Thinking BIG rheumatology: how to make functional genomics data work for you
High-throughput sequencing assays have become an increasingly common part of biological research across multiple fields. Even as the resulting sequences pile up in public databases, it is not always obvious ho... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 12, 2018 Category: Rheumatology Authors: Deborah R. Winter Tags: Review Source Type: research

Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis
We have previously reported that adiponectin (AD), an adipokine that is secreted by adipocytes, correlates well with progressive bone erosion in rheumatoid arthritis (RA). The exact mechanism of AD in promotin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2018 Category: Rheumatology Authors: Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan and Miaojia Zhang Tags: Research article Source Type: research

IL-1 family cytokines and soluble receptors in systemic lupus erythematosus
Dysregulated production of cytokines has a critical role in systemic lupus. The aim of this work is to identify, by a comprehensive analysis of IL-1 family cytokines and receptors in serum, correlation between... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2018 Category: Rheumatology Authors: Paola Italiani, Maria Laura Manca, Francesca Angelotti, Daniela Melillo, Federico Pratesi, Ilaria Puxeddu, Diana Boraschi and Paola Migliorini Tags: Research article Source Type: research

Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone Fc γRIIB-deficient mice
Previously we established an arthritis-prone Fc γRIIB-deficient mouse strain (designated KO1). Anti-mouse CD11b mAb (5C6) has been reported to inhibit the recruitment of peripheral CD11b+ myelomonocytic cells from... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2018 Category: Rheumatology Authors: Mareki Ohtsuji, Qingshun Lin, Hideki Okazaki, Kazuko Takahashi, Hirofumi Amano, Hideo Yagita, Hiroyuki Nishimura and Sachiko Hirose Tags: Research article Source Type: research

Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013
Anterior uveitis is the most common extra-articular manifestation of ankylosing spondylitis (AS). AS-related anterior uveitis frequently presents as acute, recurrent iridocyclitis; therefore, AS is often initi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 7, 2018 Category: Rheumatology Authors: Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee and Hyeong Gon Yu Tags: Research article Source Type: research

Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner
The anti-inflammatory effect of abatacept is most pronounced in patients with high-titer autoantibodies (including anticitrullinated protein antibodies [ACPA] and rheumatoid factor [RF]). Considering that auto... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 7, 2018 Category: Rheumatology Authors: Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang and Georg Schett Tags: Research article Source Type: research

The new aims and scope of Arthritis Research & Therapy
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 7, 2018 Category: Rheumatology Authors: Christopher D. Buckley and Harris Perlman Tags: Editorial Source Type: research

Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells
Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. A recent study demonstrated the transdifferentiation... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 7, 2018 Category: Rheumatology Authors: Ryosuke Saigusa, Yoshihide Asano, Takashi Taniguchi, Megumi Hirabayashi, Kouki Nakamura, Shunsuke Miura, Takashi Yamashita, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Ayumi Yoshizaki, Maria Trojanowska and Shinichi Sato Tags: Research article Source Type: research

Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway
In addition to the kidney, the intestine is one of the most important organs involved in uric acid excretion. However, the mechanism of urate excretion in the intestine remains unclear. Therefore, the relation... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 7, 2018 Category: Rheumatology Authors: Mo Chen, Xiaoyong Lu, Ci Lu, Ning Shen, Yujie Jiang, Menglu Chen and Huaxiang Wu Tags: Research article Source Type: research

Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?
At present, there are no prognostic parameters unequivocally predicting treatment failure in early rheumatoid arthritis (RA) patients. We investigated whether baseline ultrasonography (US) findings of joints, ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 30, 2018 Category: Rheumatology Authors: D. F. Ten Cate, J. W. G. Jacobs, W. A. A. Swen, J. M. W. Hazes, M. H. de Jager, N. M. Basoski, C. J. Haagsma, J. J. Luime and A. H. Gerards Tags: Research article Source Type: research

Treatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents
Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic disease. Despite its good response to steroid therapy, its treatment protocol is not standardized and the long-te... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 30, 2018 Category: Rheumatology Authors: Xia Hong, Yan-Yan Zhang, Wei Li, Yan-Ying Liu, Zhen Wang, Yan Chen, Yan Gao, Zhi-Peng Sun, Xin Peng, Jia-Zeng Su, Zhi-Gang Cai, Lei Zhang, Jing He, Li-Min Ren, Hong-Yu Yang, Zhan-Guo Li & hellip; Tags: Research article Source Type: research

