Low-dose xenogeneic mesenchymal stem cells target canine osteoarthritis through systemic immunomodulation and homing
As current therapies for canine osteoarthritis (OA) provide mainly symptomatic improvement and fail to address the complex pathology of the disease, mesenchymal stem cells (MSCs) offer a promising biological a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 3, 2023 Category: Rheumatology Authors: Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Lore Van Hecke, Koen Chiers, Leen Van Brantegem, Gabriele Braun, Klaus Hellmann, Nathalie de Bouvre, Nathalie Van Bruaene, Tine De Ryck, Luc Duchateau, Bernadette Van Ryssen, Kathelijne Peremans Tags: Research Source Type: research
Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitis
Primary biliary cholangitis (PBC) is an autoimmune liver disease, whose etiology is yet to be fully elucidated. Currently, ursodeoxycholic acid (UDCA) is the only first-line drug. However, 40% of PBC patients ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Siyuan Tian, Yinan Hu, Miao Zhang, Kemei Wang, Guanya Guo, Bo Li, Yulong Shang and Ying Han Tags: Research Source Type: research
Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic synovitis and bone destruction. Proinflammatory cytokines activate pathways of immune-mediated inflammation, which aggravates RA. Th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Fen Zhang, Ting Cheng and Sheng-Xiao Zhang Tags: Review Source Type: research
Hepatorenal pathologies in TNF-transgenic mouse model of rheumatoid arthritis are alleviated by anti-TNF treatment
To examine and quantify liver and kidney lesions and their response to anti-tumor necrosis factor (TNF) therapy in a TNF-Tg mouse model of rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Xuefei Li, Yi Wang, Ziqiang Chen, Ming Ruan, Can Yang, Maolin Zhou, Ning Li, Lianping Xing, Hao Xu, Ling Yang, Qi Shi, Yongjun Wang, Jinman Chen and Qianqian Liang Tags: Research Source Type: research
M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics
N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 2, 2023 Category: Rheumatology Authors: Yurong Huang, Qiuyun Xue, Jun Chang, Yuting Wang, Chenglong Cheng, Suowen Xu, Xiao Wang and Chenggui Miao Tags: Review Source Type: research
Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 29, 2023 Category: Rheumatology Authors: Youyou Zhang, Xiaoxi Li, Yining Wang, Liru Ge, Faming Pan, Tania Winzenberg and Guoqi Cai Tags: Research Source Type: research
Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start
Rheumatoid arthritis (RA) has a variable impact on different synovial joints, with inflammation being more commonly observed in some joints than others. Emerging evidence suggests that the anatomical variation... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 29, 2023 Category: Rheumatology Authors: Adrian Ciurea, Oliver Distler, Kenneth Kwok, Hyejin Jo, Lisy Wang, Tim Killeen, Caroline Ospelt and Mojca Frank Bertoncelj Tags: Research Source Type: research
Effectiveness of a treat-to-target strategy in patients with moderate to severely active rheumatoid arthritis treated with abatacept
To compare a treat-to-target (T2T) approach and routine care (RC) in adults with active to severely active rheumatoid arthritis (RA) initiating subcutaneous abatacept. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 28, 2023 Category: Rheumatology Authors: Louis Bessette, Boulos Haraoui, Emmanouil Rampakakis, Joanna Dembowy, Marc-Olivier Tr épanier and Janet Pope Tags: Research Source Type: research
Physical function and sex differences in radiographic axial spondyloarthritis: a cross-sectional analysis on Bath Ankylosing Spondylitis Functional Index
Physical function is an important determinant of health-related quality of life in radiographic axial spondyloarthritis patients (r-axSpA). To improve the basis of effective healthcare efforts, we aimed to inv... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 26, 2023 Category: Rheumatology Authors: Magnus Hallstr öm, Eva Klingberg, Anna Deminger, Jeannette Beckman Rehnman, Mats Geijer and Helena Forsblad-d’Elia Tags: Research Source Type: research
Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis
Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environm... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 25, 2023 Category: Rheumatology Authors: Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren and Zhihong Li Tags: Research Source Type: research
MyD88 dimerization inhibitor ST2825 targets the aggressiveness of synovial fibroblasts in rheumatoid arthritis patients
Dimerization of the myeloid differentiation primary response 88 protein (MyD88) plays a pivotal role in the exacerbated response to innate immunity-dependent signaling in rheumatoid arthritis (RA). ST2825 is a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 25, 2023 Category: Rheumatology Authors: Sergio Ramirez-Perez, Rushi Vekariya, Surabhi Gautam, Itzel Viridiana Reyes-Perez, Hicham Drissi and Pallavi Bhattaram Tags: Research Source Type: research
Automatic evaluation of atlantoaxial subluxation in rheumatoid arthritis by a deep learning model
This work aims to develop a deep learning model, assessing atlantoaxial subluxation (AAS) in rheumatoid arthritis (RA), which can often be ambiguous in clinical practice. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 25, 2023 Category: Rheumatology Authors: Yasutaka Okita, Toru Hirano, Bowen Wang, Yuta Nakashima, Saki Minoda, Hajime Nagahara and Atsushi Kumanogoh Tags: Research article Source Type: research
Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years
This study aimed to investigate the long-term effect of vitamin D supplementation compared to placebo over 5 years in participants with knee osteoarthritis (OA). We also aimed to describe the effect of maintai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 23, 2023 Category: Rheumatology Authors: Zhiqiang Wang, Zhaohua Zhu, Feng Pan, Shuang Zheng, Venkat Parameswaran, Leigh Blizzard, Changhai Ding and Benny Antony Tags: Research Source Type: research
Influence of the timing of biological treatment initiation on Juvenile Idiopathic Arthritis long-term outcomes
Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. However, it is unclear what is the long-term impact on health-related outcomes of the t... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 21, 2023 Category: Rheumatology Authors: Filipa Oliveira Ramos, Ana Maria Rodrigues, Ana Teresa Melo, Francisca Aguiar, Lu Ãsa Brites, Soraia Azevedo, Ana Catarina Duarte, José António Melo Gomes, Carolina Furtado, Ana Filipa Mourão, Graça Sequeira, Inês Cunha, Ricardo Figueira, Maria Josà Tags: Research Source Type: research
Identification of potential susceptibility genes in patients with primary Sj ögren’s syndrome-associated pulmonary arterial hypertension through whole exome sequencing
Pulmonary arterial hypertension (PAH) is a rare complication of primary Sj ögren’s syndrome (pSS). Several genes have proven to be associated with pSS and PAH. However, there is no study specifically addressing... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 20, 2023 Category: Rheumatology Authors: Mucong Li, Yue Shi, Jiuliang Zhao, Qian Wang, Mengtao Li and Xiuli Zhao Tags: Research Source Type: research
