Characterization of human placenta-derived exosome (pExo) as a potential osteoarthritis disease modifying therapeutic
Human placenta-derived exosomes (pExo) were generated, characterized, and evaluated as a therapeutic candidate for the treatment of osteoarthritis (OA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 28, 2023 Category: Rheumatology Authors: Chenfei Huang, Yuechao Zhao, Shengchen Lin, Lin Li, Xuan Guo, Sebastian Yumiseba, Jeng-dar Yang, Robert Hariri, Qian Ye, Shuyang He and Adrian Kilcoyne Tags: Research Source Type: research
Impact of IL6R genetic variants on treatment efficacy and toxicity response to sarilumab in rheumatoid arthritis
Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors of response to sarilumab ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 24, 2023 Category: Rheumatology Authors: Luis Sainz, Pau Riera, Patricia Moya, Sara Bernal, Jordi Casademont, Cesar D íaz-Torné, Ana Milena Millán, Hye Sang Park, Adriana Lasa and Hector Corominas Tags: Research Source Type: research
Assessment of axial spondyloarthritis activity using a magnetic resonance imaging-based multi-region-of-interest fusion model
Identifying axial spondyloarthritis (axSpA) activity early and accurately is essential for treating physicians to adjust treatment plans and guide clinical decisions promptly. The current literature is mostly ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 24, 2023 Category: Rheumatology Authors: Peijin Xin, Qizheng Wang, Ruixin Yan, Yongye Chen, Yupeng Zhu, Enlong Zhang, Cui Ren and Ning Lang Tags: Research Source Type: research
Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach
Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have clustered them using machine learning (ML). We applied various ML algorithms to compare the clusters of comorbidi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 22, 2023 Category: Rheumatology Authors: Daniel H. Solomon, Hongshu Guan, Fredrik D. Johansson, Leah Santacroce, Wendi Malley, Lin Guo and Heather Litman Tags: Research Source Type: research
Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis
This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in relation to disea... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 22, 2023 Category: Rheumatology Authors: K Kielbassa, L Van der Weele, AE Voskuyl, N de Vries, E Eldering and TW Kuijpers Tags: Research Source Type: research
Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and scoping review
To determine the prevalence of sustained remission/low disease activity (LDA) in patients with rheumatoid arthritis (RA) after discontinuation of tumor necrosis factor inhibitors (TNFi), separately in inductio... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 20, 2023 Category: Rheumatology Authors: Michael M. Ward, Nima Madanchi, Ali Yazdanyar, Nehal R. Shah and Florina Constantinescu Tags: Research Source Type: research
Risk prediction model for mortality in microscopic polyangiitis: multicentre REVEAL cohort study
To establish refined risk prediction models for mortality in patients with microscopic polyangiitis (MPA) by using comprehensive clinical characteristics. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 20, 2023 Category: Rheumatology Authors: Takuya Kotani, Shogo Matsuda, Ayana Okazaki, Daisuke Nishioka, Ryu Watanabe, Takaho Gon, Atsushi Manabe, Mikihito Shoji, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto and Tohru Takeuchi Tags: Research Source Type: research
TIGIT reverses IFN- α-promoted Th1-like Tregs via in-sequence effects dependent on STAT4
The induction direction of interferon (IFN)- α in T-cell phenotype and function varies depending on the activation state of the cell and the time of stimulation. To assess the effects of elevated IFN-α on regul... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 17, 2023 Category: Rheumatology Authors: Shihan Yu, Jia Gu, Rui Wang, Seunghyun Lee, Yu Shan, Jiakai Wang, Yini Sun and Xiaoxue Ma Tags: Research Source Type: research
Establishment of a differential diagnosis method and an online prediction platform for AOSD and sepsis based on gradient boosting decision trees algorithm
In this study, a machine learning model for differential diagnosis of AOSD and sepsis was developed... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 16, 2023 Category: Rheumatology Authors: Dongmei Zhou, Jingzhi Xie, Jiarui Wang, Juan Zong, Quanquan Fang, Fei Luo, Ting Zhang, Hua Ma, Lina Cao, Hanqiu Yin, Songlou Yin and Shuyan Li Tags: Research Source Type: research
Retraction Note: Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13075-023-03211-7. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 13, 2023 Category: Rheumatology Authors: Nadira Ruzehaji, Jerome Avouac, Muriel Elhai, Maxime Frechet, Camelia Frantz, Barbara Ruiz, Joerg H. Distler and Yannick Allanore Tags: Retraction Note Source Type: research
Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study
Prior research has revealed a heightened prevalence of neoplasms in individuals diagnosed with rheumatoid arthritis (RA). The primary objective of this study is to delve into the causal association between RA ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 13, 2023 Category: Rheumatology Authors: Mingyi Yang, Yani Su, Ke Xu, Jiale Xie, Pengfei Wen, Lin Liu, Zhi Yang and Peng Xu Tags: Research Source Type: research
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/ β-catenin pathway
The aggressive phenotype of fibroblast-like synoviocytes (FLS) has been identified as a contributing factor to the exacerbation of rheumatoid arthritis (RA) through the promotion of synovitis and cartilage dam... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 9, 2023 Category: Rheumatology Authors: Dong Guo, Haoyan Pan, Xueying Lu, Zhong Chen, Laixi Zhou, Shuxin Chen, Jin Huang, Xinzhi Liang, Zhisheng Xiao, Hua Zeng, Yan Shao, Weizhong Qi, Denghui Xie and Chuangxin Lin Tags: Research Source Type: research
Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase
Intradiscal condoliase injection is an alternative therapeutic option for lumbar disc herniation (LDH). However, it is often associated with disc degeneration. Several in vivo studies have demonstrated the reg... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 8, 2023 Category: Rheumatology Authors: Takahiro Hasegawa, Koji Akeda, Junichi Yamada, Koki Kawaguchi, Norihiko Takegami, Tatsuhiko Fujiwara, Takahiro Natsume, Koichiro Ide, Yukihiro Matsuyama and Akihiro Sudo Tags: Research Source Type: research
Bruton ’s tyrosine kinase is a possible therapeutic target in microscopic polyangiitis
Bruton ’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and involved in B-cell receptor- and Fcγ receptor (FcγR)-mediated signal transduction. Btk inhibito... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 6, 2023 Category: Rheumatology Authors: Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru and Akihiro Ishizu Tags: Research Source Type: research
Efficacy and safety of tofacitinib in patients with rheumatoid arthritis by previous treatment: post hoc analysis of phase II/III trials
This study sought to evaluate the efficacy and safety of tofacitinib in patients with rheumatoid arthritis with distinct treatment histories. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 2, 2023 Category: Rheumatology Authors: John Tesser, Ahmet G ül, Ewa Olech, Kurt Oelke, Tatjana Lukic, Kenneth Kwok and Abbas Ebrahim Tags: Research Source Type: research
