AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10072-9. Online ahead of print.ABSTRACTDisruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revealed that tissue fibroblasts exhibit a remarkable heterogeneity with aging and in age-related diseases. Excessive stress and inflammatory insults induce the differentiation of fibroblasts in...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Antero Salminen Source Type: research
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive r...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Alain Chebly Charbel Khalil Alexandra Kuzyk Marie Beylot-Barry Edith Chevret Source Type: research
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10072-9. Online ahead of print.ABSTRACTDisruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are mesenchymal cells which display an impressive plasticity in the regulation of ECM integrity and thus on tissue homeostasis. Single-cell transcriptome studies have revealed that tissue fibroblasts exhibit a remarkable heterogeneity with aging and in age-related diseases. Excessive stress and inflammatory insults induce the differentiation of fibroblasts in...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Antero Salminen Source Type: research
T-cell lymphocytes' aging clock: telomeres, telomerase and aging
Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive r...
Source: Biogerontology - November 2, 2023 Category: Geriatrics Authors: Alain Chebly Charbel Khalil Alexandra Kuzyk Marie Beylot-Barry Edith Chevret Source Type: research
Methods that shaped telomerase research
Biogerontology. 2023 Oct 31. doi: 10.1007/s10522-023-10073-8. Online ahead of print.ABSTRACTTelomerase, the ribonucleoprotein (RNP) responsible for telomere maintenance, has a complex life. Complex in that it is made of multiple proteins and an RNA, and complex because it undergoes many changes, and passes through different cell compartments. As such, many methods have been developed to discover telomerase components, delve deep into understanding its structure and function and to figure out how telomerase biology ultimately relates to human health and disease. While some old gold-standard methods are still key for determi...
Source: Biogerontology - October 31, 2023 Category: Geriatrics Authors: Louise Bartle Raymund J Wellinger Source Type: research
Methods that shaped telomerase research
Biogerontology. 2023 Oct 31. doi: 10.1007/s10522-023-10073-8. Online ahead of print.ABSTRACTTelomerase, the ribonucleoprotein (RNP) responsible for telomere maintenance, has a complex life. Complex in that it is made of multiple proteins and an RNA, and complex because it undergoes many changes, and passes through different cell compartments. As such, many methods have been developed to discover telomerase components, delve deep into understanding its structure and function and to figure out how telomerase biology ultimately relates to human health and disease. While some old gold-standard methods are still key for determi...
Source: Biogerontology - October 31, 2023 Category: Geriatrics Authors: Louise Bartle Raymund J Wellinger Source Type: research
Methods that shaped telomerase research
Biogerontology. 2023 Oct 31. doi: 10.1007/s10522-023-10073-8. Online ahead of print.ABSTRACTTelomerase, the ribonucleoprotein (RNP) responsible for telomere maintenance, has a complex life. Complex in that it is made of multiple proteins and an RNA, and complex because it undergoes many changes, and passes through different cell compartments. As such, many methods have been developed to discover telomerase components, delve deep into understanding its structure and function and to figure out how telomerase biology ultimately relates to human health and disease. While some old gold-standard methods are still key for determi...
Source: Biogerontology - October 31, 2023 Category: Geriatrics Authors: Louise Bartle Raymund J Wellinger Source Type: research
"Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects" as a form of hormesis: an interview with Professor Sataro Goto
Biogerontology. 2023 Oct 26. doi: 10.1007/s10522-023-10069-4. Online ahead of print.ABSTRACTProfessor Sataro Goto is one of the pioneers of biological aging research in Japan. He is renowned for his work on the role of protein errors and modifications, the accumulation of abnormal proteins due to reduced protein turnover, and the modulation of aging and lifespan by adult-onset dietary restriction and regular exercise. Professor Goto is a remarkably intelligent, visionary, empathetic, humble, and wise man, who kindly agreed to this interview that I (Zsolt Radak) made with him during one of my frequent visits to his labs, in...
Source: Biogerontology - October 26, 2023 Category: Geriatrics Authors: Zsolt Radak Source Type: research
"Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects" as a form of hormesis: an interview with Professor Sataro Goto
Biogerontology. 2023 Oct 26. doi: 10.1007/s10522-023-10069-4. Online ahead of print.ABSTRACTProfessor Sataro Goto is one of the pioneers of biological aging research in Japan. He is renowned for his work on the role of protein errors and modifications, the accumulation of abnormal proteins due to reduced protein turnover, and the modulation of aging and lifespan by adult-onset dietary restriction and regular exercise. Professor Goto is a remarkably intelligent, visionary, empathetic, humble, and wise man, who kindly agreed to this interview that I (Zsolt Radak) made with him during one of my frequent visits to his labs, in...
