Vascular endothelial growth factor levels and rheumatic diseases of the elderly
Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PM... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 1, 2016 Category: Rheumatology Authors: Perrine Smets, Val érie Devauchelle-Pensec, Paul-Olivier Rouzaire, Bruno Pereira, Marc Andre and Martin Soubrier Source Type: research

Abdominal obesity, gender and the risk of rheumatoid arthritis – a nested case–control study
The risk of development of rheumatoid arthritis (RA) could be affected by immune activation in obesity. Our objective was to evaluate the association between obesity in general, and abdominal obesity, and the ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 29, 2016 Category: Rheumatology Authors: Lotta Ljung and Solbritt Rantap ää-Dahlqvist Source Type: research

Intestinal dysbiosis is common in systemic sclerosis and associated with gastrointestinal and extraintestinal features of disease
The objective of this study was to investigate th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 29, 2016 Category: Rheumatology Authors: Kristofer Andr éasson, Zaid Alrawi, Anita Persson, Göran Jönsson and Jan Marsal Source Type: research

Clinical improvement and reduction in serum calprotectin levels after an intensive exercise programme for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis
The efficacy of exercise therapy for ankylosing spondylitis (AS) is well-documented, but dearth of information is for non-radiographic axial spondyloarthritis (nr-axSpA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 25, 2016 Category: Rheumatology Authors: Andrea Levitova, Hana Hulejova, Maja Spiritovic, Karel Pavelka, Ladislav Senolt and Marketa Husakova Source Type: research

Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study
This study aimed to clarify the factors re... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 25, 2016 Category: Rheumatology Authors: Ichiro Mizushima, Motohisa Yamamoto, Dai Inoue, Shinichi Nishi, Yoshinori Taniguchi, Yoshifumi Ubara, Shoko Matsui, Tetsuhiko Yasuno, Hitoshi Nakashima, Hiroki Takahashi, Kazunori Yamada, Hideki Nomura, Masakazu Yamagishi, Takao Saito and Mitsuhiro Kawano Source Type: research

Fab glycosylation of immunoglobulin G does not associate with improvement of rheumatoid arthritis during pregnancy
Changes in immunoglobulin G (IgG) constant domain (Fc) glycosylation are associated with changes in rheumatoid arthritis (RA) disease activity in response to pregnancy. Here, we sought to determine whether the... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 25, 2016 Category: Rheumatology Authors: Albert Bondt, Manfred Wuhrer, T. Martijn Kuijper, Johanna M. W. Hazes and Radboud J. E. M. Dolhain Source Type: research

p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis
Dominant-negative somatic mutations of p53 has been identified in the synovium of patients with rheumatoid arthritis (RA), in which interleukin (IL)-6 has been established as a pivotal inflammatory cytokine. T... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 24, 2016 Category: Rheumatology Authors: Ting Zhang, Huihua Li, Juan Shi, Sha Li, Muyuan Li, Lei Zhang, Leting Zheng, Dexian Zheng, Fulin Tang, Xuan Zhang, Fengchun Zhang and Xin You Source Type: research

Comparison of treatment response, remission rate and drug adherence in polyarticular juvenile idiopathic arthritis patients treated with etanercept, adalimumab or tocilizumab
Treatment response, remission rates and compliance in patients with polyarticular juvenile idiopathic arthritis (polyJIA) treated with adalimumab, etanercept, or tocilizumab were analyzed in clinical practice. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 24, 2016 Category: Rheumatology Authors: Gerd Horneff, Ariane Klein, Jens Klotsche, Kirsten Minden, Hans-Iko Huppertz, Frank Weller-Heinemann, Jasmin Kuemmerle-Deschner, Johannes-Peter Haas and Anton Hospach Source Type: research

Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis
The complement system has been implicated in pathogenesis of systemic sclerosis (SSc). The goal of the present study was to evaluate improved complement biomarkers in SSc. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 18, 2016 Category: Rheumatology Authors: Marcin Okr ój, Martin Johansson, Tore Saxne, Anna M. Blom and Roger Hesselstrand Source Type: research

