T-cell lymphocytes' aging clock: telomeres, telomerase and aging

Biogerontology. 2023 Nov 2. doi: 10.1007/s10522-023-10075-6. Online ahead of print.ABSTRACTAging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive review of the literature regarding T-cells' telomeres and telomerase in health and age related-diseases.PMID:37917220 | DOI:10.1007/s10522-023-10075-6
Source: Biogerontology - Category: Geriatrics Authors: Source Type: research