Utilizing biologic disease-modifying anti-rheumatic treatment sequences to subphenotype rheumatoid arthritis
Many patients with rheumatoid arthritis (RA) require a trial of multiple biologic disease-modifying anti-rheumatic drugs (bDMARDs) to control their disease. With the availability of several bDMARD options, the... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2023 Category: Rheumatology Authors: Priyam Das, Dana Weisenfeld, Kumar Dahal, Debsurya De, Vivi Feathers, Jonathan S. Coblyn, Michael E. Weinblatt, Nancy A. Shadick, Tianxi Cai and Katherine P. Liao Tags: Research Source Type: research
Real-life drug retention rate and safety of rituximab when treating rheumatic diseases: a single-centre Swiss retrospective cohort study
In Switzerland, rituximab (RTX) is licenced for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV) but is frequently used off-label to treat other auto-immune diseases (AID), espec... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2023 Category: Rheumatology Authors: Alexandre Dumusc, Fahad Alromaih, Matthieu Perreau, Thomas H ügle, Pascal Zufferey and Diana Dan Tags: Research Source Type: research
Identification of the immune-related biomarkers in Behcet ’s disease by plasma proteomic analysis
This study aimed to investigate the expression profile of immune response-related proteins of Behcet ’s disease (BD) patients and identify potential biomarkers for this disease. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2023 Category: Rheumatology Authors: Huan Liu, Panpan Zhang, Fuzhen Li, Xiao Xiao, Yinan Zhang, Na Li, Liping Du and Peizeng Yang Tags: Research Source Type: research
Correction: Brain morphometric changes in fibromyalgia and the impact of psychometric and clinical factors: a volumetric and diffusion ‑tensor imaging study
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2023 Category: Rheumatology Authors: Benjamin Mosch, Verena Hagena, Stephan Herpertz and Martin Diers Tags: Correction Source Type: research
STING mediates experimental osteoarthritis and mechanical allodynia in mouse
This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2023 Category: Rheumatology Authors: Youngnim Shin, Deborah Cho, Seul Ki Kim and Jang-Soo Chun Tags: Research Source Type: research
Association of hemoglobin levels with radiographic progression in patients with rheumatoid arthritis: an analysis from the BRASS registry
To evaluate baseline hemoglobin (Hb) and radiographic progression over time in patients enrolled in the Brigham and Women ’s Rheumatoid Arthritis Sequential Study (BRASS) registry. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 27, 2023 Category: Rheumatology Authors: Nancy Shadick, Owen Hagino, Amy Praestgaard, Stefano Fiore, Michael Weinblatt and Gerd Burmester Tags: Research Source Type: research
Dopamine D2 receptor on CD4+ T cells is protective against inflammatory responses and signs in a mouse model of rheumatoid arthritis
Dopamine is a neurotransmitter and has been found to regulate lymphocytes by acting on dopamine receptors (DRs). CD4+ T cells express all the five subtypes of DRs, D1R to D5R. Although CD4+ T cells have been invo... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 26, 2023 Category: Rheumatology Authors: Xiao-Qin Wang, Huan-Huan Cai, Qiao-Wen Deng, Ya-Zhou Chang, Yu-Ping Peng and Yi-Hua Qiu Tags: Research Source Type: research
Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthr... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 22, 2023 Category: Rheumatology Authors: Marta Valero, Carlos S ánchez-Piedra, Mercedes Freire, María Colazo, Noemí Busquets, Erardo Meriño-Ibarra, Carlos Rodríguez-Lozano, Sara Manrique, Cristina Campos, Fernando Sánchez-Alonso and Isabel Castrejón Tags: Research Source Type: research
Characteristics of ScleroID highlighting musculoskeletal and internal organ implications in patients afflicted with systemic sclerosis
Systemic sclerosis (SSc) is a multi-organ disease with impaired health-related quality of life (HRQoL). The EULAR SSc Impact of Disease (ScleroID) is a newly introduced SSc-specific patient-reported outcome to... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 20, 2023 Category: Rheumatology Authors: Gabriella Nagy, Rucsandra Dobrota, Mike Oliver Becker, T ünde Minier, Cecília Varjú, Gábor Kumánovics, Oliver Distler and László Czirják Tags: Research Source Type: research
Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case –control study
Insulin resistance affects a substantial proportion of patients with rheumatoid arthritis (RA). Skeletal muscle mitochondrial dysfunction results in the accumulation of lipid intermediates that interfere with ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 20, 2023 Category: Rheumatology Authors: Douglas R. Moellering, Kelley Smith-Johnston, Christian Kelley, Melissa J. Sammy, Jason Benedict, Guy Brock, Jillian Johnson, Kedryn K. Baskin, Wael N. Jarjour, Martha A. Belury, Peter J. Reiser, Prabhakara R. Nagareddy and Beatriz Y. Hanaoka Tags: Research Source Type: research
Brain morphometric changes in fibromyalgia and the impact of psychometric and clinical factors: a volumetric and diffusion-tensor imaging study
Previous studies have repeatedly found distinct brain morphometric changes in patients with fibromyalgia (FM), mainly affecting gray and white matter abnormalities in areas related to sensory and affective pai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 19, 2023 Category: Rheumatology Authors: Benjamin Mosch, Verena Hagena, Stephan Herpertz and Martin Diers Tags: Research Source Type: research
Comparison of two doses of leucovorin in severe low-dose methotrexate toxicity – a randomized controlled trial
Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with low-dose methotrexate, but its optimum dose is unclear, varying from 15 to 25 mg every 6-h. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 19, 2023 Category: Rheumatology Authors: Mudit Bhargava, Chirag Rajkumar Kopp, Shankar Naidu, Deba Prasad Dhibar, Atul Saroch, Alka Khadwal, Tarun Narang, Siddharth Jain, Aastha Khullar, Bidya Leishangthem, Aman Sharma, Susheel Kumar, Shefali Sharma, Sanjay Jain and Varun Dhir Tags: Research Source Type: research
Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues
Investigation of cartilage and chondrocytes has revealed that the osteoarthritis risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their effects by decreasing the methylation status... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 19, 2023 Category: Rheumatology Authors: Yulia S. Kehayova, J. Mark Wilkinson, Sarah J. Rice and John Loughlin Tags: Research Source Type: research
Two-year imaging outcomes from a phase 3 randomized trial of secukinumab in patients with non-radiographic axial spondyloarthritis
Radiographic progression and course of inflammation over 2 years in patients with non-radiographic axial spondyloarthritis (nr-axSpA) from the phase 3, randomized, PREVENT study are reported here. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 16, 2023 Category: Rheumatology Authors: Juergen Braun, Ricardo Blanco, Helena Marzo-Ortega, Lianne S. Gensler, Filip Van den Bosch, Stephen Hall, Hideto Kameda, Denis Poddubnyy, Marleen van de Sande, D ésirée van der Heijde, Tingting Zhuang, Anna Stefanska, Aimee Readie, Hanno B. Richards and Tags: Research Source Type: research
Serum vitamin D levels and Sjogren ’s syndrome: bi-directional Mendelian randomization analysis
Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren ’s syndrome (SS) in humans is still controversial. Based on th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 15, 2023 Category: Rheumatology Authors: Meng Zhao, Feiran Wei, Han Li, Zemin Wang, Shuai Wang, Yangyang Liu, Gaoqiang Fei, You Ge and Pingmin Wei Tags: Research Source Type: research
