Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity
To compare the 10-year structural and functional prognosis between patients in sustained remission versus patients in sustained low disease activity (LDA) in early rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 20, 2023 Category: Rheumatology Authors: Adeline Ruyssen-Witrand, Gregory Guernec, Julia Dupont, Diane Lapuyade, Fr édéric Lioté, Olivier Vittecoq, Yannick Degboé and Arnaud Constantin Tags: Research Source Type: research
Commonalities and differences in set-up and data collection across European spondyloarthritis registries — results from the EuroSpA collaboration
In European axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) clinical registries, we aimed to investigate commonalities and differences in (1) set-up, clinical data collection; (2) data availabili... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 19, 2023 Category: Rheumatology Authors: Louise Linde, Lykke M. Ørnbjerg, Simon H. Rasmussen, Thorvardur Jon Love, Anne Gitte Loft, Jakub Závada, Jiří Vencovský, Karin Laas, Dan Nordstrom, Tuulikki Sokka-Isler, Bjorn Gudbjornsson, Gerdur Gröndal, Florenzo Iannone, Roberta Ramonda, Pasoon H Tags: Research Source Type: research
CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
Circular RNAs are involved in autoimmune disease pathogenesis. Our previous study indicated that circPTPN22 is involved in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthrit... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 19, 2023 Category: Rheumatology Authors: Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao and Jun Tang Tags: Research Source Type: research
Interleukin-37: associations of plasma levels and genetic variants in gout
IL-37 is an anti-inflammatory cytokine involved in inflammatory and autoimmune diseases. We aimed to investigate the association between IL-37 genetic variants, IL-37 plasma levels, and various clinical phases... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 18, 2023 Category: Rheumatology Authors: Lucie Andres Cerezo, Ad éla Navrátilová, Hana Hulejová, Markéta Pavlíková, Jakub Závada, Karel Pavelka, Ladislav Šenolt and Blanka Stiburkova Tags: Research Source Type: research
Janus kinase inhibitor, tofacitinib, in refractory juvenile dermatomyositis: a retrospective multi-central study in China
Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. Some patients remain in an active state even though they were administrated with a combination of corticosteroid and methotrexate. Existing resea... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 18, 2023 Category: Rheumatology Authors: Junmei Zhang, Li Sun, XinWei Shi, Shipeng Li, Cuihua Liu, Xiaoqing Li, Meiping Lu, Jianghong Deng, Xiaohua Tan, Wanzhen Guan, Guomin Li, Xinran Wen, Ping Liu and Caifeng Li Tags: Research Source Type: research
High BMI is associated with lower TNF- α inhibitor serum trough levels and higher disease activity in patients with axial spondyloarthritis
TNF- α inhibitor (TNFi) serum trough levels have previously been found to be related to disease activity in axial spondyloarthritis (axSpA). However, most research regarding serum trough levels has been conduct... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 17, 2023 Category: Rheumatology Authors: Liseth de Wolff, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma and Anneke Spoorenberg Tags: Research Source Type: research
A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of sarilumab in patients with giant cell arteritis
Giant cell arteritis (GCA) is primarily treated with glucocorticoids (GCs), which have substantial toxicity. Tocilizumab, an interleukin-6-receptor inhibitor (IL-6Ri), showed beneficial effects in GCA, leading... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 16, 2023 Category: Rheumatology Authors: Wolfgang A. Schmidt, Bhaskar Dasgupta, Jennifer Sloane, Angeliki Giannelou, Yuqing Xu, Sebastian H. Unizony, Sarah L. Mackie, Miguel A. Gonzalez-Gay, Robert Spiera, Kenneth J. Warrington, Peter M. Villiger, Michael C. Nivens, Bolanle Akinlade, Yong Lin, F Tags: Research Source Type: research
Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus
In systemic lupus erythematosus (SLE), autoreactive B cells are thought to develop by-passing immune checkpoints and contribute to its pathogenesis. Toll-like receptor (TLR) 7 and 9 signaling have been implica... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 16, 2023 Category: Rheumatology Authors: Ken Yasaka, Tomohide Yamazaki, Hiroko Sato, Tsuyoshi Shirai, Minkwon Cho, Koji Ishida, Koyu Ito, Tetsuhiro Tanaka, Kouetsu Ogasawara, Hideo Harigae, Tomonori Ishii and Hiroshi Fujii Tags: Research Source Type: research
Comprehensive analysis of serum exosome-derived lncRNAs and mRNAs from patients with rheumatoid arthritis
Serum exosomes play important roles in intercellular communication and are promising biomarkers of several autoimmune diseases. However, the biological functions and potential clinical importance of long non-c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 16, 2023 Category: Rheumatology Authors: Li Xue, Biao Wang, Xueyi Li, Jianhong Zhu, Wei Wang, Fang Huang, Xiaofei Wang, Yaofeng Jin, Chaoliang Xiong, Li Tao, Ke Xu, Jing Wang, Ying Guo, Jing Xu, Xin Yang, Na Wang & hellip; Tags: Research Source Type: research
Imaging features and clinical value of 18F-FDG PET/CT for predicting airway involvement in patients with relapsing polychondritis
This study ai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 14, 2023 Category: Rheumatology Authors: Jing-Wei Yi, Jun-Feng Huang, Peng Hou, Zi-Kai Lin, Jin-Sheng Lin, Si-Yan Lin, Min Wang, Shi-Yue Li and Xin-Lu Wang Tags: Research Source Type: research
Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes
Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) b... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2023 Category: Rheumatology Authors: Yu-Hsiu Chen, Xin Zhang, David Attarian and Virginia Byers Kraus Tags: Research Source Type: research
Upadacitinib effectiveness and factors associated with minimal disease activity achievement in patients with psoriatic arthritis: preliminary data of a real-life multicenter study
Upadacitinib (UPA) is a selective JAK inhibitor recently approved for the treatment of psoriatic arthritis (PsA). In this post-approval study, we aimed to evaluate the effectiveness and safety of UPA over 24 w... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 11, 2023 Category: Rheumatology Authors: Michele Maria Luchetti Gentiloni, Valentino Paci, Antonio Carletto, Alen Zabotti, Roberta Ramonda, Maria Sole Chimenti, Lorenzo Dagna, Nicoletta Luciano, Anna Piccinelli, Ivan Giovannini, Giovanni Striani, Nicola Boffini, Gilda Sandri, Niccol ò Possemato Tags: Research Source Type: research
Association of anti- β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases
This study aimed to reveal the association bet... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 6, 2023 Category: Rheumatology Authors: Katsuhiko Yoneda, Yo Ueda, Kenji Tanimura, Hisashi Arase, Hideto Yamada and Jun Saegusa Tags: Research Source Type: research
Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression
Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 5, 2023 Category: Rheumatology Authors: Lorena Rodriguez-Martinez, Cristina Garc ía-Moreno, Eva Perez-Pampin, María J. Gómara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golán, José A. Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro and Antonio González Tags: Research Source Type: research
The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint pain and swelling, synovial hyperplasia, cartilage damage, and bone destruction. The mechanisms of dendritic cell (DC) and T c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 5, 2023 Category: Rheumatology Authors: Zhandong Wang, Jinlong Zhang, Fangyu An, Jie Zhang, Xiangrui Meng, Shiqing Liu, Ruoliu Xia, Gang Wang and Chunlu Yan Tags: Review Source Type: research
