Imaging features and clinical value of 18F-FDG PET/CT for predicting airway involvement in patients with relapsing polychondritis
This study ai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 14, 2023 Category: Rheumatology Authors: Jing-Wei Yi, Jun-Feng Huang, Peng Hou, Zi-Kai Lin, Jin-Sheng Lin, Si-Yan Lin, Min Wang, Shi-Yue Li and Xin-Lu Wang Tags: Research Source Type: research
Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes
Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) b... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2023 Category: Rheumatology Authors: Yu-Hsiu Chen, Xin Zhang, David Attarian and Virginia Byers Kraus Tags: Research Source Type: research
Upadacitinib effectiveness and factors associated with minimal disease activity achievement in patients with psoriatic arthritis: preliminary data of a real-life multicenter study
Upadacitinib (UPA) is a selective JAK inhibitor recently approved for the treatment of psoriatic arthritis (PsA). In this post-approval study, we aimed to evaluate the effectiveness and safety of UPA over 24 w... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 11, 2023 Category: Rheumatology Authors: Michele Maria Luchetti Gentiloni, Valentino Paci, Antonio Carletto, Alen Zabotti, Roberta Ramonda, Maria Sole Chimenti, Lorenzo Dagna, Nicoletta Luciano, Anna Piccinelli, Ivan Giovannini, Giovanni Striani, Nicola Boffini, Gilda Sandri, Niccol ò Possemato Tags: Research Source Type: research
Association of anti- β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases
This study aimed to reveal the association bet... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2023 Category: Rheumatology Authors: Katsuhiko Yoneda, Yo Ueda, Kenji Tanimura, Hisashi Arase, Hideto Yamada and Jun Saegusa Tags: Research Source Type: research
Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression
Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 5, 2023 Category: Rheumatology Authors: Lorena Rodriguez-Martinez, Cristina Garc ía-Moreno, Eva Perez-Pampin, María J. Gómara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golán, José A. Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro and Antonio González Tags: Research Source Type: research
The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint pain and swelling, synovial hyperplasia, cartilage damage, and bone destruction. The mechanisms of dendritic cell (DC) and T c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 5, 2023 Category: Rheumatology Authors: Zhandong Wang, Jinlong Zhang, Fangyu An, Jie Zhang, Xiangrui Meng, Shiqing Liu, Ruoliu Xia, Gang Wang and Chunlu Yan Tags: Review Source Type: research
Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB — GRB2/ERK/RUNX2 pathway
Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting on syndesmophyte formation in AS are not we... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 5, 2023 Category: Rheumatology Authors: Yulong Tang, Kai Yang, Qingmei Liu, Yanyun Ma, Hao Zhu, Kunhai Tang, Chengchun Geng, Jiangnan Xie, Dachun Zhuo, Wenyu Wu, Li Jin, Wenze Xiao, Jiucun Wang, Qi Zhu and Jing Liu Tags: Research Source Type: research
Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy
While many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this improvement or worsening. In our unique RA pregnancy cohort that includes a p... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 4, 2023 Category: Rheumatology Authors: Matthew Wright, Mette Kiel Smed, J. Lee Nelson, J ørn Olsen, Merete Lund Hetland, Nicholas P. Jewell, Vibeke Zoffmann and Damini Jawaheer Tags: Research Source Type: research
Low-dose xenogeneic mesenchymal stem cells target canine osteoarthritis through systemic immunomodulation and homing
As current therapies for canine osteoarthritis (OA) provide mainly symptomatic improvement and fail to address the complex pathology of the disease, mesenchymal stem cells (MSCs) offer a promising biological a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 3, 2023 Category: Rheumatology Authors: Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Lore Van Hecke, Koen Chiers, Leen Van Brantegem, Gabriele Braun, Klaus Hellmann, Nathalie de Bouvre, Nathalie Van Bruaene, Tine De Ryck, Luc Duchateau, Bernadette Van Ryssen, Kathelijne Peremans Tags: Research Source Type: research
Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitis
Primary biliary cholangitis (PBC) is an autoimmune liver disease, whose etiology is yet to be fully elucidated. Currently, ursodeoxycholic acid (UDCA) is the only first-line drug. However, 40% of PBC patients ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Siyuan Tian, Yinan Hu, Miao Zhang, Kemei Wang, Guanya Guo, Bo Li, Yulong Shang and Ying Han Tags: Research Source Type: research
Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic synovitis and bone destruction. Proinflammatory cytokines activate pathways of immune-mediated inflammation, which aggravates RA. Th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Fen Zhang, Ting Cheng and Sheng-Xiao Zhang Tags: Review Source Type: research
Hepatorenal pathologies in TNF-transgenic mouse model of rheumatoid arthritis are alleviated by anti-TNF treatment
To examine and quantify liver and kidney lesions and their response to anti-tumor necrosis factor (TNF) therapy in a TNF-Tg mouse model of rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Xuefei Li, Yi Wang, Ziqiang Chen, Ming Ruan, Can Yang, Maolin Zhou, Ning Li, Lianping Xing, Hao Xu, Ling Yang, Qi Shi, Yongjun Wang, Jinman Chen and Qianqian Liang Tags: Research Source Type: research
M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics
N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Yurong Huang, Qiuyun Xue, Jun Chang, Yuting Wang, Chenglong Cheng, Suowen Xu, Xiao Wang and Chenggui Miao Tags: Review Source Type: research
Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 29, 2023 Category: Rheumatology Authors: Youyou Zhang, Xiaoxi Li, Yining Wang, Liru Ge, Faming Pan, Tania Winzenberg and Guoqi Cai Tags: Research Source Type: research
Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start
Rheumatoid arthritis (RA) has a variable impact on different synovial joints, with inflammation being more commonly observed in some joints than others. Emerging evidence suggests that the anatomical variation... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 29, 2023 Category: Rheumatology Authors: Adrian Ciurea, Oliver Distler, Kenneth Kwok, Hyejin Jo, Lisy Wang, Tim Killeen, Caroline Ospelt and Mojca Frank Bertoncelj Tags: Research Source Type: research
