Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathway inhibition
Stringent remission criteria are crucial in rheumatoid arthritis (RA) assessment. Disease activity score in 28 joints (DAS28)-remission has not been included among American College of Rheumatology/European Lea... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 4, 2017 Category: Rheumatology Authors: M. Schoels, F. Alasti, J. S. Smolen and D. Aletaha Source Type: research

Cardiovascular disease risk profiles in inflammatory joint disease entities
Patients with inflammatory joint diseases (IJD) have increased risk of cardiovascular disease (CVD). Our aim was to compare CVD risk profiles in patients with IJD, including rheumatoid arthritis (RA), axial sp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 3, 2017 Category: Rheumatology Authors: Grunde Wibetoe, Eirik Ikdahl, Silvia Rollefstad, Inge C. Olsen, Kjetil Bergsmark, Tore K. Kvien, Anne Salberg, Dag Magnar Soldal, Gunnstein Bakland, Åse Lexberg, Bjørg-Tilde Fevang, Hans Christian Gulseth, Glenn Haugeberg and Anne Grete Semb Source Type: research

Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro
Histone deacetylase (HDAC) inhibitor has recently been reported to have a therapeutic effect as an anti-inflammatory agent in collagen-induced arthritis (CIA). We investigated the therapeutic effect of a new s... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 3, 2017 Category: Rheumatology Authors: Bo Ram Oh, Dong-hyeon Suh, Daekwon Bae, Nina Ha, Young Il Choi, Hyun Jung Yoo, Jin Kyun Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song Source Type: research

Anti-citrullinated protein antibodies and bone loss in patients with early arthritis: comment on the article “Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis” by Bugatti et al.
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 3, 2017 Category: Rheumatology Authors: Santos Casta ñeda, Irene Llorente, Rosario García-Vicuña and Isidoro González-Álvaro Source Type: research

Fluorescence optical imaging and musculoskeletal ultrasonography in juvenile idiopathic polyarticular disease before and during antirheumatic treatment  - a multicenter non-interventional diagnostic evaluation
Valid detection of inflamed joints is essential for correct classification, therapeutic decisions, prognosis and assessment of treatment efficacy in juvenile idiopathic arthritis (JIA). Fluorescence optical im... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 30, 2017 Category: Rheumatology Authors: Ariane Klein, Georg Werner Just, Stephanie Gabriele Werner, Prasad T. Oommen, Kirsten Minden, Ingrid Becker, Hans-Eckhard Langer, Dirk Klee and Gerd Horneff Source Type: research

Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles
Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do n... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 30, 2017 Category: Rheumatology Authors: Charlotte H. Hulme, Emma L. Wilson, Mandy J. Peffers, Sally Roberts, Deborah M. Simpson, James B. Richardson, Pete Gallacher and Karina T. Wright Source Type: research

Animal models of rheumatoid pain: experimental systems and insights
Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflam... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 30, 2017 Category: Rheumatology Authors: Bradford D. Fischer, Adeshina Adeyemo, Michael E. O ’Leary and Andrea Bottaro Source Type: research

Cardiovascular risk factors predate the onset of symptoms of rheumatoid arthritis: a nested case –control study
Patients with rheumatoid arthritis (RA) are at increased risk of developing cardiovascular disease (CVD). Our aim was to evaluate the impact of factors related to CVD, such as smoking, lipid levels, hypertensi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 30, 2017 Category: Rheumatology Authors: Heidi Kokkonen, Hans Stenlund and Solbritt Rantap ää-Dahlqvist Source Type: research

Rheumatology in the Middle East in 2017: clinical challenges and research
The World Health Organization (WHO) has ranked musculoskeletal diseases among the top ten leading causes of disability in the Middle East. The situation in the Middle East is unique as, although seventeen coun... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 30, 2017 Category: Rheumatology Authors: Abdulla Watad, Jamal Al-Saleh, Merav Lidar, Howard Amital and Yehuda Shoenfeld Source Type: research

Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS study
Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 20, 2017 Category: Rheumatology Authors: Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello and Lorenzo Beretta Source Type: research

Work outcome in yet undiagnosed patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis; results of a cross-sectional study among patients with chronic low back pain
To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 17, 2017 Category: Rheumatology Authors: Lonneke van Hoeven, Annelies E. R. C. H. Boonen, Johanna M. W. Hazes and Angelique E. A. M. Weel Source Type: research

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis
Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary f... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 17, 2017 Category: Rheumatology Authors: Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Carol A. Feghali-Bostwick and Peter D. Katsikis Source Type: research

Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells
The peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine and chemokine milieu. We aimed... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2017 Category: Rheumatology Authors: Alan Sucur, Zrinka Jajic, Marinko Artukovic, Marina Ikic Matijasevic, Branimir Anic, Darja Flegar, Antonio Markotic, Tomislav Kelava, Sanja Ivcevic, Natasa Kovacic, Vedran Katavic and Danka Grcevic Source Type: research

Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis
To analyze differences in the recognition of anti-citrullinated peptide/protein antibody (ACPA) citrullinated epitopes and isotypes in patients with palindromic rheumatism (PR) and rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2017 Category: Rheumatology Authors: Sonia Cabrera-Villalba, Mar ía José Gomara, Juan D. Cañete, Julio Ramírez, Georgina Salvador, Virginia Ruiz-Esquide, Maria Victoria Hernández, José Inciarte-Mundo, Isabel Haro and Raimon Sanmartí Source Type: research

Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial
Previous research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2017 Category: Rheumatology Authors: Agnes Hartl, Joachim Sieper, Uta Syrbe, Joachim Listing, Kay-Geert Hermann, Martin Rudwaleit and Denis Poddubnyy Source Type: research

Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a geneti... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2017 Category: Rheumatology Authors: Adri à Aterido, Antonio Julià, Patricia Carreira, Ricardo Blanco, José Javier López-Longo, José Javier Pérez Venegas, Àlex Olivé, José Luís Andreu, Maria Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco-de la Fuente, An Source Type: research

IFN- λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE)
In this study, we measured levels of IFN-α, IFN-λ1,... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2017 Category: Rheumatology Authors: Vilija Oke, Susanna Brauner, Anders Larsson, Johanna Gustafsson, Agneta Zickert, Iva Gunnarsson and Elisabet Svenungsson Source Type: research

High sensitivity and negative predictive value of the  DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center
Pulmonary arterial hypertension (PAH) is one of the most relevant causes of death in systemic sclerosis. The aims of this study were to analyse the recently published DETECT algorithm comparing it with Europea... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2017 Category: Rheumatology Authors: Alfredo Guill én-Del Castillo, Eduardo L. Callejas-Moraga, Gabriela García, José F. Rodríguez-Palomares, Antonio Román, Cristina Berastegui, Manuel López-Meseguer, Enric Domingo, Vicente Fonollosa-Plá and Carmen Pilar Simeón-Aznar Source Type: research

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients
Persistent expansion of circulating CD4+ effector memory T cells (TEM) in patients with granulomatosis with polyangiitis (GPA) suggests their fundamental role in disease pathogenesis. Recent studies have shown th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2017 Category: Rheumatology Authors: Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa and Wayel H. Abdulahad Source Type: research

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF- β-Smad2 signaling in naïve helper T cells
Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transformi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2017 Category: Rheumatology Authors: Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada and Tetsuji Naka Source Type: research

The effects of resistance training on muscle strength, joint pain, and hand function in individuals with hand osteoarthritis: a systematic review and meta-analysis
Hand osteoarthritis is a common condition characterised by joint pain and muscle weakness. These factors are thought to contribute to ongoing disability. Some evidence exists that resistance training decreases... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2017 Category: Rheumatology Authors: Nicol ó Edoardo Magni, Peter John McNair and David Andrew Rice Source Type: research

The cumulative number of micro-haemorrhages and micro-thromboses in nailfold videocapillaroscopy is a good indicator of disease activity in systemic sclerosis: a validation study of the NEMO score
Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), su... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2017 Category: Rheumatology Authors: Romina Andracco, Rosaria Irace, Eleonora Zaccara, Serena Vettori, Wanda Maglione, Antonella Riccardi, Francesca Pignataro, Roberta Ferrara, Domenico Sambataro, Gianluca Sambataro, Claudio Vitali, Gabriele Valentini and Nicoletta Del Papa Source Type: research

Drug safety analyses in a rheumatoid arthritis registry: application of different approaches regarding timing of exposure and confounder measurement
Patient registry data serves an increasing role in drug safety and comparative effectiveness research, but registry databases often do not contain confounder information measured at the same time that treatmen... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2017 Category: Rheumatology Authors: Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Agnes Zak, Michelle Frits and Jessica M. Franklin Source Type: research

