Role of sestrins in metabolic and aging-related diseases
Biogerontology. 2023 Jul 30. doi: 10.1007/s10522-023-10053-y. Online ahead of print.ABSTRACTSestrins are a type of highly conserved stress-inducing protein that has antioxidant and mTORC1 inhibitory functions. Metabolic dysfunction and aging are the main risk factors for development of human diseases, such as diabetes, neurodegenerative diseases, and cancer. Sestrins have important roles in regulating glucose and lipid metabolism, anti-tumor functions, and aging by inhibiting the reactive oxygen species and mechanistic target of rapamycin complex 1 pathways. In this review, the structure and biological functions of sestrin...
Source: Biogerontology - July 29, 2023 Category: Geriatrics Authors: Huan Fang Xiaomin Shi Juyi Wan Xiaolin Zhong Source Type: research
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
Biogerontology. 2023 Jul 30. doi: 10.1007/s10522-023-10050-1. Online ahead of print.ABSTRACTAging accompanied by several age-related complications, is a multifaceted inevitable biological progression involving various genetic, environmental, and lifestyle factors. The major factor in this process is oxidative stress, caused by an abundance of reactive oxygen species (ROS) generated in the mitochondria and endoplasmic reticulum (ER). ROS and RNS pose a threat by disrupting signaling mechanisms and causing oxidative damage to cellular components. This oxidative stress affects both the ER and mitochondria, causing proteopathi...
Source: Biogerontology - July 29, 2023 Category: Geriatrics Authors: Mani Raj Chaudhary Sakshi Chaudhary Yogita Sharma Thokchom Arjun Singh Alok Kumar Mishra Shweta Sharma Mohammad Murtaza Mehdi Source Type: research
Differential effects of aging on hippocampal ultrastructure in male vs. female rats
In this study, we sought to determine potential differences in ultrastructural changes between male and female rats at various stages of life. We performed quantitative electron microscopic evaluation of hippocampal CA1 region, an area intimately involved in cognitive behavior, in both male and female adolescent, adult and old Wistar rats. Specifically, we measured the number of docking synaptic vesicles in axo-dendritic synapses, the length of active zone as well as the total number of synaptic vesicles. Distinct age- and sex-dependent effects were observed in several parameters. Thus, adult female rats had the lowest syn...
Source: Biogerontology - July 29, 2023 Category: Geriatrics Authors: Mzia Zhvania Nadezhda Japaridze Yousef Tizabi Nino Lomidze Nino Pochkhidze Fuad Rzayev Eldar Gasimov Source Type: research
Role of sestrins in metabolic and aging-related diseases
Biogerontology. 2023 Jul 30. doi: 10.1007/s10522-023-10053-y. Online ahead of print.ABSTRACTSestrins are a type of highly conserved stress-inducing protein that has antioxidant and mTORC1 inhibitory functions. Metabolic dysfunction and aging are the main risk factors for development of human diseases, such as diabetes, neurodegenerative diseases, and cancer. Sestrins have important roles in regulating glucose and lipid metabolism, anti-tumor functions, and aging by inhibiting the reactive oxygen species and mechanistic target of rapamycin complex 1 pathways. In this review, the structure and biological functions of sestrin...
Source: Biogerontology - July 29, 2023 Category: Geriatrics Authors: Huan Fang Xiaomin Shi Juyi Wan Xiaolin Zhong Source Type: research
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
Biogerontology. 2023 Jul 30. doi: 10.1007/s10522-023-10050-1. Online ahead of print.ABSTRACTAging accompanied by several age-related complications, is a multifaceted inevitable biological progression involving various genetic, environmental, and lifestyle factors. The major factor in this process is oxidative stress, caused by an abundance of reactive oxygen species (ROS) generated in the mitochondria and endoplasmic reticulum (ER). ROS and RNS pose a threat by disrupting signaling mechanisms and causing oxidative damage to cellular components. This oxidative stress affects both the ER and mitochondria, causing proteopathi...
