Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation
The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. Lung inflammation with resultant protein citrullination may trigger anti-citrullinated protein antibodies, inf... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 22, 2016 Category: Rheumatology Authors: Mandar Bawadekar, Annette Gendron-Fitzpatrick, Ryan Rebernick, Daeun Shim, Thomas F. Warner, Anthony P. Nicholas, Lennart K. A. Lundblad, Paul R. Thompson and Miriam A. Shelef Source Type: research

Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study
According to EULAR recommendations, biologic DMARDs (bDMARDs) such as tumor necrosis factor inhibitor, tocilizumab (TCZ), and abatacept (ABT) are in parallel when prescribing to rheumatoid arthritis (RA) patie... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 19, 2016 Category: Rheumatology Authors: Seiji Nakamura, Katsuya Suzuki, Hiroshi Iijima, Yuko Hata, Chun Ren Lim, Yohei Ishizawa, Hideto Kameda, Koichi Amano, Kenichi Matsubara, Ryo Matoba and Tsutomu Takeuchi Source Type: research

The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target
The unfolded protein response (UPR) is activated following an endoplasmic reticulum (ER) stress. The aim of this study was to investigate the global expression of UPR genes in human OA chondrocytes in induced ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 19, 2016 Category: Rheumatology Authors: Ying-Hua Li, Ginette Tardif, David Hum, Mohit Kapoor, Hassan Fahmi, Jean-Pierre Pelletier and Johanne Martel-Pelletier Source Type: research

Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus
The formation of destructive hypercellular pannus is critical to joint damage in rheumatoid arthritis (RA). The collagen triple helix repeat containing 1 (CTHRC1) protein expressed by activated stromal cells o... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 19, 2016 Category: Rheumatology Authors: Mohammed Talha Shekhani, Toni S. Forde, Altynai Adilbayeva, Mohamed Ramez, Askhat Myngbay, Yergali Bexeitov, Volkhard Lindner and Vyacheslav A. Adarichev Source Type: research

Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis
Inhomogeneity of immune cell distribution in the synovial sublining layer was analyzed in order to improve our mechanistic understanding of synovial inflammation and explore potential refinements for histologi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 16, 2016 Category: Rheumatology Authors: Johanna Mucke, Annika Hoyer, Ralph Brinks, Ellen Bleck, Thomas Pauly, Matthias Schneider and Stefan Vordenbäumen Source Type: research

The role of mitochondria in immune-mediated disease: the dangers of a split personality
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 16, 2016 Category: Rheumatology Authors: David S. Pisetsky Source Type: research

Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus
Recent achievement in genetics and epigenetics has led to the exploration of the pathogenesis of systemic lupus erythematosus (SLE). Identification of differentially expressed genes and their regulatory mechan... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2016 Category: Rheumatology Authors: Honglin Zhu, Wentao Mi, Hui Luo, Tao Chen, Shengxi Liu, Indu Raman, Xiaoxia Zuo and Quan-Zhen Li Source Type: research

Bone marrow contribution to synovial hyperplasia following joint surface injury
Joint surface injury, a known risk factor for osteoarthritis, triggers synovial hyperplasia, which involves proliferation of mesenchymal stromal/stem cells (MSCs). Whether these proliferative MSCs are resident... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2016 Category: Rheumatology Authors: Ana Sergijenko, Anke J. Roelofs, Anna H. K. Riemen and Cosimo De Bari Source Type: research

The type I interferon signature in leukocyte subsets from peripheral blood of patients with early arthritis: a major contribution by granulocytes
The type I interferon (IFN) signature in rheumatoid arthritis (RA) has shown clinical relevance in relation to disease onset and therapeutic response. Identification of the cell type(s) contributing to this IF... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2016 Category: Rheumatology Authors: Tamarah D. de Jong, Joyce Lübbers, Samina Turk, Saskia Vosslamber, Elise Mantel, Hetty J. Bontkes, Conny J. van der Laken, Johannes W. Bijlsma, Dirkjan van Schaardenburg and Cornelis L. Verweij Source Type: research

Incidence and prevalence of gout in Western Sweden
The aim of the present study was to describe prevalence and trends in the incidence of gout and patterns of urate-lowering treatment (ULT) in the Western Swedish Health Care Region (WSHCR) from 2002 to 2012. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2016 Category: Rheumatology Authors: Mats Dehlin, Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd and Lennart T. H. Jacobsson Source Type: research