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
We investigated two distinct synovial fibroblast populations that were located preferentially in the lining or sub-lining layers and defined by their expression of either podoplanin (PDPN) or CD248, and explor... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 18, 2016 Category: Rheumatology Authors: Adam P. Croft, Amy J. Naylor, Jennifer L. Marshall, Debbie L. Hardie, Birgit Zimmermann, Jason Turner, Guillaume Desanti, Holly Adams, Adrian I. Yemm, Ulf M üller-Ladner, Jean-Michel Dayer, Elena Neumann, Andrew Filer and Christopher D. Buckley Source Type: research

Profibrotic mediators in tendon disease: a systematic review
Tendon disease is characterized by the development of fibrosis. Transforming growth factor beta (TGF- β), bone morphogenic proteins (BMPs) and connective tissue growth factor (CTGF) are key mediators in the pat... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 18, 2016 Category: Rheumatology Authors: Wataru Morita, Sarah Jane Bothwell Snelling, Stephanie Georgina Dakin and Andrew Jonathan Carr Source Type: research

Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout
Interleukin (IL)-37 has emerged as a fundamental inhibitor of innate immunity. Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals. In the current study, we assessed the prev... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 18, 2016 Category: Rheumatology Authors: Lei Liu, Yu Xue, Yingfeng Zhu, Dandan Xuan, Xue Yang, Minrui Liang, Juan Wang, Xiaoxia Zhu, Jiong Zhang and Hejian Zou Source Type: research

B-cell imaging with zirconium-89 labelled rituximab PET-CT at baseline is associated with therapeutic response 24  weeks after initiation of rituximab treatment in rheumatoid arthritis patients
B cells are key players in the pathogenesis of rheumatoid arthritis (RA). Although successful in 50 –60% of patients with RA, anti-B-cell therapy given as rituximab could be more efficient by identifying potent... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 18, 2016 Category: Rheumatology Authors: Stefan Bruijnen, Michel Tsang-A-Sjoe, Hennie Raterman, Tamara Ramwadhdoebe, Dani ëlle Vugts, Guus van Dongen, Marc Huisman, Otto Hoekstra, Paul-Peter Tak, Alexandre Voskuyl and Conny van der Laken Source Type: research

Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE
Recent studies have shown that alterations in the function of dendritic cells (DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of the alteration remains uncl... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 16, 2016 Category: Rheumatology Authors: Yilun Wang, Jun Liang, Haihong Qin, Yan Ge, Juan Du, Jinran Lin, Xiaohua Zhu, Jie Wang and Jinhua Xu Source Type: research

Work productivity is associated with disease activity and functional ability in Italian patients with early axial spondyloarthritis: an observational study from the SPACE cohort
Spondyloarthritis often affects young people, typically in their working years. The aim of our study was to investigate work productivity and its relationship with disease activity and physical functioning in ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 16, 2016 Category: Rheumatology Authors: Manouk de Hooge, Roberta Ramonda, Mariagrazia Lorenzin, Paola Frallonardo, Leonardo Punzi, Augusta Ortolan and Andrea Doria Source Type: research

Circulating exosomes from patients with systemic lupus erythematosus induce an proinflammatory immune response
Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute to the inflammatory response in systemic lupus erythematosus (... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 16, 2016 Category: Rheumatology Authors: Joo Youn Lee, Jin Kyun Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song Source Type: research

Transplantation of gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis
Rheumatoid arthritis (RA) is a chronic, progressive, and inflammatory autoimmune disease which primarily affects the small arthrodial joints. The aim of this study was to test whether transplantation of mesenc... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 11, 2016 Category: Rheumatology Authors: Yongchun Gu and Songtao Shi Source Type: research

