Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies
To classify the different clinical phenotypes and compare the distinct prognoses of microscopic polyangiitis (MPA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 7, 2023 Category: Rheumatology Authors: Juan Wang, Rui Li, Wenyan Zhou, Yanwei Lin, Xiaodong Wang, Shuang Ye, Liangjing Lu, Minfang Zhang and Sheng Chen Tags: Research Source Type: research
Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse
This study ai... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 6, 2023 Category: Rheumatology Authors: Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim and Jang-Soo Chun Tags: Research Source Type: research
Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 4, 2023 Category: Rheumatology Authors: Zhuolun Wang, Xinjie Wang, Liangliang Liu, Xiongtian Guo, Haiyan Zhang, Jianbing Yin, Rengui Lin, Yan Shao and Daozhang Cai Tags: Research Source Type: research
Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate diff... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 2, 2023 Category: Rheumatology Authors: Ale š Kvasnička, David Friedecký, Radana Brumarová, Markéta Pavlíková, Kateřina Pavelcová, Jana Mašínová, Lenka Hasíková, Jakub Závada, Karel Pavelka, Pavel Ješina and Blanka Stibůrková Tags: Research Source Type: research
Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes
Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in humans. Cur... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 1, 2023 Category: Rheumatology Authors: Jacob Kenny, Benjamin H. Mullin, William Tomlinson, Brett Robertson, Jinbo Yuan, Weiwei Chen, Jinmin Zhao, Nathan J. Pavlos, John P. Walsh, Scott G. Wilson, Jennifer Tickner, Grant Morahan and Jiake Xu Tags: Research Source Type: research
Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis
PANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune diseases. Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies. Ne... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - December 1, 2023 Category: Rheumatology Authors: Jing Li, Jun Cui, Li Wu, Ya-bing Liu and Qi Wang Tags: Research Source Type: research
The relation between synovitis of individual finger joints and grip force over the first 5 years in early rheumatoid arthritis — a cohort study
The objective of this study was to investigate the relation between swelling and tenderness of individual finger joints and grip force in patients with early rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 30, 2023 Category: Rheumatology Authors: Maria Rydholm, Ankita Sharma, Lennart Jacobsson and Carl Turesson Tags: Research Source Type: research
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation
Innate immunity plays a significant role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA), which is characterized by synovial inflammation and condylar cartilage degradation. We are urged ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 29, 2023 Category: Rheumatology Authors: Xin Liu, Huimin Li, Yaping Feng, Huilin Guo, Yingjie Li, Jin Ke and Xing Long Tags: Research Source Type: research
Long-term follow-up of children with chronic non-bacterial osteomyelitis —assessment of disease activity, risk factors, and outcome
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone-disease of unknown origin. The National Pediatric Rheumatologic Database (NPRD) collects long-term data of children and adolescents with rh... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 28, 2023 Category: Rheumatology Authors: Christiane Reiser, Jens Klotsche, Toni Hospach, Georg Heubner, Daniel Windschall, Ralf Trauzeddel, Nadine Groesch, Martina Niewerth, Kirsten Minden and Hermann Girschick Tags: Research Source Type: research
Characterization of human placenta-derived exosome (pExo) as a potential osteoarthritis disease modifying therapeutic
Human placenta-derived exosomes (pExo) were generated, characterized, and evaluated as a therapeutic candidate for the treatment of osteoarthritis (OA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 28, 2023 Category: Rheumatology Authors: Chenfei Huang, Yuechao Zhao, Shengchen Lin, Lin Li, Xuan Guo, Sebastian Yumiseba, Jeng-dar Yang, Robert Hariri, Qian Ye, Shuyang He and Adrian Kilcoyne Tags: Research Source Type: research
Impact of IL6R genetic variants on treatment efficacy and toxicity response to sarilumab in rheumatoid arthritis
Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors of response to sarilumab ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 24, 2023 Category: Rheumatology Authors: Luis Sainz, Pau Riera, Patricia Moya, Sara Bernal, Jordi Casademont, Cesar D íaz-Torné, Ana Milena Millán, Hye Sang Park, Adriana Lasa and Hector Corominas Tags: Research Source Type: research
Assessment of axial spondyloarthritis activity using a magnetic resonance imaging-based multi-region-of-interest fusion model
Identifying axial spondyloarthritis (axSpA) activity early and accurately is essential for treating physicians to adjust treatment plans and guide clinical decisions promptly. The current literature is mostly ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 24, 2023 Category: Rheumatology Authors: Peijin Xin, Qizheng Wang, Ruixin Yan, Yongye Chen, Yupeng Zhu, Enlong Zhang, Cui Ren and Ning Lang Tags: Research Source Type: research
Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach
Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have clustered them using machine learning (ML). We applied various ML algorithms to compare the clusters of comorbidi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 22, 2023 Category: Rheumatology Authors: Daniel H. Solomon, Hongshu Guan, Fredrik D. Johansson, Leah Santacroce, Wendi Malley, Lin Guo and Heather Litman Tags: Research Source Type: research
Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis
This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in relation to disea... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 22, 2023 Category: Rheumatology Authors: K Kielbassa, L Van der Weele, AE Voskuyl, N de Vries, E Eldering and TW Kuijpers Tags: Research Source Type: research
Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and scoping review
To determine the prevalence of sustained remission/low disease activity (LDA) in patients with rheumatoid arthritis (RA) after discontinuation of tumor necrosis factor inhibitors (TNFi), separately in inductio... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 20, 2023 Category: Rheumatology Authors: Michael M. Ward, Nima Madanchi, Ali Yazdanyar, Nehal R. Shah and Florina Constantinescu Tags: Research Source Type: research
