Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
An increased risk of pregnancy complications is seen in women with systemic lupus erythematosus (SLE), but the specific immunopathological drivers are still unclear. Hallmarks of SLE are granulocyte activation... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2023 Category: Rheumatology Authors: Agnes Torell, Marit Stockfelt, Gunilla Larsson, Kaj Blennow, Henrik Zetterberg, Dag Leonard, Lars R önnblom, Muna Saleh, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A. Bengtsson, Estelle Trysberg, Maria Majcuk Sennström, Agneta Zicker Tags: Research Source Type: research
The regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis
This study aimed to elucidate the role of TUG1 in osteoarthritic cartilage damage and the underlying mechanisms. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 20, 2023 Category: Rheumatology Authors: Nan-nan Liu, Yan-ping Huang, Yu-bao Shao, Xue-fei Fan, He-yan Sun, Tao-rong Wang, Tao Yao and Xiao-Yu Chen Tags: Research Source Type: research
Characterization of miR-335-5p and miR-335-3p in human osteoarthritic tissues
We aimed to characterize the expression patterns, gene targets, and functional effects of miR-335-5p and miR-335-3p among seven primary human knee and hip osteoarthritic tissue types. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 16, 2023 Category: Rheumatology Authors: Thomas G. Wilson, Madhu Baghel, Navdeep Kaur, Vasilios Moutzouros, Jason Davis and Shabana Amanda Ali Tags: Research Source Type: research
B cell subsets in adult-onset Still ’s disease: potential candidates for disease pathogenesis and immunophenotyping
Adult-onset Still ’s disease (AOSD) is a systemic autoinflammatory disorder of unknown etiology. B cells are critical participants in different rheumatic diseases, and their roles in AOSD are rarely investigate... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2023 Category: Rheumatology Authors: Xiangyu Fang, Hua Ye, Yang Xie, Chaonan Wei, Shuyan Liu, Haihong Yao, Zhanguo Li, Yuan Jia and Fanlei Hu Tags: Research Source Type: research
Safety outcomes in patients with rheumatoid arthritis treated with abatacept: results from a multinational surveillance study across seven European registries
Patients with rheumatoid arthritis (RA) have an increased risk of infection and malignancy compared with the general population. Infection risk is increased further with the use of disease-modifying antirheuma... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 12, 2023 Category: Rheumatology Authors: Alyssa Dominique, Merete Lund Hetland, Axel Finckh, Jacques-Eric Gottenberg, Florenzo Iannone, Roberto Caporali, Tzuyung Douglas Kou, Dan Nordstrom, Maria Victoria Hernandez, Carlos S ánchez-Piedra, Fernando Sánchez-Alonso, Karel Pavelka, T. Christopher Tags: Research Source Type: research
Characterization of aberrant glycosylation associated with osteoarthritis based on integrated glycomics methods
Osteoarthritis (OA) is the most common form of arthritis, affecting millions of aging people. Investigation of abnormal glycosylation is essential for the understanding of pathological mechanisms of OA. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 12, 2023 Category: Rheumatology Authors: Hanjie Yu, Mingxiu Li, Jian Shu, Liuyi Dang, Xin Wu, Yuzi Wang, Xuan Wang, Xin Chang, Xiaojuan Bao, Bojing Zhu, Xiameng Ren, Wentian Chen and Yi Li Tags: Research Source Type: research
Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score
Polygenic risk score (PRS) analysis is used to predict disease risk. Although PRS has been shown to have great potential in improving clinical care, PRS accuracy assessment has been mainly focused on European ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 12, 2023 Category: Rheumatology Authors: Yugo Morita, Yoichiro Kamatani, Hiromu Ito, Shiro Ikegawa, Takahisa Kawaguchi, Shuji Kawaguchi, Meiko Takahashi, Chikashi Terao, Shuji Ito, Kohei Nishitani, Shinichiro Nakamura, Shinichi Kuriyama, Yasuharu Tabara, Fumihiko Matsuda and Shuichi Matsuda Tags: Research Source Type: research
Response to treatment in psoriatic arthritis, the effect of age: analysis of patients receiving ustekinumab in the PsABio real-world study