Source: Biogerontology - October 26, 2023 Category: Geriatrics Authors: Zsolt Radak Source Type: research
"Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects" as a form of hormesis: an interview with Professor Sataro Goto
Biogerontology. 2023 Oct 26. doi: 10.1007/s10522-023-10069-4. Online ahead of print.ABSTRACTProfessor Sataro Goto is one of the pioneers of biological aging research in Japan. He is renowned for his work on the role of protein errors and modifications, the accumulation of abnormal proteins due to reduced protein turnover, and the modulation of aging and lifespan by adult-onset dietary restriction and regular exercise. Professor Goto is a remarkably intelligent, visionary, empathetic, humble, and wise man, who kindly agreed to this interview that I (Zsolt Radak) made with him during one of my frequent visits to his labs, in...
Source: Biogerontology - October 26, 2023 Category: Geriatrics Authors: Zsolt Radak Source Type: research
"Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects" as a form of hormesis: an interview with Professor Sataro Goto
Biogerontology. 2023 Oct 26. doi: 10.1007/s10522-023-10069-4. Online ahead of print.ABSTRACTProfessor Sataro Goto is one of the pioneers of biological aging research in Japan. He is renowned for his work on the role of protein errors and modifications, the accumulation of abnormal proteins due to reduced protein turnover, and the modulation of aging and lifespan by adult-onset dietary restriction and regular exercise. Professor Goto is a remarkably intelligent, visionary, empathetic, humble, and wise man, who kindly agreed to this interview that I (Zsolt Radak) made with him during one of my frequent visits to his labs, in...
Source: Biogerontology - October 26, 2023 Category: Geriatrics Authors: Zsolt Radak Source Type: research
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster
This study considers a scenario in which the piwi and aub genes in the presence of functional hobo transposons can modify the effects from the level of DNA damage to lifespan. The simultaneous presence of mutation (piwi or aub) and hobo (regardless of size) in the genome has practically no effect or (less often) leads to a decrease in the level of DNA damage in ovarian cells. A high level of sterility and low ovarian reserve were noted mainly with a combination of mutations and full-sized hobo elements. The combination of these two genetic factors negatively affects the fertility of young females and embryonic survival. Is...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: Elena Yushkova Source Type: research
Mitochondria and telomeres: hand in glove
Biogerontology. 2023 Oct 21. doi: 10.1007/s10522-023-10074-7. Online ahead of print.ABSTRACTBorn as an endosymbiont, the bacteria engulfed by the proto-eukaryotic cell more than 1.45 billion years ago progressively evolved as an important organelle with multiple interactions with the host cell. In particular, strong connections between mitochondria and the chromosome ends, the telomeres, led to propose a new theory of ageing in which dysfunctional telomeres and mitochondria are the main actors of a vicious circle reducing cell fitness and promoting cellular ageing. We review the evidences that oxidative stress and dysfunct...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: M élina Vaurs Elif Beyza Dolu Anabelle Decottignies Source Type: research
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster
This study considers a scenario in which the piwi and aub genes in the presence of functional hobo transposons can modify the effects from the level of DNA damage to lifespan. The simultaneous presence of mutation (piwi or aub) and hobo (regardless of size) in the genome has practically no effect or (less often) leads to a decrease in the level of DNA damage in ovarian cells. A high level of sterility and low ovarian reserve were noted mainly with a combination of mutations and full-sized hobo elements. The combination of these two genetic factors negatively affects the fertility of young females and embryonic survival. Is...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: Elena Yushkova Source Type: research
Mitochondria and telomeres: hand in glove
Biogerontology. 2023 Oct 21. doi: 10.1007/s10522-023-10074-7. Online ahead of print.ABSTRACTBorn as an endosymbiont, the bacteria engulfed by the proto-eukaryotic cell more than 1.45 billion years ago progressively evolved as an important organelle with multiple interactions with the host cell. In particular, strong connections between mitochondria and the chromosome ends, the telomeres, led to propose a new theory of ageing in which dysfunctional telomeres and mitochondria are the main actors of a vicious circle reducing cell fitness and promoting cellular ageing. We review the evidences that oxidative stress and dysfunct...
Source: Biogerontology - October 21, 2023 Category: Geriatrics Authors: M élina Vaurs Elif Beyza Dolu Anabelle Decottignies Source Type: research