Systemic sclerosis associated interstitial lung disease - individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group
Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliora... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 30, 2018 Category: Rheumatology Authors: Sabine Adler, D örte Huscher, Elise Siegert, Yannick Allanore, László Czirják, Francesco DelGaldo, Christopher P. Denton, Oliver Distler, Marc Frerix, Marco Matucci-Cerinic, Ulf Mueller-Ladner, Ingo-Helmut Tarner, Gabriele Valentini, Ulrich A. Walker, Tags: Research article Source Type: research

Anti-CCP-positive patients with RA have a higher 10-year probability of fracture evaluated by FRAX ®: a registry study of RA with osteoporosis/fracture
Positive anticyclic citrullinated peptide (anti-CCP+) is associated with bone loss in patients with rheumatoid arthritis (RA). However, whether overall positivity or specific levels of anti-CCP are associated ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 30, 2018 Category: Rheumatology Authors: Tien-Tsai Cheng, Shan-Fu Yu, Fu-Mei Su, Yin-Chou Chen, Ben Yu-Jih Su, Wen-Chan Chiu, Chung-Yuan Hsu, Jia-Feng Chen, Chi-Hua Ko and Han-Ming Lai Tags: Research article Source Type: research

Synovial IL-9 facilitates neutrophil survival, function and differentiation of Th17 cells in rheumatoid arthritis
Role of Th9 cells and interleukin-9 (IL-9) in human autoimmune diseases such as psoriasis and ulcerative colitis has been explored only very recently. However, their involvement in human rheumatoid arthritis (... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 30, 2018 Category: Rheumatology Authors: Kaustav Chowdhury, Uma Kumar, Soumabha Das, Jaydeep Chaudhuri, Prabin Kumar, Maumita Kanjilal, Parashar Ghosh, Geetabali Sircar, Ravi Kiran Basyal, Uma Kanga, Santu Bandyopadhaya and Dipendra Kumar Mitra Tags: Research article Source Type: research

Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab
This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 25, 2018 Category: Rheumatology Authors: Ana ïs Huwart, Florent Garrigues, Sandrine Jousse-Joulin, Thierry Marhadour, Dewi Guellec, Divi Cornec, Maelenn Gouillou, Alain Saraux and Valérie Devauchelle-Pensec Tags: Research article Source Type: research

BANK1 alters B cell responses and influences the interactions between B cells and induced T regulatory cells in mice with collagen-induced arthritis
Functional variants of the B cell gene, B cell scaffold protein with ankyrin repeats 1 (BANK1) contribute to rheumatoid arthritis (RA) susceptibility, but their influences on B cell responses are unclear. More... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 25, 2018 Category: Rheumatology Authors: Jie Yang, Jie Ren, Yiming Yang, Juan Sun, Xiaohui Zhou, Shucong Zheng, Dandan Xuan, Yu Xue, Huimin Fan, Jiong Zhang, Hejian Zou, Weiguo Wan and Ning Kong Tags: Research article Source Type: research

Highly selective inhibition of Bruton ’s tyrosine kinase attenuates skin and brain disease in murine lupus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathoge... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 25, 2018 Category: Rheumatology Authors: Samantha A. Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M. Cuda, Hadijat M. Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S. Fine, Elliott Klein, Meera Ramanujam and Chaim Putterman Tags: Research article Source Type: research

Predictors of remission with etanercept-methotrexate induction therapy and loss of remission with etanercept maintenance, reduction, or withdrawal in moderately active rheumatoid arthritis: results of the PRESERVE trial
The aim was to analyze characteristics that predict remission induction and subsequent loss of remission in patients with moderately active rheumatoid arthritis (RA) who received full-dose combination etanerce... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 16, 2018 Category: Rheumatology Authors: Josef S. Smolen, Annette Szumski, Andrew S. Koenig, Thomas V. Jones and Lisa Marshall Tags: Research article Source Type: research

Are we there yet? An update on transitional care in rheumatology
Significant progress has been made in the understanding of transitional care in rheumatology over the last few decades, yet universal implementation has not been realised and unmet needs continue to be reporte... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 11, 2018 Category: Rheumatology Authors: Janet E. McDonagh and Albert Farre Tags: Commentary Source Type: research

Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis
The aim was to study urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) as biomarkers of renal disease in systemic lupus erythematosus (SLE). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 11, 2018 Category: Rheumatology Authors: Chi Chiu Mok, Samar Soliman, Ling Yin Ho, Fatma A. Mohamed, Faten Ismail Mohamed and Chandra Mohan Tags: Research article Source Type: research