Long-term outcome of patients with ANCA-associated vasculitis treated with plasma exchange: a retrospective, single-centre study
Plasma exchange (PLEX) has been used routinely for treatment of severe renal vasculitis and/or alveolar haemorrhage (AH) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but the long... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2016 Category: Rheumatology Authors: Doubravka Frausová, Zdenka Hrušková, Věra Lánská, Jana Lachmanová and Vladimír Tesař Source Type: research

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice
It has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic basis of this association is incompletely u... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 12, 2016 Category: Rheumatology Authors: Sasanka Chukkapalli, Mercedes Rivera-Kweh, Prashasnika Gehlot, Irina Velsko, Indraneel Bhattacharyya, S. John Calise, Minoru Satoh, Edward K. L. Chan, Joseph Holoshitz and Lakshmyya Kesavalu Source Type: research

Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity
Serum levels of calprotectin, a major S100 leucocyte protein, are associated with disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients. Higher drug trough serum levels are assoc... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 8, 2016 Category: Rheumatology Authors: José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete and Raimon Sanmarti Source Type: research

Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies
The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies.... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 7, 2016 Category: Rheumatology Authors: Joanna E. Parkes, Simon Rothwell, Philip J. Day, Neil J. McHugh, Zoë E. Betteridge, Robert G. Cooper, William E. Ollier, Hector Chinoy and Janine A. Lamb Source Type: research

Whole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis
The Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (TREAT trial) was accompanied by a once-in-a-generation sample collection for translational research. In this paper, we report the results... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 7, 2016 Category: Rheumatology Authors: Kaiyu Jiang, Laiping Wong, Ashley D. Sawle, M. Barton Frank, Yanmin Chen, Carol A. Wallace and James N. Jarvis Source Type: research

H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis
Epigenetic changes (i.e., chromatin modifications) occur during chondrogenesis and in osteoarthritis (OA). We investigated the effect of H3K27me3 demethylase inhibition on chondrogenesis and assessed its utili... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 7, 2016 Category: Rheumatology Authors: Clarence Yapp, Andrew J. Carr, Andrew Price, Udo Oppermann and Sarah J. B. Snelling Source Type: research

miR-155 in the progression of lung fibrosis in systemic sclerosis
MicroRNA (miRNA) control key elements of mRNA stability and likely contribute to the dysregulated lung gene expression observed in systemic sclerosis associated interstitial lung disease (SSc-ILD). We analyzed... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2016 Category: Rheumatology Authors: Romy B. Christmann, Alicia Wooten, Percival Sampaio-Barros, Claudia L. Borges, Carlos R. R. Carvalho, Ronaldo A. Kairalla, Carol Feghali-Bostwick, Jessica Ziemek, Yu Mei, Salma Goummih, Jiangning Tan, Diana Alvarez, Daniel J. Kass, Mauricio Rojas, Thiago Source Type: research

Erratum to: The prevalence and clinical characteristics of nonradiographic axial spondyloarthritis among patients with inflammatory back pain in rheumatology practices: a multinational, multicenter study
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 4, 2016 Category: Rheumatology Authors: Ruben Burgos-Vargas, James Cheng-Chung Wei, Mahboob U. Rahman, Nurullah Akkoc, Syed Atiqul Haq, Mohammed Hammoudeh, Ehab Mahgoub, Ena Singh, Lyndon John Llamado, Khalid Shirazy, Sameer Kotak, Constance Hammond, Ron Pedersen, Qi Shen and Bonnie Vlahos Source Type: research

Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review
Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in p... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 2, 2016 Category: Rheumatology Authors: Rui Baptista, Sara Serra, Rui Martins, Rogério Teixeira, Graça Castro, Maria João Salvador, José António Pereira da Silva, Lèlita Santos, Pedro Monteiro and Mariano Pêgo Source Type: research

Erratum to: JAK3-STAT pathway blocking benefits in experimental lupus nephritis
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 1, 2016 Category: Rheumatology Authors: Èlia Ripoll, Laura de Ramon, Juliana Draibe, Ana Merino, Nuria Bolaños, Montse Goma, Josep M. Cruzado, Josep M. Grinyó and Juan Torras Source Type: research

Are estrogen-related drugs new alternatives for the management of osteoarthritis?
Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues su... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 28, 2016 Category: Rheumatology Authors: Ya-Ping Xiao, Fa-Ming Tian, Mu-Wei Dai, Wen-Ya Wang, Li-Tao Shao and Liu Zhang Source Type: research

Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model
Lack of validity in osteoarthritis pain models and assessment methods is suspected. Our goal was to 1) assess the repeatability and reproducibility of measurement and the influence of environment, and acclimat... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2016 Category: Rheumatology Authors: Colombe Otis, Julie Gervais, Martin Guillot, Julie-Anne Gervais, Dominique Gauvin, Catherine Péthel, Simon Authier, Marc-André Dansereau, Philippe Sarret, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Francis Beaudry and Eric Troncy Source Type: research

Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion
During chronic inflammation, immune cells, notably Th17 cells, infiltrate the inflammatory site and interact with local mesenchymal cells. Applied to rheumatoid arthritis (RA), the aim is to study the interact... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2016 Category: Rheumatology Authors: Mélissa Noack, Ndiémé Ndongo-Thiam and Pierre Miossec Source Type: research

Endothelial progenitor cells are differentially impaired in ANCA-associated vasculitis compared to healthy controls
Endothelial progenitor cells (EPC) are of major importance in vascular repair under healthy circumstances. Vascular injury in need of repair occurs frequently in ANCA-associated vasculitis (AAV). A specialized... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2016 Category: Rheumatology Authors: B. Wilde, A. Mertens, S. J. Arends, R. P. Rouhl, R. Bijleveld, J. Huitema, S. A. Timmermans, J. Damoiseaux, O. Witzke, A. M. Duijvestijn, P. van Paassen, R. J. van Oostenbrugge and J. W. Cohen Tervaert Source Type: research

Body mass index distribution in rheumatoid arthritis: a collaborative analysis from three large German rheumatoid arthritis databases
The objective of this study was to compare the bod... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2016 Category: Rheumatology Authors: Katinka Albrecht, Adrian Richter, Johanna Callhoff, Dörte Huscher, Georg Schett, Anja Strangfeld and Angela Zink Source Type: research

Inflammatory conditions partly impair the mechanically mediated activation of Smad2/3 signaling in articular cartilage
Joint trauma, which is frequently related with mechanical overloading of articular cartilage, is a well-established risk for osteoarthritis (OA) development. Additionally, reports show that trauma leads to syn... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2016 Category: Rheumatology Authors: Wojciech Madej, Pieter Buma and Peter van der Kraan Source Type: research

Switching from adalimumab to tofacitinib in the treatment of patients with rheumatoid arthritis
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The aim of this study was to explore the safety and efficacy of open-label tofacitinib following blinded treatment ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2016 Category: Rheumatology Authors: Mark C. Genovese, Ronald F. van Vollenhoven, Bethanie Wilkinson, Lisy Wang, Samuel H. Zwillich, David Gruben, Pinaki Biswas, Richard Riese, Liza Takiya and Thomas V. Jones Source Type: research

Erratum to: Effectiveness of two different doses of rituximab for the treatment of rheumatoid arthritis in an international cohort: data from the CERERRA collaboration
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 20, 2016 Category: Rheumatology Authors: Katerina Chatzidionysiou, Elisabeth Lie, Evgeny Nasonov, Galina Lukina, Merete Lund Hetland, Ulrik Tarp, Ioan Ancuta, Karel Pavelka, Dan C. Nordström, Cem Gabay, Helene Canhão, Matija Tomsic, Piet L. C. M. van Riel, Juan Gomez-Reino, Tore K. Kvien and R Source Type: research

Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33
Interleukin (IL)-33 is a dual cytokine with both an alarmin role and a T helper 2 cell (Th2)-like inducing effect. It is involved in the pathogenesis of rheumatoid arthritis (RA) and its models; we recently de... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 18, 2016 Category: Rheumatology Authors: Sara Khaleghparast Athari, Elodie Poirier, Jérôme Biton, Luca Semerano, Roxane Hervé, Aurélie Raffaillac, Delphine Lemeiter, André Herbelin, Jean-Philippe Girard, Frédéric Caux, Marie-Christophe Boissier and Natacha Bessis Source Type: research

Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis
Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both are characterized by altered extracellular matrix remodeling in joints and e... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 16, 2016 Category: Rheumatology Authors: Natasja Stæhr Gudmann, Heidi Lausten Munk, Anne Friesgaard Christensen, Leif Ejstrup, Grith Lykke Sørensen, Anne Gitte Loft, Morten Asser Karsdal, Anne-Christine Bay-Jensen, Yi He, Anne Sofie Siebuhr and Peter Junker Source Type: research

Optimal responses in disease activity scores to treatment in rheumatoid arthritis: Is a DAS28 reduction of >1.2 sufficient?
The overall benefit of intensive treatment strategies in rheumatoid arthritis (RA) remains uncertain. We explored how reductions in disability and improvements in quality of life scores are affected by alterna... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 16, 2016 Category: Rheumatology Authors: Aneela N. Mian, Fowzia Ibrahim, David L. Scott and James Galloway Source Type: research

Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2016 Category: Rheumatology Authors: Sofia E. M. Andersson, Tove Eneljung, Sara Tengvall, Pernilla Jirholt, Anna Stern, Louise Henningsson, Bibo Liang, Katrin Thorarinsdottir, Jan Kihlberg, Rikard Holmdahl, Inga-Lill Mårtensson, Kenth Gustafsson and Inger Gjertsson Source Type: research

Nuclear factor erythroid 2-related factor 2 is a critical target for the treatment of glucocorticoid-resistant lupus nephritis
Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. The aim of this study is to evaluate the ant... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2016 Category: Rheumatology Authors: Shin Ebihara, Hideaki Tajima and Masao Ono Source Type: research

Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia
This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2016 Category: Rheumatology Authors: Malin Ernberg, Nikolaos Christidis, Bijar Ghafouri, Indre Bileviciute-Ljungar, Monika Löfgren, Anette Larsson, Annie Palstam, Jan Bjersing, Kaisa Mannerkorpi, Eva Kosek and Björn Gerdle Source Type: research

Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile
Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, which is characterized by inflammation of synovial joints leading to the destruction of cartilage and bone. Infiltrating mast cells can be foun... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2016 Category: Rheumatology Authors: Daniël van der Velden, H. Maxime Lagraauw, Anouk Wezel, Pierre Launay, Johan Kuiper, Tom W. J. Huizinga, René E. M. Toes, Ilze Bot and Jeroen N. Stoop Source Type: research

A five-year model to assess the early cost-effectiveness of new diagnostic tests in the early diagnosis of rheumatoid arthritis
There is a lack of information about the sensitivity, specificity and costs new diagnostic tests should have to improve early diagnosis of rheumatoid arthritis (RA). Our objective was to explore the early cost... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 10, 2016 Category: Rheumatology Authors: Leander R. Buisman, Jolanda J. Luime, Mark Oppe, Johanna M. W. Hazes and Maureen P. M. H. Rutten-van Mölken Source Type: research

Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents
Polymyositis (PM) and dermatomyositis (DM) are autoimmune muscle diseases, conventionally treated with high doses of glucocorticoids in combination with immunosuppressive drugs. Treatment is often dissatisfyin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 10, 2016 Category: Rheumatology Authors: Ingela Loell, Joan Raouf, Yi-Wen Chen, Rongye Shi, Inger Nennesmo, Helene Alexanderson, Maryam Dastmalchi, Kanneboyina Nagaraju, Marina Korotkova and Ingrid E. Lundberg Source Type: research

JAK3-STAT pathway blocking benefits in experimental lupus nephritis
Lupus nephritis (LN) is a complex chronic autoimmune disease of unknown etiology characterized by loss of tolerance against several self-antigens. Cytokines are known to be central players in LN pathogenesis. ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2016 Category: Rheumatology Authors: Èlia Ripoll, Laura de Ramon, Juliana Draibe Bordignon, Ana Merino, Nuria Bolaños, Montse Goma, Josep M. Cruzado, Josep M. Grinyó and Juan Torras Source Type: research

Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages
The aim of this study was to assess the effects of soluble sialic acid-binding immunoglobulin-type lectin (sSiglec)-9 on joint inflammation and destruction in a murine collagen-induced arthritis (CIA) model an... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2016 Category: Rheumatology Authors: Takuya Matsumoto, Nobunori Takahashi, Toshihisa Kojima, Yutaka Yoshioka, Jun Ishikawa, Koichi Furukawa, Kenji Ono, Makoto Sawada, Naoki Ishiguro and Akihito Yamamoto Source Type: research

The prevalence and clinical characteristics of nonradiographic axial spondyloarthritis among patients with inflammatory back pain in rheumatology practices: a multinational, multicenter study
Patients with ankylosing spondylitis (AS), who by definition have radiographic sacroiliitis, typically experience symptoms for a decade or more before being diagnosed. Yet, even patients without radiographic s... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2016 Category: Rheumatology Authors: Ruben Burgos-Varga, James Cheng-Chung Wei, Mahboob U. Rahman, Nurullah Akkoc, Syed Atiqul Haq, Mohammed Hammoudeh, Ehab Mahgoub, Ena Singh, Lyndon John Llamado, Khalid Shirazy, Sameer Kotak, Constance Hammond, Ron Pedersen, Qi Shen and Bonnie Vlahos Source Type: research

Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study
Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2016 Category: Rheumatology Authors: Elena Schiopu, Soumya Chatterjee, Vivien Hsu, Armando Flor, Daniel Cimbora, Kaushik Patra, Wenliang Yao, Jing Li, Katie Streicher, Kathleen McKeever, Barbara White, Eliezer Katz, Jorn Drappa, Sarah Sweeny and Ronald Herbst Source Type: research

The isotype repertoire of antibodies against novel UH-RA peptides in rheumatoid arthritis
Recently, autoantibodies against novel UH-RA peptides (UH-RA.1 and UH-RA.21) were identified as candidate biomarkers for patients with rheumatoid arthritis (RA) who are seronegative for the current diagnostic ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2016 Category: Rheumatology Authors: Liesbeth M. De Winter, Piet Geusens, Jan Lenaerts, Johan Vanhoof, Piet Stinissen and Veerle Somers Source Type: research

Exercise therapy after ultrasound-guided corticosteroid injections in patients with subacromial pain syndrome: a randomized controlled trial
Subacromial pain syndrome (SAPS) accounts for around 50 % of all cases of shoulder pain. The most commonly used treatments are glucocorticosteroid (steroid) injections and exercise therapy; however, despite tr... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 4, 2016 Category: Rheumatology Authors: Karen Ellegaard, Robin Christensen, Sara Rosager, Cecilie Bartholdy, Søren Torp-Pedersen, Thomas Bandholm, Bente Danneskiold-Samsøe, Henning Bliddal and Marius Henriksen Source Type: research

Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model
This study aimed to determine whether cu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 3, 2016 Category: Rheumatology Authors: Zhuo Zhang, Daniel J. Leong, Lin Xu, Zhiyong He, Angela Wang, Mahantesh Navati, Sun J. Kim, David M. Hirsh, John A. Hardin, Neil J. Cobelli, Joel M. Friedman and Hui B. Sun Source Type: research

Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis
Anti-citrullinated-peptide antibodies (ACPA) have been detected in individuals with developing rheumatoid arthritis (RA) before the onset of symptom, with an initially limited spectrum of reactivities that gra... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 3, 2016 Category: Rheumatology Authors: Linda Johansson, Federico Pratesi, Mikael Brink, Lisbeth Ärlestig, Claudia D’Amato, Debora Bartaloni, Paola Migliorini and Solbritt Rantapää-Dahlqvist Source Type: research

Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype
Notochordal cell conditioned medium (NCCM) derived from non-chondrodystrophic dogs has pro-anabolic and anti-catabolic effects upon nucleus pulposus (NP) cells. Here, for the first time, we assessed the abilit... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2016 Category: Rheumatology Authors: Sebastian Müller, Lina Acevedo, Xiaomei Wang, M. Zia Karim, Ajay Matta, Arne Mehrkens, Stefan Schaeren, Sandra Feliciano, Marcel Jakob, Ivan Martin, Andrea Barbero and W. Mark Erwin Source Type: research

Could we use a lower dose of rituximab to treat rheumatoid arthritis in clinical practice: pros and cons?
The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has be... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2016 Category: Rheumatology Authors: Gianfranco Ferraccioli, Barbara Tolusso and Elisa Gremese Source Type: research

MicroRNA-125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis
MicroRNAs (miRNAs) are small RNAs that regulate gene expression by targeting mRNA. It was proved that some miRNAs are significantly deregulated in rheumatoid arthritis (RA). MicroRNA-125b negatively regulates ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2016 Category: Rheumatology Authors: Veronika Hruskova, Romana Jandova, Lucia Vernerova, Herman Mann, Ondrej Pecha, Klara Prajzlerova, Karel Pavelka, Jiri Vencovsky, Maria Filkova and Ladislav Senolt Source Type: research

Cyclophosphamide versus mycophenolate mofetil in scleroderma interstitial lung disease (SSc-ILD) as induction therapy: a single-centre, retrospective analysis
Scleroderma is a systemic autoimmune disease characterized mainly by skin manifestations and involvement of various visceral organs, especially the lungs. Lung involvement is the leading cause of mortality in ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 2, 2016 Category: Rheumatology Authors: Padmanabha D. Shenoy, Manish Bavaliya, Sujith Sashidharan, Kaveri Nalianda and Sreelakshmi Sreenath Source Type: research

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2016 Category: Rheumatology Authors: Zoltán Pethő, Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S. Gulko and Christine Beeton Source Type: research