This post-hoc analysis of PsABio (NCT02627768) evaluated safety, effectiveness and treatment persistence in patients (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 9, 2023 Category: Rheumatology Authors: Laure Gossec, Elke Theander, Soumya D. Chakravarty, Paul Bergmans, Frederic Lavie, Wim No ël, Mohamed Sharaf, Stefan Siebert and Josef S. Smolen Tags: Research Source Type: research
Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data
In axial spondyloarthritis (axSpA), peripheral SpA (pSpA) and psoriatic arthritis (PsA), enthesitis is a hallmark clinical feature that can be assessed by the SPARCC index, LEI, MASES and MEI. These indices ev... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2023 Category: Rheumatology Authors: Raquel Ena Mar ía Granados, M. Lourdes Ladehesa-Pineda, M. Ángeles Puche-Larrubia, Alejandro Escudero-Contreras, Maxime Dougados, Eduardo Collantes-Estevez and Clementina López-Medina Tags: Research Source Type: research
Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation
High-temperature requirement serine protease A 2 (HtrA2) is known to be involved in growth, unfolded protein response to stress, apoptosis, and autophagy. However, whether HtrA2 controls inflammation and immun... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2023 Category: Rheumatology Authors: Gi Heon Jeong, Min-Kyung Nam, Wonhee Hur, Seolhee Heo, Saseong Lee, Eunbyeol Choi, Jae Hyung Park, Youngjae Park, Wan-Uk Kim, Hyangshuk Rhim and Seung-Ah Yoo Tags: Research Source Type: research
Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis
Lymphocyte activation gene-3 (LAG-3) inhibits T cell activation and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we st... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2023 Category: Rheumatology Authors: Janni Maria Pedersen, Aida Solh øj Hansen, Cæcilie Skejø, Kristian Juul-Madsen, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Bjarne Kuno Møller, Lene Dreyer, Ellen-Margrethe Hauge, Malene H Tags: Research Source Type: research
Sex and age do not modify the association between glucocorticoids and bone mineral density in patients with rheumatoid arthritis: a cross-sectional study
It is unclear whether sex or age modify the association of glucocorticoid (GC) use with reduced bone mineral density (BMD) in patients with rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2023 Category: Rheumatology Authors: Andriko Palmowski, Zhivana Boyadzhieva, Sabrina M. Nielsen, Burkhard Muche, Sandra Hermann, Maarten Boers, Henning Bliddal, Robin Christensen, Edgar Wiebe and Frank Buttgereit Tags: Research Source Type: research
Examining the influence of pain neuroscience education followed by a Pilates exercises program in individuals with knee osteoarthritis: a pilot randomized controlled trial
Knee osteoarthritis (OA) is a multifactorial form of rheumatic condition contributing to physical and psychological factors. Treatments have been provided solely and often compared with each other. An alternat... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2023 Category: Rheumatology Authors: Pouya Rabiei, Bahram Sheikhi and Amir Letafatkar Tags: Research Source Type: research
Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis
Intestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with spondyloarthritis but the time at which they appear and their contributi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2023 Category: Rheumatology Authors: Sophie Hecquet, Perle Totoson, H élène Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoît Valot, Didier Hocquet, Maude Tournier, Clément Prati, Daniel Wendling, Céline Demougeot and Frank Verhoeven Tags: Research Source Type: research
Utilizing biologic disease-modifying anti-rheumatic treatment sequences to subphenotype rheumatoid arthritis
Many patients with rheumatoid arthritis (RA) require a trial of multiple biologic disease-modifying anti-rheumatic drugs (bDMARDs) to control their disease. With the availability of several bDMARD options, the... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2023 Category: Rheumatology Authors: Priyam Das, Dana Weisenfeld, Kumar Dahal, Debsurya De, Vivi Feathers, Jonathan S. Coblyn, Michael E. Weinblatt, Nancy A. Shadick, Tianxi Cai and Katherine P. Liao Tags: Research Source Type: research