Effects of anti-TNF- α treatment on lipid profile in rheumatic diseases: an analytical cohort study
The aim was to assess the influence of long-term treatment with tumor necrosis factor alpha (TNF- α) inhibitors on total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipopro... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 10, 2016 Category: Rheumatology Authors: Shadi Hassan, Uzi Milman, Joy Feld, Lihi Eder, Idit Lavi, Shai Cohen and Devy Zisman Source Type: research

Comparative effectiveness of treatment with the first TNF antagonist in monotherapy, the first TNF antagonist plus one conventional synthetic disease-modifying antirheumatic drug, and the first TNF antagonist plus two or more conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
Rheumatoid arthritis (RA) patients are treated with a mean of 3 –4 conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) with or without glucocorticoids (GCs), before the first biologic prescr... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 8, 2016 Category: Rheumatology Authors: Blanca Hern ández-Cruz, Esther Márquez-Saavedra, Rafael Caliz-Caliz and Federico Navarro-Sarabia Source Type: research

Glucocorticoids and endothelial function in inflammatory diseases: focus on rheumatoid arthritis
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease characterized by articular and extra-articular manifestations involving cardiovascular (CV) diseases. RA increases the CV mortality by u... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 5, 2016 Category: Rheumatology Authors: Frank Verhoeven, Cl ément Prati, Katy Maguin-Gaté, Daniel Wendling and Céline Demougeot Source Type: research

Erratum to: Concentration of antibodies against Porphyromonas gingivalisis increased before the onset of symptoms of rheumatoid arthritis
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 4, 2016 Category: Rheumatology Authors: Linda Johansson, Natalia Sherina, Nastya Kharlamova, Barbara Potempa, Barbro Larsson, Lena Israelsson, Jan Potempa, Solbritt Rantap ää-Dahlqvist and Karin Lundberg Source Type: research

Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study
In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure-modifying effect, to date CS use is still under debate. A clinical stu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 3, 2016 Category: Rheumatology Authors: Jean-Pierre Pelletier, Jean-Pierre Raynauld, Andr é D. Beaulieu, Louis Bessette, Frédéric Morin, Artur J. de Brum-Fernandes, Philippe Delorme, Marc Dorais, Patrice Paiement, François Abram and Johanne Martel-Pelletier Source Type: research

Functional electrical stimulation of gluteus medius reduces the medial joint reaction force of the knee during level walking
By altering muscular activation patterns, internal forces acting on the human body during dynamic activity may be manipulated. The magnitude of one of these forces, the medial knee joint reaction force (JRF), ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 3, 2016 Category: Rheumatology Authors: Lance Rane and Anthony Michael James Bull Source Type: research

The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules
Presentation of citrullinated neo-epitopes by HLA-DRB1 molecules that carry the shared epitope (SE) sequence was proposed to explain the association between HLA and seropositive RA. Although it is shown that s... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 3, 2016 Category: Rheumatology Authors: Arieke S. B. Kampstra, Jurgen van Heemst, Antonis K. Moustakas, George K. Papadopoulos, Tom W. J. Huizinga and Ren é E. M. Toes Source Type: research

Patient global assessment in measuring disease activity in rheumatoid arthritis: a review of the literature
Patient-reported outcomes (PROs) reflect the patient ’s perspective and are used in rheumatoid arthritis (RA) routine clinical practice. Patient global assessment (PGA) is one of the most widely used PROs in RA... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 28, 2016 Category: Rheumatology Authors: Elena Nikiphorou, Helga Radner, Katerina Chatzidionysiou, Carole Desthieux, Codruta Zabalan, Yvonne van Eijk-Hustings, William G. Dixon, Kimme L. Hyrich, Johan Askling and Laure Gossec Source Type: research

Evaluation of a patient decision aid for initiating disease modifying anti-rheumatic drugs
According to international guidelines, treatment of inflammatory arthritis should be based on a shared decision between patient and rheumatologist. Furthermore, patients with inflammatory arthritis have high n... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 28, 2016 Category: Rheumatology Authors: Ingrid Nota, Constance H. C. Drossaert, Erik Taal, Harald E. Vonkeman, Cees J. Haagsma and Mart A. F. J. van de Laar Source Type: research

Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment
Significant peripheral blood CD4+ T-cell depletion has been observed after a first cycle of rituximab, a monoclonal antibody directed against the CD20 antigen, which is currently used in rheumatoid arthritis. ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 28, 2016 Category: Rheumatology Authors: Matthieu Lavielle, Denis Mulleman, Philippe Goupille, Cl ément Bahuaud, Hsueh Cheng Sung, Hervé Watier and Gilles Thibault Source Type: research

Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease
There is currently no blood-based test for detection of early-stage osteoarthritis (OA) and the anti-cyclic citrullinated peptide (CCP) antibody test for rheumatoid arthritis (RA) has relatively low sensitivit... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 27, 2016 Category: Rheumatology Authors: Usman Ahmed, Attia Anwar, Richard S. Savage, Paul J. Thornalley and Naila Rabbani Source Type: research

Bone loss and aggravated autoimmune arthritis in HLA-DR β1-bearing humanized mice following oral challenge with Porphyromonas gingivalis
The linkage between periodontal disease and rheumatoid arthritis is well established. Commonalities among the two are that both are chronic inflammatory diseases characterized by bone loss, an association with... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 26, 2016 Category: Rheumatology Authors: Indra Sandal, Anastasios Karydis, Jiwen Luo, Amanda Prislovsky, Karen B. Whittington, Edward F. Rosloniec, Chen Dong, Deborah V. Novack, Piotr Mydel, Song Guo Zheng, Marko Z. Radic and David D. Brand Source Type: research

Psoriatic arthritis is associated with bone loss of the metacarpals
BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 25, 2016 Category: Rheumatology Authors: Alexander Pfeil, Laura Krojniak, Diane M. Renz, Lisa Reinhardt, Marcus Franz, Peter Oelzner, Gunter Wolf and Joachim B öttcher Source Type: research

Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans
Evidence suggests that the presence of peptidyl arginine deiminase type 4 (PAD4) antibodies is associated with radiographic-severity rheumatoid arthritis (RA) among Caucasian patients. The presence of anti-PAD... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 22, 2016 Category: Rheumatology Authors: Iris Navarro-Mill án, Erika Darrah, Andrew O. Westfall, Ted R. Mikuls, Richard J. Reynolds, Maria I. Danila, Jeffrey R. Curtis, Antony Rosen and S. Louis Bridges Source Type: research

Power Doppler ultrasonographic assessment of the joint-draining lymph node complex in rheumatoid arthritis: a prospective, proof-of-concept study on treatment with tumor necrosis factor inhibitors
Emerging research on the mechanisms of disease chronicity in experimental arthritis has included a new focus on the draining lymph node (LN). Here, we combined clinical-serological analyses and power Doppler u... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 22, 2016 Category: Rheumatology Authors: Antonio Manzo, Francesca Benaglio, Barbara Vitolo, Chandra Bortolotto, Francesca Zibera, Monica Todoerti, Claudia Alpini, Serena Bugatti, Roberto Caporali, Fabrizio Calliada and Carlomaurizio Montecucco Source Type: research

The association of low complement with disease activity in systemic sclerosis: a prospective cohort study
In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ( ‘hypocomplementaemia’) is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 22, 2016 Category: Rheumatology Authors: James Esposito, Zoe Brown, Wendy Stevens, Joanne Sahhar, Candice Rabusa, Jane Zochling, Janet Roddy, Jennifer Walker, Susanna M. Proudman and Mandana Nikpour Source Type: research