The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease
Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicent... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 11, 2018 Category: Rheumatology Authors: Yumiko Sugiyama, Ryusuke Yoshimi, Maasa Tamura, Mitsuhiro Takeno, Yosuke Kunishita, Daiga Kishimoto, Yuji Yoshioka, Kouji Kobayashi, Kaoru Takase-Minegishi, Toshiyuki Watanabe, Naoki Hamada, Hideto Nagai, Naomi Tsuchida, Yutaro Soejima, Hiroto Nakano, Rei Tags: Research article Source Type: research

Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?
The objective of this study was... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 10, 2018 Category: Rheumatology Authors: M. Javad Wahadat, Iris L. A. Bodewes, Naomi I. Maria, Cornelia G. van Helden-Meeuwsen, Annette van Dijk-Hummelman, Eline C. Steenwijk, Sylvia Kamphuis and Marjan A. Versnel Tags: Research article Source Type: research

The epidemiology of psoriatic arthritis in Israel – a population-based study
There is limited information on the epidemiology of psoriatic arthritis (PsA) in general and in Middle Eastern populations in particular. The aims of this study were to estimate the prevalence and incidence ra... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 2, 2018 Category: Rheumatology Authors: Lihi Eder, Arnon Dov Cohen, Ilan Feldhamer, Sari Greenberg-Dotan, Erez Batat and Devy Zisman Tags: Research article Source Type: research

Profiling microRNAs in individuals at risk of progression to rheumatoid arthritis
This study a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 22, 2017 Category: Rheumatology Authors: L. Ouboussad, L. Hunt, E. M. A. Hensor, J. L. Nam, N. A. Barnes, P. Emery, M. F. McDermott and M. H. Buch Tags: Research article Source Type: research

Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study
In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we show... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 22, 2017 Category: Rheumatology Authors: Isabel Ferreira, Sara Croca, Maria Gabriella Raimondo, Manjit Matharu, Sarah Miller, Ian Giles, David Isenberg, Yiannis Ioannou, John G. Hanly, Murray B. Urowitz, Nicole Anderson, Cynthia Aranow, Anca Askanase, Sang-Cheol Bae, Sasha Bernatsky, Ian N. Bruc Tags: Research article Source Type: research

Efficacy, safety, and tolerability of secukinumab in patients with active ankylosing spondylitis: a randomized, double-blind phase 3 study, MEASURE 3
Secukinumab, an anti –interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) in two phase 3 studies (MEASURE 1 and MEASURE 2). Here, we present 52-week results from ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 22, 2017 Category: Rheumatology Authors: Karel Pavelka, Alan Kivitz, Eva Dokoupilova, Ricardo Blanco, Marco Maradiaga, Hasan Tahir, Luminita Pricop, Mats Andersson, Aimee Readie and Brian Porter Tags: Research article Source Type: research

Nonradiographic axial spondyloarthritis: clinical and therapeutic relevance
Current classification criteria for axial spondyloarthritis (axSpA) provide for the inclusion of patients with a wide range of presentations and manifestations. While not considered a formal subclassification,... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 22, 2017 Category: Rheumatology Authors: Nilasha Ghosh and Eric M. Ruderman Tags: Review Source Type: research

CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF- κB signaling pathway in osteoarthritis synovial fibroblasts
Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage, synovium, and subchondral bone and is the leading cause of disability in older populations. Specific diagnostic biomarkers are la... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 21, 2017 Category: Rheumatology Authors: Sheng-Mou Hou, Chun-Han Hou and Ju-Fang Liu Tags: Research article Source Type: research

The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial
The use of allopurinol in people with chronic kidney disease (CKD) remains one of the most controversial areas in gout management. The aim of this study was to determine the effect of baseline kidney function ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 21, 2017 Category: Rheumatology Authors: Lisa K. Stamp, Peter T. Chapman, Murray Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake and Nicola Dalbeth Tags: Research article Source Type: research

Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
The phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution from MCTD to ano... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 21, 2017 Category: Rheumatology Authors: Silje Reiseter, Ragnar Gunnarsson, Jukka Corander, Joanna Haydon, May Brit Lund, Trond Mogens Aal økken, Eli Taraldsrud, Siri Opsahl Hetlevik and Øyvind Molberg Tags: Research article Source Type: research

