Telomeres in health and longevity: special issue in memory of Alexey Olovnikov
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-023-10090-7. Online ahead of print.ABSTRACTIn this special issue we commemorate theoretical biologist Alexey Olovnikov (1936-2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging from telomere length dynamics in wild animal populations to problems of telomere maintenance during human space flight.PMID:38441835...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
A comprehensive model for the biochemistry of ageing, senescence and longevity
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-024-10097-8. Online ahead of print.ABSTRACTVarious models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune system, the mammalian target for rapamycin complex, controlling cell growth, and the integrated stress responses, controlling homeostasis. Thi...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Hiskias Gerrit Keizer R Brands Ronald Sake Oosting Willem Seinen Source Type: research
Telomeres in health and longevity: special issue in memory of Alexey Olovnikov
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-023-10090-7. Online ahead of print.ABSTRACTIn this special issue we commemorate theoretical biologist Alexey Olovnikov (1936-2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging from telomere length dynamics in wild animal populations to problems of telomere maintenance during human space flight.PMID:38441835...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
A comprehensive model for the biochemistry of ageing, senescence and longevity
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-024-10097-8. Online ahead of print.ABSTRACTVarious models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune system, the mammalian target for rapamycin complex, controlling cell growth, and the integrated stress responses, controlling homeostasis. Thi...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Hiskias Gerrit Keizer R Brands Ronald Sake Oosting Willem Seinen Source Type: research
Telomeres in health and longevity: special issue in memory of Alexey Olovnikov
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-023-10090-7. Online ahead of print.ABSTRACTIn this special issue we commemorate theoretical biologist Alexey Olovnikov (1936-2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging from telomere length dynamics in wild animal populations to problems of telomere maintenance during human space flight.PMID:38441835...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
A comprehensive model for the biochemistry of ageing, senescence and longevity
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-024-10097-8. Online ahead of print.ABSTRACTVarious models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune system, the mammalian target for rapamycin complex, controlling cell growth, and the integrated stress responses, controlling homeostasis. Thi...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Hiskias Gerrit Keizer R Brands Ronald Sake Oosting Willem Seinen Source Type: research
Telomeres in health and longevity: special issue in memory of Alexey Olovnikov
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-023-10090-7. Online ahead of print.ABSTRACTIn this special issue we commemorate theoretical biologist Alexey Olovnikov (1936-2022), whose theory of marginotomy has laid the foundation for the new field of biology that studies the molecular structure of telomeres and its role in health, longevity and aging. This issue contains a collection of reviews and research articles that discuss different aspects of telomere and telomerase research, ranging from telomere length dynamics in wild animal populations to problems of telomere maintenance during human space flight.PMID:38441835...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Ivan A Olovnikov Source Type: research
A comprehensive model for the biochemistry of ageing, senescence and longevity
Biogerontology. 2024 Mar 5. doi: 10.1007/s10522-024-10097-8. Online ahead of print.ABSTRACTVarious models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and non-coherent portrayal of ageing. Here, we describe a concise and comprehensive model for the biochemistry of ageing consisting of three interacting signalling hubs. These are the nuclear factor kappa B complex (NFκB), controlling the innate immune system, the mammalian target for rapamycin complex, controlling cell growth, and the integrated stress responses, controlling homeostasis. Thi...
Source: Biogerontology - March 5, 2024 Category: Geriatrics Authors: Hiskias Gerrit Keizer R Brands Ronald Sake Oosting Willem Seinen Source Type: research
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging
Biogerontology. 2024 Mar 4. doi: 10.1007/s10522-024-10096-9. Online ahead of print.ABSTRACTAging negatively affects the appearance and texture of the skin owing to the accumulation of senescent fibroblasts within the dermis. Senescent cells undergo abnormal remodeling of collagen and the extracellular matrix through an inflammatory histolytic senescence-associated secretory phenotype (SASP). Therefore, suppression of SASP in senescent cells is essential for the development of effective skin anti-aging therapies. Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5), an extracellular signaling molecule, h...
