Iguratimod suppresses Tfh cell differentiation in primary Sj ögren’s syndrome patients through inhibiting Akt/mTOR/STAT3 signaling
This study aimed ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 22, 2023 Category: Rheumatology Authors: Taibiao Lyu, Hui Jiang, Liuting Zeng, Suying Liu, Chengmei He, Chaowen Luo, Lin Qiao, Yan Zhao and Hua Chen Tags: Research Source Type: research
Efficacy of tofacitinib on enthesitis in patients with active psoriatic arthritis: analysis of pooled data from two phase 3 studies
Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post hoc analysis assessed tofacitinib efficacy on enthesitis by baseline location and severity, and impact on... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 22, 2023 Category: Rheumatology Authors: Philip J. Mease, Ana-Maria Orbai, Oliver FitzGerald, Mohamed Bedaiwi, Dona L. Fleishaker, Rajiv Mundayat, Pamela Young and Philip S. Helliwell Tags: Research Source Type: research
Iguratimod attenuated fibrosis in systemic sclerosis via targeting early growth response 1 expression
The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Iguratimod is a synthesized anti-rheumatic disease-modifying drug, which shows drastic in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 18, 2023 Category: Rheumatology Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan Tags: Research Source Type: research
A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA
While it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kidney disease, the specific role of klotho in rheumatoid arthritis (RA) and its effect on... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 16, 2023 Category: Rheumatology Authors: Qin-cheng Che, Qian Jia, Xiao-yu Zhang, Shu-ning Sun, Xiao-jie Zhang and Qiang Shu Tags: Research Source Type: research
Effect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study
Guselkumab is a selective interleukin (IL)-23 inhibitor targeting the IL-23p19 subunit. In the phase 3b COSMOS trial, guselkumab demonstrated efficacy in treating participants with active psoriatic arthritis (... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 16, 2023 Category: Rheumatology Authors: Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates and Stefan Siebert Tags: Research Source Type: research
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
In addition to decreasing the level of cholesterol, proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the impact of PCSK9 on autoimmune dis... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 14, 2023 Category: Rheumatology Authors: Weijia Xie, Jiaxin Li, Hao Du and Jian Xia Tags: Research Source Type: research
Effect of intra-knee injection of autologous adipose stem cells or mesenchymal vascular components on short-term outcomes in patients with knee osteoarthritis: an updated meta-analysis of randomized controlled trials
Assess the efficacy of single and multiple intra-articular injections of autologous adipose-derived stem cells (ASCs) and adipose-derived stromal vascular fraction (ADSVF) for the treatment of knee osteoarthri... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 10, 2023 Category: Rheumatology Authors: Yang Yang, Zhibin Lan, Jiangbo Yan, Zhiqun Tang, Linghui Zhou, Dian Jin and Qunhua Jin Tags: Review Source Type: research
SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF- β pathway in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 9, 2023 Category: Rheumatology Authors: Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun and Youhua Wang Tags: Research Source Type: research
Psoriasis seems often underdiagnosed in patient with axial spondyloarthritis
Axial spondyloarthritis (axSpA) is known to be associated with several extra-skeletal manifestations (ESM), including the inflammatory skin disease psoriasis. It is important to recognize and diagnose psoriasi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 9, 2023 Category: Rheumatology Authors: Angelique Rondags, Laura van Marle, Barbara Horv áth, Freke R. Wink, Suzanne Arends and Anneke Spoorenberg Tags: Research Source Type: research
Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice
This study is to investigate th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 9, 2023 Category: Rheumatology Authors: Meng Chen, Wenyu Fu, Huiyun Xu and Chuan-ju Liu Tags: Research Source Type: research
Association between periodontitis and temporomandibular joint disorders
Periodontitis (PD) may affect temporomandibular joint disorders (TMD) and TMD may influence PD in previous observational studies. Nevertheless, these studies were prone to confounders and reverse causation, le... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 8, 2023 Category: Rheumatology Authors: Shaotai Wang, Huan Jiang, Huichuan Qi, Danfeng Luo, Tianyuan Qiu and Min Hu Tags: Research Source Type: research
Patients with radiographic axial spondylarthritis have an impaired dietary intake —a cross-sectional study with matched controls from northern Sweden
Radiographic axial spondyloarthritis (r-axSpA) is one of the most common chronic inflammatory rheumatic diseases, affecting about 0.2% of the Swedish population. Adequate nutritional intake is essential for ma... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 7, 2023 Category: Rheumatology Authors: Erik Hulander, Tatiana Zverkova Sandstr öm, Jeannette Beckman Rehnman, Lucy Law, Stefan Söderberg and Helena Forsblad-d’Elia Tags: Research Source Type: research
Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis
Disruption of glucocorticoid (GC) signaling in osteoblasts results in a marked attenuation of acute antibody-induced arthritis. The role of endogenous GCs in chronic inflammatory arthritis is however not fully... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 4, 2023 Category: Rheumatology Authors: Tazio Maleitzke, Edgar Wiebe, D örte Huscher, Cornelia M. Spies, Jinwen Tu, Timo Gaber, Yu Zheng, Frank Buttgereit, Markus J. Seibel and Hong Zhou Tags: Research Source Type: research
Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population
The HFA-PEFF score has been validated to hold great diagnostic and prognostic utility for heart failure with preserved ejection fraction (HFpEF). Idiopathic inflammatory myopathy (IIM) is recognized as one of ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 4, 2023 Category: Rheumatology Authors: Yunjing Shi, Hao Zhang, Zeping Qiu, Yanjia Chen, Xiuxiu Su, Huihui Chi, Tienan Feng, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Qiongyi Hu, Zhuochao Zhou, Jianfen Meng, Jialin Teng & hellip; Tags: Research Source Type: research
Role of inflammatory burden and treatment on joint space width in psoriatic arthritis —a high-resolution peripheral quantitative computed tomography study
To investigate the relationship between disease-related parameters and joint space width (JSW) on high-resolution peripheral quantitative computed tomography (HR-pQCT) in psoriatic arthritis (PsA) patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 3, 2023 Category: Rheumatology Authors: Yingzhao Jin, Isaac T Cheng, Ho So, Dongze Wu, James F Griffith, Vivian W Hung, Ling Qin, Cheuk-Chun Szeto, Agnes WS Chan and Lai-Shan Tam Tags: Research Source Type: research