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
Atsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in multiple murine models of inflammatory arthritis . A... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 19, 2017 Category: Rheumatology Authors: Jian-lu Wei, Wenyu Fu, Yuan-jing Ding, Aubryanna Hettinghouse, Matin Lendhey, Ran Schwarzkopf, Oran D. Kennedy and Chuan-ju Liu Tags: Research article Source Type: research

Association between ultrasound-detected synovitis and knee pain: a population-based case –control study with both cross-sectional and follow-up data
This study aimed to examine whether ultrasonography-detected synovial changes ass... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 19, 2017 Category: Rheumatology Authors: Aliya Sarmanova, Michelle Hall, Gwen S. Fernandes, Archan Bhattacharya, Ana M. Valdes, David A. Walsh, Michael Doherty and Weiya Zhang Tags: Research article Source Type: research

The biological functions of DNA: from the sublime to the slime
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 15, 2017 Category: Rheumatology Authors: David S. Pisetsky Tags: Editorial Source Type: research

The risk of malignancy and its incidence in early rheumatoid arthritis patients treated with biologic DMARDs
Treatment with disease-modifying anti-rheumatic drugs (DMARDs) has raised concerns about the risk of malignancies in rheumatoid arthritis (RA) patients. However, the association between biologic DMARDs (bDMARD... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 15, 2017 Category: Rheumatology Authors: Soo-Kyung Cho, Jiyoung Lee, Minkyung Han, Sang-Cheol Bae and Yoon-Kyoung Sung Tags: Research article Source Type: research

Incidence of giant cell arteritis in Western Norway 1972 –2012: a retrospective cohort study
Giant cell arteritis (GCA) is the most common systemic vasculitis in persons older than 50  years. The highest incidence rates of the disease have been reported in Scandinavian countries. Our objective was to d... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 15, 2017 Category: Rheumatology Authors: L. K. Brekke, A. P. Diamantopoulos, B-T. Fevang, J. A βmus, E. Esperø and C. G. Gjesdal Tags: Research article Source Type: research

Use of a baseline risk score to identify the risk of serious infectious events in patients with rheumatoid arthritis during certolizumab pegol treatment
The risk of serious infectious events (SIEs) is increased in patients with rheumatoid arthritis (RA). The aim of this study was to develop an age-adjusted comorbidity index (AACI) to predict, using baseline ch... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 15, 2017 Category: Rheumatology Authors: Jeffrey R. Curtis, Kevin Winthrop, Cathy O ’Brien, Matladi N. Ndlovu, Marc de Longueville and Boulos Haraoui Tags: Research article Source Type: research

Factors associated with the 6-minute walk distance in patients with systemic sclerosis
There is an ongoing debate regarding the relevance of the 6-minute walking distance (6MWD) in systemic sclerosis (SSc) assessment, widely used as a usual test in these patients as well as an outcome measure in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 15, 2017 Category: Rheumatology Authors: S ébastien Sanges, Jonathan Giovannelli, Vincent Sobanski, Sandrine Morell-Dubois, Hélène Maillard, Marc Lambert, Céline Podevin, Nicolas Lamblin, Pascal De Groote, Jean-François Bervar, Thierry Perez, Régis Matran, Martine Rémy-Jardin, Pierre-Yves Tags: Research article Source Type: research

Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?
Clinical guidelines recommend knee muscle strengthening exercises to improve physical function. However, the amount of knee muscle strength increase needed for clinically relevant improvements in physical func... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 8, 2017 Category: Rheumatology Authors: Michelle Hall, Rana S. Hinman, Martin van der Esch, Marike van der Leeden, Jessica Kasza, Tim V. Wrigley, Ben R. Metcalf, Fiona Dobson and Kim L. Bennell Tags: Research article Source Type: research

VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes
In addition to activated T cells, the immune checkpoint inhibitor “V domain-containing Ig suppressor of T-cell activation” (VISTA) is expressed by myeloid cell types, including macrophages and neutrophils. The... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 8, 2017 Category: Rheumatology Authors: Sabrina Ceeraz, Susan K. Eszterhas, Petra A. Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti and Roy A. Fava Tags: Research article Source Type: research

Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis
We previously demonstrated that fasciitis is a common lesion in dermatomyositis (DM) and that DM-associated fasciitis is detectable, as the result of the increased vascularity in the fascia, by power Doppler u... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 8, 2017 Category: Rheumatology Authors: Ken Yoshida, Haruyasu Ito, Kazuhiro Furuya, Taro Ukichi, Kentaro Noda and Daitaro Kurosaka Tags: Research article Source Type: research

Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study
Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 8, 2017 Category: Rheumatology Authors: Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan G öthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson and Helena Forsblad-d’Elia Tags: Research article Source Type: research

Rheumatoid arthritis bone marrow environment supports Th17 response
Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA, where pathological processes from “outsid... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 8, 2017 Category: Rheumatology Authors: Ewa Kuca-Warnawin, Weronika Kurowska, Monika Prochorec-Sobieszek, Anna Radzikowska, Tomasz Burakowski, Urszula Skalska, Magdalena Massalska, Magdalena Pleba ńczyk, Barbara Małdyk-Nowakowska, Iwona Słowińska, Robert Gasik and Włodzimierz Maśliński Tags: Research article Source Type: research

Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus
In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 6, 2017 Category: Rheumatology Authors: Myriam Martin, Karolina I. Smol ąg, Albin Björk, Birgitta Gullstrand, Marcin Okrój, Jonatan Leffler, Andreas Jönsen, Anders A. Bengtsson and Anna M. Blom Tags: Research article Source Type: research

Patients and surgeons provide endorsement of core domains for total joint replacement clinical trials
Our objective in this study was to examine whether stakeholders further endorse the core domain set proposed by the Outcome Measures in Rheumatology Trials (OMERACT) total joint replacement (TJR) working group. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 6, 2017 Category: Rheumatology Authors: Anh Hoang, Susan M. Goodman, Iris Y. Navarro-Mill án, Lisa A. Mandl, Mark P. Figgie, Mathias P. Bostrom, Douglas E. Padgett, Peter K. Sculco, Alexander S. McLawhorn and Jasvinder A. Singh Tags: Research article Source Type: research

Role of endoplasmic reticulum stress in the protective effects of PPAR β/δ activation on endothelial dysfunction induced by plasma from patients with lupus
We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPAR β/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) inv... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 6, 2017 Category: Rheumatology Authors: Marta Toral, Rosario Jim énez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio and Juan Duarte Tags: Research article Source Type: research

Comparison of 2002 AECG and 2016 ACR/EULAR classification criteria and added value of salivary gland ultrasonography in a patient cohort with suspected primary Sj ögren’s syndrome
The objective was to evaluate concordance between 2002 American-European Consensus Group (AECG) and 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteri... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 6, 2017 Category: Rheumatology Authors: Ma ëlle Le Goff, Divi Cornec, Sandrine Jousse-Joulin, Dewi Guellec, Sebastian Costa, Thierry Marhadour, Rozenn Le Berre, Steeve Genestet, Béatrice Cochener, Sylvie Boisrame-Gastrin, Yves Renaudineau, Jacques-Olivier Pers, Alain Saraux and Valérie Devau Tags: Research article Source Type: research

Prediction of progression of damage to articular cartilage 2  years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study
We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL)... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 6, 2017 Category: Rheumatology Authors: Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hiroaki Yoshida, Robin Poole and Naoki Ishiguro Tags: Research article Source Type: research

The role of aberrant expression of T cell miRNAs affected by TNF- α in the immunopathogenesis of rheumatoid arthritis
Tumor necrosis factor-alpha (TNF- α) can cause diverse T cell dysfunctions in patients with rheumatoid arthritis (RA). It is involved in the regulation of microRNAs (miRNAs) expression in different cell types. ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 1, 2017 Category: Rheumatology Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang and Ming-Chi Lu Tags: Research article Source Type: research

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases
The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 1, 2017 Category: Rheumatology Authors: Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Ichiro Mizushima, Shoko Matsui, Yuhei Fujisawa, Satoshi Hara, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa and Mitsuhiro Kawano Tags: Research article Source Type: research

Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis
Adipokines are bioactive hormones secreted by adipose tissues. Resistin, an adipokine, plays important roles in the regulation of insulin resistance and inflammation. Resistin levels are known to be increased ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 1, 2017 Category: Rheumatology Authors: Hiroshi Sato, Sei Muraoka, Natsuko Kusunoki, Shotaro Masuoka, Soichi Yamada, Hideaki Ogasawara, Toshio Imai, Yoshikiyo Akasaka, Naobumi Tochigi, Hiroshi Takahashi, Kazuaki Tsuchiya, Shinichi Kawai and Toshihiro Nanki Tags: Research article Source Type: research