Childhood hospitalisation with infections and later development of ankylosing spondylitis: a national case-control study
The role of environmental exposures in the pathogenesis of ankylosing spondylitis (AS) remains unclear. In particular, two types of exposures have been suspected to play a role: mechanical stress and infection... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 22, 2016 Category: Rheumatology Authors: Ulf Lindstr öm, Sofia Exarchou, Elisabeth Lie, Mats Dehlin, Helena Forsblad-d’Elia, Johan Askling and Lennart Jacobsson Source Type: research

Body mass index and extent of MRI-detected inflammation: opposite effects in rheumatoid arthritis versus other arthritides and asymptomatic persons
In the population a high body mass index (BMI) has been associated with slightly increased inflammatory markers. Within rheumatoid arthritis (RA), however, a high BMI has been associated with less radiographic... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 22, 2016 Category: Rheumatology Authors: Lukas Mangnus, Wouter P. Nieuwenhuis, Hanna W. van Steenbergen, Tom W. J. Huizinga, Monique Reijnierse and Annette H. M. van der Helm-van Mil Source Type: research

Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue
Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 20, 2016 Category: Rheumatology Authors: Sanna Turunen, Johanna Huhtakangas, Tomi Nousiainen, Maarit Valkealahti, Jukka Melkko, Juha Risteli and Petri Lehenkari Source Type: research

Identification of subgroups of inflammatory and degenerative MRI findings in the spine and sacroiliac joints: a latent class analysis of 1037 patients with persistent low back pain
The aim of this study was to investigate subgroups of magnetic resonance imaging (MRI) findings for the spine and sacroiliac joints (SIJs) using latent class analysis (LCA), and to investigate whether these su... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 13, 2016 Category: Rheumatology Authors: Bodil Arnbak, Rikke Kr üger Jensen, Claus Manniche, Oliver Hendricks, Peter Kent, Anne Grethe Jurik and Tue Secher Jensen Source Type: research

Comment to Ruiyu Liu et al.: Comparative analysis of gene expression profiles in normal hip human cartilage and cartilage from patients with necrosis of the femoral head
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 13, 2016 Category: Rheumatology Authors: Zeling Long, Tianlong Huang and Wanchun Wang Source Type: research

Inflammatory cell infiltrates in the heart of patients with coronary artery disease with and without inflammatory rheumatic disease: a biopsy study
The cause of premature cardiovascular disease (CVD) in inflammatory rheumatic diseases (IRDs) has not been fully elucidated. As inflammation may play a role, we wanted to compare the occurrence and extent of i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2016 Category: Rheumatology Authors: Jacqueline K. Andersen, Ingvild Oma, Richard A. Prayson, Ingjerd Lien Kvelstad, Sven Martin Almdahl, Morten Wang Fagerland and Ivana Hollan Source Type: research

Screening for peptides targeted to IL-7R α for molecular imaging of rheumatoid arthritis synovium
Interleukin-7 receptor alpha (IL-7R α) represents a biomarker with potential applications in rheumatoid arthritis (RA) diagnosis and therapy. We have therefore searched by phage display potential IL-7Rα specifi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2016 Category: Rheumatology Authors: Carmen Burtea, Sophie Laurent, Tuba Sanli, Deborah Fanfone, Aude Devalckeneer, S ébastien Sauvage, Marie-Claire Beckers, Sandrine Rorive, Isabelle Salmon, Luce Vander Elst, Bernard R. Lauwerys and Robert N. Muller Source Type: research

Sequential high-content profiling of the IgG-autoantibody repertoire reveals novel antigens in rheumatoid arthritis
The aim was to identify novel diagnostic autoantibody candidates for rheumatoid arthritis (RA) by comprehensive screening for autoreactivity. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2016 Category: Rheumatology Authors: Stefan Vordenb äumen, Angelika Lueking, Petra Budde, Hans-Dieter Zucht, Heike Goehler, Ralph Brinks, Rebecca Fischer-Betz, Jutta Richter, Ellen Bleck, Jacqueline Detert, Hans-Eckhard Langer, Anne Sörgel, Gerd-Rüdiger Burmester, Peter Schulz-Knappe and Source Type: research

