Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity
Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single-nucleotide polymorphisms (SNPs) have been identified as associated with both alcohol consumption and serum urate or gout in sep... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2024 Category: Rheumatology Authors: Min H Chuah, Megan P Leask, Ruth K Topless, Gregory D Gamble, Nicholas A Sumpter, Lisa K Stamp, Tony R Merriman and Nicola Dalbeth Tags: Research Source Type: research
Macrophage subpopulations in pediatric patients with lupus nephritis and other inflammatory diseases affecting the kidney
Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pe... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2024 Category: Rheumatology Authors: Mira Sandersfeld, Maike B üttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz and Christoph Daniel Tags: Research Source Type: research
Patients with obesity have more inflamed joints and higher CRP levels during the disease course in ACPA-positive RA but not in ACPA-negative RA
Obese RA patients have higher disease activity scores (DAS). Previous research showed that obese RA patients have higher tender joint count (TJC) and VAS general health. However, it remains unclear whether DAS... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 7, 2024 Category: Rheumatology Authors: N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil and H. W. van Steenbergen Tags: Research Source Type: research
Interaction of 5-HTTLPR and SLE disease status on resting-state brain function
Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is a common clinical manifestation. In SLE patients, cerebral function is a more sensitive predictor of central nervous system damage, and abn... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 31, 2024 Category: Rheumatology Authors: Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng and Jian Xu Tags: Research Source Type: research
Correction: CircPTPN22 modulates T ‑cell activation by sponging miR‑4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 31, 2024 Category: Rheumatology Authors: Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao and Jun Tang Tags: Correction Source Type: research
Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults
The association between non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA) has not been well elucidated. The aim of the present study was to investigate the association between NAFLD and OA in t... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 31, 2024 Category: Rheumatology Authors: Yu Lu, Jianyu Zhang, Hejun Li and Ting Li Tags: Research Source Type: research
Induction of cervical disc degeneration and discogenic pain by low concentration Propionibacterium acnes infection: an in vivo animal study
In this study, an animal model of cervical disc degeneration and discogenic neck pain i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 31, 2024 Category: Rheumatology Authors: Jie Li, Hui Li, Yilei Chen, Dikai Bei, Bao Huang, Kaifeng Gan, Peiming Sang, Junhui Liu, Zhi Shan, Jian Chen, Fengdong Zhao and Binhui Chen Tags: Research Source Type: research
Apolipoproteins and the risk of giant cell arteritis —a nested case–control study
The etiology of giant cell arteritis (GCA) and its predictors are incompletely understood. Previous studies have indicated reduced risk of future development of GCA in individuals with obesity and/or diabetes ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 27, 2024 Category: Rheumatology Authors: Karin Wadstr öm, Lennart T. H. Jacobsson, Aladdin J. Mohammad, Kenneth J. Warrington, Eric L. Matteson and Carl Turesson Tags: Research Source Type: research
Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 25, 2024 Category: Rheumatology Authors: Jianhua Zhang, Hao Cai, Weiwei Sun, Weijie Wu, Yunyi Nan, Yingchen Ni, Xinyuan Wu, Minhao Chen, Hua Xu and Youhua Wang Tags: Research Source Type: research
Exploring the causal association between rheumatoid arthritis and the risk of cervical cancer: a two-sample Mendelian randomization study
This study aims to investigate the association b... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 23, 2024 Category: Rheumatology Authors: Minxian Xu, Huan Chen, Tao Tan, Kaihong Xie, Hui Xie and Qing Li Tags: Research Source Type: research
PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis
PD-1 is an immune checkpoint on T cells, and interventions to block this receptor result in T cell activation and enhanced immune response to tumors and pathogens. Reciprocally, despite a decade of research, a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 22, 2024 Category: Rheumatology Authors: Johanna Straube, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Yevgeniya Gartshteyn, Brian S. Henick, Matthew A. Dragovich and Adam Mor Tags: Research Source Type: research
Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis
Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation in primary osteoarthritis (OA), a common age-associated joint disease. EV subpopulati... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 22, 2024 Category: Rheumatology Authors: Anne-Mari Mustonen, Mari Palviainen, Laura S äisänen, Lauri Karttunen, Sylvain Tollis, Amir Esrafilian, Jusa Reijonen, Petro Julkunen, Pia R-M Siljander, Heikki Kröger, Jussi Mäki, Jari Arokoski and Petteri Nieminen Tags: Research Source Type: research
Correction: Iguratimod attenuated fbrosis in systemic sclerosis via targeting early growth response 1 expression
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 22, 2024 Category: Rheumatology Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan Tags: Correction Source Type: research
Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 20, 2024 Category: Rheumatology Authors: Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng and Richard Bucala Tags: Research Source Type: research
Association of biochemical markers with bone marrow lesion changes on imaging —data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium
To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relation... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 18, 2024 Category: Rheumatology Authors: Shirley P. Yu, Leticia A. Deveza, Virginia B. Kraus, Morten Karsdal, Anne-Christine Bay-Jensen, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Christoph Ladel, Venkatesha Bhagavath and David J. Hunter Tags: Research Source Type: research