Source: Biogerontology - July 29, 2023 Category: Geriatrics Authors: Mani Raj Chaudhary Sakshi Chaudhary Yogita Sharma Thokchom Arjun Singh Alok Kumar Mishra Shweta Sharma Mohammad Murtaza Mehdi Source Type: research
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Biogerontology. 2023 Jul 24. doi: 10.1007/s10522-023-10051-0. Online ahead of print.NO ABSTRACTPMID:37486569 | DOI:10.1007/s10522-023-10051-0 (Source: Biogerontology)
Source: Biogerontology - July 24, 2023 Category: Geriatrics Authors: Aradhana Prajapati Sidharth Mehan Zuber Khan Source Type: research
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Biogerontology. 2023 Jul 24. doi: 10.1007/s10522-023-10051-0. Online ahead of print.NO ABSTRACTPMID:37486569 | DOI:10.1007/s10522-023-10051-0 (Source: Biogerontology)
Source: Biogerontology - July 24, 2023 Category: Geriatrics Authors: Aradhana Prajapati Sidharth Mehan Zuber Khan Source Type: research
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Biogerontology. 2023 Jul 24. doi: 10.1007/s10522-023-10051-0. Online ahead of print.NO ABSTRACTPMID:37486569 | DOI:10.1007/s10522-023-10051-0 (Source: Biogerontology)
Source: Biogerontology - July 24, 2023 Category: Geriatrics Authors: Aradhana Prajapati Sidharth Mehan Zuber Khan Source Type: research
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Biogerontology. 2023 Jul 24. doi: 10.1007/s10522-023-10051-0. Online ahead of print.NO ABSTRACTPMID:37486569 | DOI:10.1007/s10522-023-10051-0 (Source: Biogerontology)
Source: Biogerontology - July 24, 2023 Category: Geriatrics Authors: Aradhana Prajapati Sidharth Mehan Zuber Khan Source Type: research
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Biogerontology. 2023 Jul 24. doi: 10.1007/s10522-023-10051-0. Online ahead of print.NO ABSTRACTPMID:37486569 | DOI:10.1007/s10522-023-10051-0 (Source: Biogerontology)
Source: Biogerontology - July 24, 2023 Category: Geriatrics Authors: Aradhana Prajapati Sidharth Mehan Zuber Khan Source Type: research
Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
Biogerontology. 2023 Jul 17. doi: 10.1007/s10522-023-10046-x. Online ahead of print.ABSTRACTOne of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular mechanisms responsible for the resveratrol antioxidant effect on leukocytes from donors aged between 20 and 80 years old. For this, leukocytes from donors of three age groups (20-39, 40-59 and 60-80) were isolated. Image-iT™LIVE Green Reactive Oxygen Species (ROS) Kit was used. Reactive Nitrogen Species (RNS) analysis was performed by measuring nitric oxide and peroxynitrite. The PKA, Akt/PKB...
Source: Biogerontology - July 17, 2023 Category: Geriatrics Authors: Filipe Nogueira Franco Luciana de Cassia Cardoso B árbara Néllita Moura Silva Glaucy Rodrigues de Ara újo Miriam Martins Chaves Source Type: research
Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
Biogerontology. 2023 Jul 17. doi: 10.1007/s10522-023-10046-x. Online ahead of print.ABSTRACTOne of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular mechanisms responsible for the resveratrol antioxidant effect on leukocytes from donors aged between 20 and 80 years old. For this, leukocytes from donors of three age groups (20-39, 40-59 and 60-80) were isolated. Image-iT™LIVE Green Reactive Oxygen Species (ROS) Kit was used. Reactive Nitrogen Species (RNS) analysis was performed by measuring nitric oxide and peroxynitrite. The PKA, Akt/PKB...
Source: Biogerontology - July 17, 2023 Category: Geriatrics Authors: Filipe Nogueira Franco Luciana de Cassia Cardoso B árbara Néllita Moura Silva Glaucy Rodrigues de Ara újo Miriam Martins Chaves Source Type: research
Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
Biogerontology. 2023 Jul 17. doi: 10.1007/s10522-023-10046-x. Online ahead of print.ABSTRACTOne of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular mechanisms responsible for the resveratrol antioxidant effect on leukocytes from donors aged between 20 and 80 years old. For this, leukocytes from donors of three age groups (20-39, 40-59 and 60-80) were isolated. Image-iT™LIVE Green Reactive Oxygen Species (ROS) Kit was used. Reactive Nitrogen Species (RNS) analysis was performed by measuring nitric oxide and peroxynitrite. The PKA, Akt/PKB...
Source: Biogerontology - July 17, 2023 Category: Geriatrics Authors: Filipe Nogueira Franco Luciana de Cassia Cardoso B árbara Néllita Moura Silva Glaucy Rodrigues de Ara újo Miriam Martins Chaves Source Type: research
Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
Biogerontology. 2023 Jul 17. doi: 10.1007/s10522-023-10046-x. Online ahead of print.ABSTRACTOne of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular mechanisms responsible for the resveratrol antioxidant effect on leukocytes from donors aged between 20 and 80 years old. For this, leukocytes from donors of three age groups (20-39, 40-59 and 60-80) were isolated. Image-iT™LIVE Green Reactive Oxygen Species (ROS) Kit was used. Reactive Nitrogen Species (RNS) analysis was performed by measuring nitric oxide and peroxynitrite. The PKA, Akt/PKB...
Source: Biogerontology - July 17, 2023 Category: Geriatrics Authors: Filipe Nogueira Franco Luciana de Cassia Cardoso B árbara Néllita Moura Silva Glaucy Rodrigues de Ara újo Miriam Martins Chaves Source Type: research
Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
Biogerontology. 2023 Jul 17. doi: 10.1007/s10522-023-10046-x. Online ahead of print.ABSTRACTOne of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular mechanisms responsible for the resveratrol antioxidant effect on leukocytes from donors aged between 20 and 80 years old. For this, leukocytes from donors of three age groups (20-39, 40-59 and 60-80) were isolated. Image-iT™LIVE Green Reactive Oxygen Species (ROS) Kit was used. Reactive Nitrogen Species (RNS) analysis was performed by measuring nitric oxide and peroxynitrite. The PKA, Akt/PKB...
Source: Biogerontology - July 17, 2023 Category: Geriatrics Authors: Filipe Nogueira Franco Luciana de Cassia Cardoso B árbara Néllita Moura Silva Glaucy Rodrigues de Ara újo Miriam Martins Chaves Source Type: research