Familial risk of systemic sclerosis and co-aggregation of autoimmune diseases in affected families
Systemic sclerosis (SSc) is a rare and devastating disease affecting skin and internal organs. Familial aggregation of SSc and co-aggregation with other autoimmune diseases is rarely reported. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2016 Category: Rheumatology Authors: Chang-Fu Kuo, Shue-Fen Luo, Kuang-Hui Yu, Lai-Chu See, Weiya Zhang and Michael Doherty Source Type: research

Erratum to: Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2016 Category: Rheumatology Authors: Jeffrey N. Miner, Philip K. Tan, David Hyndman, Sha Liu, Cory Iverson, Payal Nanavati, David T. Hagerty, Kimberly Manhard, Zancong Shen, Jean-Luc Girardet, Li-Tain Yeh, Robert Terkeltaub and Barry Quart Source Type: research

The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis
The complement system is suggested to be involved in the pathogenesis of osteoarthritis (OA), and proinflammatory cytokines may play a role in OA development by inducing proteases. The association between comp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2016 Category: Rheumatology Authors: Andr é Struglics, Marcin Okroj, Per Swärd, Richard Frobell, Tore Saxne, L. Stefan Lohmander and Anna M. Blom Source Type: research

Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Long noncoding RNAs (lncRNAs) have recently received wide attention as key molecules that mediate a variety of physiological and pathological processes by regulating gene expression; however, knowledge of lncR... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2016 Category: Rheumatology Authors: Yu Zhang, Yu-Zhong Xu, Ning Sun, Jian-Hong Liu, Fang-Fang Chen, Xiao-Long Guan, Ang Li, Fei Wang, Qin-Fei Zhao, Hai-Yong Wang, Shu-Sheng Song, Wei Yu, Jian-Ning Zhao and Xiao-Jun Li Source Type: research

A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease
In this study, we evaluated how these TLR4 ligands may drive pathogenic... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2016 Category: Rheumatology Authors: Eric Hatterer, Limin Shang, Pierre Simonet, Suzanne Herren, Bruno Daubeuf, St éphanie Teixeira, James Reilly, Greg Elson, Robert Nelson, Cem Gabay, Jeremy Sokolove, Iain B. McInnes, Marie Kosco-Vilbois, Walter Ferlin, Emmanuel Monnet and Cristina De Min Source Type: research

Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study
Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2016 Category: Rheumatology Authors: Claudio Corallo, Maurizio Cutolo, Bashar Kahaleh, Gianluca Pecetti, Antonio Montella, Chiara Chirico, Stefano Soldano, Ranuccio Nuti and Nicola Giordano Source Type: research

Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis
Autoantibodies such as anti-citrullinated protein antibodies (ACPA) are major risk factors for articular bone destruction from the earliest phases of rheumatoid arthritis (RA). The aim of the current study was... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2016 Category: Rheumatology Authors: Serena Bugatti, Laura Bogliolo, Barbara Vitolo, Antonio Manzo, Carlomaurizio Montecucco and Roberto Caporali Source Type: research

Ultrasonographic assessment of bone erosions in the different subtypes of systemic lupus erythematosus arthritis: comparison with computed tomography
The aim was to determine the accuracy of high-resolution ultrasonography (US) for detecting erosion in the metacarpophalangeal (MCP) and wrist joints of patients with different subtypes of systemic lupus eryth... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 4, 2016 Category: Rheumatology Authors: Matteo Piga, Luca Saba, Alessandra Gabba, Mattia Congia, Antonella Balestrieri, Alessandro Mathieu and Alberto Cauli Source Type: research

A novel DNA/histone H4 peptide complex detects autoantibodies in systemic lupus erythematosus sera
The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 4, 2016 Category: Rheumatology Authors: Filomena Panza, Maria Claudia Alcaro, Fiorella Petrelli, Francesca Angelotti, Federico Pratesi, Paolo Rovero and Paola Migliorini Source Type: research