousavi Naheed Aryaeian Fatemehsadat Amiri Mohammad Reza Jalilvand Motahareh Hasani Farhad Vahid Fatemeh Sepahvand Mehran Vosugh Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10058-7. Online ahead of print.ABSTRACTJingfang Granule (JFG), a traditional Chinese medicine, is frequently employed in clinical settings for the treatment of infectious diseases. Nevertheless, the anti-aging and anti-infection effects of JFG remain uncertain. In the present study, these effects were evaluated using the Caenorhabditis elegans (C. elegans) N2 as a model organism. The results demonstrated that JFG significantly increased the median lifespan of C. elegans by 31.2% at a dosage of 10 mg/mL, without any discernible adverse effects, such as alterations in the ...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Xin Yin Yiwei Meng Chenghong Sun Yanqiu Zhao Weitao Wang Peipei Zhao Mengmeng Wang Jingli Ren Jingchun Yao Lixin Zhang Xuekui Xia Source Type: research
Retinal microvascular complexity as a putative biomarker of biological age: a pilot study
Biogerontology. 2023 Aug 12. doi: 10.1007/s10522-023-10057-8. Online ahead of print.ABSTRACTPhysiological changes associated with aging increase the risk for the development of age-related diseases. This increase is non-specific to the type of age-related disease, although each disease develops through a unique pathophysiologic mechanism. People who age at a faster rate develop age-related diseases earlier in their life. They have an older "biological age" compared to their "chronological age". Early detection of individuals with accelerated aging would allow timely intervention to postpone the onset of age-related disease...
Source: Biogerontology - August 12, 2023 Category: Geriatrics Authors: Natasa Popovic Ma ša Ždralević Stela Vujosevic Miroslav Radunovi ć Antoaneta Ad žić Zečević Isidora Rov čanin Dragović Batri ć Vukčević Tomo Popovic Ljiljana Radulovi ć Tijana Vukovi ć Jevto Erakovi ć Ranko Lazovi ć Miodrag Radunovi ć Source Type: research