Source: Biogerontology - March 4, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging
Biogerontology. 2024 Mar 4. doi: 10.1007/s10522-024-10096-9. Online ahead of print.ABSTRACTAging negatively affects the appearance and texture of the skin owing to the accumulation of senescent fibroblasts within the dermis. Senescent cells undergo abnormal remodeling of collagen and the extracellular matrix through an inflammatory histolytic senescence-associated secretory phenotype (SASP). Therefore, suppression of SASP in senescent cells is essential for the development of effective skin anti-aging therapies. Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5), an extracellular signaling molecule, h...
Source: Biogerontology - March 4, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway
This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age. A fibrosis model was created by stimulating skeletal muscle fibroblasts with TGF-β1. The Forelimb grip strength test assessed skeletal muscle function, and expression levels of COL1A1, COL3A1, and α-SMA were analyzed by western blot, qPCR, and immunohistochemistry. Additionally, levels of AMPKα/MMP9/TGFβ1/Smad signaling pathways were examined. In naturally aging mice, skeletal muscle fu...
Source: Biogerontology - February 25, 2024 Category: Geriatrics Authors: Qixuan Huang Jie Chen Siqi Liao Jiangchuan Long Ronghua Fang Yusen He Peiyun Chen Dongfang Liu Source Type: research
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway
This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age. A fibrosis model was created by stimulating skeletal muscle fibroblasts with TGF-β1. The Forelimb grip strength test assessed skeletal muscle function, and expression levels of COL1A1, COL3A1, and α-SMA were analyzed by western blot, qPCR, and immunohistochemistry. Additionally, levels of AMPKα/MMP9/TGFβ1/Smad signaling pathways were examined. In naturally aging mice, skeletal muscle fu...
Source: Biogerontology - February 25, 2024 Category: Geriatrics Authors: Qixuan Huang Jie Chen Siqi Liao Jiangchuan Long Ronghua Fang Yusen He Peiyun Chen Dongfang Liu Source Type: research
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway
This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age. A fibrosis model was created by stimulating skeletal muscle fibroblasts with TGF-β1. The Forelimb grip strength test assessed skeletal muscle function, and expression levels of COL1A1, COL3A1, and α-SMA were analyzed by western blot, qPCR, and immunohistochemistry. Additionally, levels of AMPKα/MMP9/TGFβ1/Smad signaling pathways were examined. In naturally aging mice, skeletal muscle fu...
Source: Biogerontology - February 25, 2024 Category: Geriatrics Authors: Qixuan Huang Jie Chen Siqi Liao Jiangchuan Long Ronghua Fang Yusen He Peiyun Chen Dongfang Liu Source Type: research
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway
This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age. A fibrosis model was created by stimulating skeletal muscle fibroblasts with TGF-β1. The Forelimb grip strength test assessed skeletal muscle function, and expression levels of COL1A1, COL3A1, and α-SMA were analyzed by western blot, qPCR, and immunohistochemistry. Additionally, levels of AMPKα/MMP9/TGFβ1/Smad signaling pathways were examined. In naturally aging mice, skeletal muscle fu...
Source: Biogerontology - February 25, 2024 Category: Geriatrics Authors: Qixuan Huang Jie Chen Siqi Liao Jiangchuan Long Ronghua Fang Yusen He Peiyun Chen Dongfang Liu Source Type: research
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway
This study aims to determine whether empagliflozin can improve skeletal muscle fibrosis induced by sarcopenia in naturally aging mice. A natural aging model was established by feeding male mice from 13 months of age to 19 months of age. A fibrosis model was created by stimulating skeletal muscle fibroblasts with TGF-β1. The Forelimb grip strength test assessed skeletal muscle function, and expression levels of COL1A1, COL3A1, and α-SMA were analyzed by western blot, qPCR, and immunohistochemistry. Additionally, levels of AMPKα/MMP9/TGFβ1/Smad signaling pathways were examined. In naturally aging mice, skeletal muscle fu...
Source: Biogerontology - February 25, 2024 Category: Geriatrics Authors: Qixuan Huang Jie Chen Siqi Liao Jiangchuan Long Ronghua Fang Yusen He Peiyun Chen Dongfang Liu Source Type: research