High-sensitivity cardiac troponin T is a biomarker for atherosclerosis in systemic lupus erythematous patients: a cross-sectional controlled study
Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whet... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2017 Category: Rheumatology Authors: Gillian Divard, Rachid Abbas, Camille Chenevier-Gobeaux, No émie Chanson, Brigitte Escoubet, Marie-Paule Chauveheid, Antoine Dossier, Thomas Papo, Monique Dehoux and Karim Sacre Source Type: research

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis
Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the ther... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2017 Category: Rheumatology Authors: Katsunari Makino, Tomoko Makino, Lukasz Stawski, Kenneth E. Lipson, Andrew Leask and Maria Trojanowska Source Type: research

Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse
Relapse of disease is frequent in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). It is unclear whether persistent ANCA when starting maintenance therapy increases the risk of relapse. W... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2017 Category: Rheumatology Authors: Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F. Hiemstra, Oliver Flossmann, Annelies Berden, Peter H öglund and Lorraine Harper Source Type: research

MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation
Studies have shown that structural lesions may be present in patients with non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of structural lesions in these patients is unclear, partic... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2017 Category: Rheumatology Authors: Walter P. Maksymowych, Stephanie Wichuk, Maxime Dougados, Heather Jones, Annette Szumski, Jack F. Bukowski, Lisa Marshall and Robert G. Lambert Source Type: research

Pulmonary arterial hypertension in scleroderma: care gaps in screening
One in six patients with systemic sclerosis will develop pulmonary arterial hypertension (PAH). Screening with echocardiography and possibly pulmonary function testing (to determine the diffusing capacity of c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2017 Category: Rheumatology Authors: Janet E. Pope Source Type: research

Gout and subsequent erectile dysfunction: a population-based cohort study from England
An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2017 Category: Rheumatology Authors: Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston and Edward Roddy Source Type: research

Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders —findings of a multicenter population-based study
We determined the prevalence of anti-nuclear autoantibodies (ANAs) in the German adult population and examined the association between ANAs and cardiovascular and metabolic disorders. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2017 Category: Rheumatology Authors: Manas K. Akmatov, Nadja R öber, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Halina Greiser, Kathrin Günther, Rudolf Kaaks, Yvonne Kemmling, Bastian Krone, Jakob Linseisen, Christa Meisinger, Susanne Moebus, Nadia Obi, Carlos A. Guzman, Karsten C Source Type: research

RANK/RANKL/OPG system in the intervertebral disc
The receptor activator of NF- κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2017 Category: Rheumatology Authors: Norihiko Takegami, Koji Akeda, Junichi Yamada, Tomohiko Sano, Koichiro Murata, Jenny Huang, Koichi Masuda and Akihiro Sudo Source Type: research

Survival and quality of life in incident systemic sclerosis-related pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a leading cause of mortality in systemic sclerosis (SSc). We sought to determine survival, predictors of mortality, and health-related quality of life (HRQoL) related t... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2017 Category: Rheumatology Authors: Kathleen Morrisroe, Wendy Stevens, Molla Huq, David Prior, Jo Sahhar, Gene-Siew Ngian, David Celermajer, Jane Zochling, Susanna Proudman and Mandana Nikpour Source Type: research

Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome
This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2017 Category: Rheumatology Authors: Jing Wang, Yubing Wen, Mengyu Zhou, Xiaoxiao Shi, Lanping Jiang, Mingxi Li, Yang Yu, Xuemei Li, Xuewang Li, Wen Zhang, Andrew L. Lundquist and Limeng Chen Source Type: research

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical
Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflictin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2017 Category: Rheumatology Authors: Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Bj örn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist and Annette H. M. van der Helm-van Mil Source Type: research

Exosomal amyloid A and lymphatic vessel endothelial hyaluronic acid receptor-1 proteins are associated with disease activity in rheumatoid arthritis
Exosomes are thought to play an important role in exchanging information between cells. The proteins and lipids in exosomes play roles in mediating inflammatory and autoimmune diseases. The aim of this study w... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2017 Category: Rheumatology Authors: Jihyung Yoo, Sang Kwang Lee, Mikyung Lim, Donghyuk Sheen, Eun-Hye Choi and Soon Ae Kim Source Type: research

Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts
The Assessment of SpondyloArthritis international Society (ASAS) definition of a positive family history (PFH) of spondyloarthritis (SpA) includes the following diseases in first- or second-degree relatives: a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2017 Category: Rheumatology Authors: Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landew é, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde and Floris van Gaalen Source Type: research

Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis
Microscopic polyangiitis (MPA), which is classified as an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis, is one of the most frequent primary vasculitides in Japan. We earlier n... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2017 Category: Rheumatology Authors: Akihiro Ishizu, Utano Tomaru, Sakiko Masuda, Ken-ei Sada, Koichi Amano, Masayoshi Harigai, Yasushi Kawaguchi, Yoshihiro Arimura, Kunihiro Yamagata, Shoichi Ozaki, Hiroaki Dobashi, Sakae Homma, Yasunori Okada, Hitoshi Sugiyama, Joichi Usui, Naotake Tsuboi Source Type: research

Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis
Obesity is associated with worse disease activity and drug responses in patients with rheumatoid arthritis (RA). However, the immunological mechanisms responsible for the relationship between RA and obesity ha... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2017 Category: Rheumatology Authors: Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Keiichi Sakurai, Shuji Sumitomo, Keishi Fujio and Kazuhiko Yamamoto Source Type: research

Tie2 as a novel key factor of microangiopathy in systemic sclerosis
The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 25, 2017 Category: Rheumatology Authors: Falk Moritz, Janine Schniering, J örg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler and Britta Maurer Source Type: research

Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis
In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAIS... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 25, 2017 Category: Rheumatology Authors: C. Derambure, G. Dzangue-Tchoupou, C. Berard, N. Vergne, M. Hiron, M. A. D ’Agostino, P. Musette, O. Vittecoq and T. Lequerré Source Type: research

Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice
The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 25, 2017 Category: Rheumatology Authors: Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid and Eugene Krustev Source Type: research

Pregnancy-induced gene expression changes in vivo among women with rheumatoid arthritis: a pilot study
Little is known about gene expression changes induced by pregnancy in women with rheumatoid arthritis (RA) and healthy women because the few studies previously conducted did not have pre-pregnancy samples avai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 25, 2017 Category: Rheumatology Authors: Dana E. Goin, Mette Kiel Smed, Lior Pachter, Elizabeth Purdom, J. Lee Nelson, Hanne Kj ærgaard, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Bent Ottesen and Damini Jawaheer Source Type: research

Ultrasound-detected bone erosion is a relapse risk factor after discontinuation of biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis whose ultrasound power Doppler synovitis activity and clinical disease activity are well controlled
In the present study, we explored the risk factors for relapse after discontinuation of biologic disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) whose ultrasoun... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 25, 2017 Category: Rheumatology Authors: Shin-ya Kawashiri, Keita Fujikawa, Ayako Nishino, Akitomo Okada, Toshiyuki Aramaki, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Akinari Mizokami, Hideki Nakamura, Tomoki O Source Type: research

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis
The aim was to investigate CD4+T-cell subsets, immune cells and their cytokine profiles in blood and synovial compartments in rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA) to define specific immu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 19, 2017 Category: Rheumatology Authors: Alessandra Penatti, Federica Facciotti, Roberta De Matteis, Paola Larghi, Moira Paroni, Antonella Murgo, Orazio De Lucia, Massimiliano Pagani, Luca Pierannunzii, Marcello Truzzi, Andreea Ioan-Facsinay, Sergio Abrignani, Jens Geginat and Pier Luigi Meroni Source Type: research

Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study
To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyl... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 18, 2017 Category: Rheumatology Authors: Karin Bengtsson, Helena Forsblad-d ’Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling and Lennart T. H. Jacobsson Source Type: research

M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis
Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 18, 2017 Category: Rheumatology Authors: Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G. M. Kallenberg and Johanna Westra Source Type: research

TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study
Magnetic resonance imaging (MRI) and computed tomography (CT) angiography have now largely replaced interventional angiography in the diagnoses and follow up of Takayasu arteritis (TAK) but data on the effects... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 18, 2017 Category: Rheumatology Authors: Birgir Gudbrandsson, Øyvind Molberg and Øyvind Palm Source Type: research

B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients
B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been shown to be effective in AAV maintenance therapy, but... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 18, 2017 Category: Rheumatology Authors: Jens Thiel, Marta Rizzi, Marie Engesser, Ann-Kathrin Dufner, Arianna Troilo, Raquel Lorenzetti, Reinhard E. Voll and Nils Venhoff Source Type: research

Development of a clinical prediction algorithm for knee osteoarthritis structural progression in a cohort study: value of adding measurement of subchondral bone density
Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 16, 2017 Category: Rheumatology Authors: Michael P. LaValley, Grace H. Lo, Lori Lyn Price, Jeffrey B. Driban, Charles B. Eaton and Timothy E. McAlindon Source Type: research

Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis
Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aim... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 16, 2017 Category: Rheumatology Authors: Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto and Keishi Fujio Source Type: research