Serum levels of B-cell activating factor of the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis
B-cell activating factor of the tumour necrosis factor family (BAFF) plays a role in autoantibody production and is elevated in dermatomyositis (DM) and anti-Jo-1-positive polymyositis (PM). We investigated th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 27, 2018 Category: Rheumatology Authors: Olga Kry štůfková, Hana Hulejová, Heřman F. Mann, Ondřej Pecha, Ivana Půtová, Louise Ekholm, Ingrid E. Lundberg and Jiří Vencovský Tags: Research article Source Type: research

A randomized controlled trial comparing PF-06438179/GP1111 (an infliximab biosimilar) and infliximab reference product for treatment of moderate to severe active rheumatoid arthritis despite methotrexate therapy
This double-blind, active-controlled, randomized, multinational study evaluated the efficacy, safety, pharmacokinetics (PK), and immunogenicity of PF-06438179/GP1111 (IxifiTM/Zessly ®), an infliximab biosimilar... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 27, 2018 Category: Rheumatology Authors: Stanley B. Cohen, Rieke Alten, Hideto Kameda, Tomas Hala, Sebastiao C. Radominski, Muhammad I. Rehman, Ramesh Palaparthy, Karl Schumacher, Susanne Schmitt, Steven Y. Hua, Claudia Ianos and K. Lea Sewell Tags: Research article Source Type: research

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation
Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) o... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 20, 2018 Category: Rheumatology Authors: Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steink ühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten and Timothy R. D. J. Radstake Tags: Research article Source Type: research

Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients
It is not known if sex-based disparities in immunological factors contribute to the disease process in rheumatoid arthritis (RA). Hence, we examined whether circulating T cell subset proportions and their asso... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 20, 2018 Category: Rheumatology Authors: Jonathan Aldridge, Jayesh M. Pandya, Linda Meurs, Kerstin Andersson, Inger Nordstr öm, Elke Theander, Anna-Carin Lundell and Anna Rudin Tags: Research article Source Type: research

Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota
Dysbiosis occurs in spondyloarthritis (SpA) and inflammatory bowel disease (IBD), which is subdivided into Crohn ’s disease (CD) and ulcerative colitis (UC). The immunologic consequences of alterations in micro... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 20, 2018 Category: Rheumatology Authors: Emilie H. Regner, Neha Ohri, Andrew Stahly, Mark E. Gerich, Blair P. Fennimore, Diana Ir, Widian K. Jubair, Carsten G örg, Janet Siebert, Charles E. Robertson, Liron Caplan, Daniel N. Frank and Kristine A. Kuhn Tags: Research article Source Type: research

Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-na ïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study
Following the onset of rheumatoid arthritis (RA), patients experience a functional decline caused by various joint symptoms which affects their activities of daily living and can lead to reduced work productiv... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 20, 2018 Category: Rheumatology Authors: Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda and Hitoshi Kohsaka Tags: Research article Source Type: research

Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS)
Methotrexate (MTX) remains the disease-modifying anti-rheumatic drug of first choice in rheumatoid arthritis (RA) but response varies. Predicting non-response to MTX could enable earlier access to alternative ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2018 Category: Rheumatology Authors: Jamie C. Sergeant, Kimme L. Hyrich, James Anderson, Kamilla Kopec-Harding, Holly F. Hope, Deborah P. M. Symmons, Anne Barton and Suzanne M. M. Verstappen Tags: Research article Source Type: research

The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy
Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 13, 2018 Category: Rheumatology Authors: Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bj ørg-Tilde Svanes Fevang, Anca Irinel Catrina and Espen Andre Haavardsholm Tags: Research article Source Type: research

Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis
Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 11, 2018 Category: Rheumatology Authors: Oh Chan Kwon, Sang-Won Lee, Yong-Beom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo and Yong-Gil Kim Tags: Research article Source Type: research

miR-155 is dispensable in monosodium urate-induced gouty inflammation in mice
The findings of a previous study by Jin et al. have shown that microRNA (miR)-155 was upregulated in patients with acute gouty arthritis and enhanced the proinflammatory cytokines. There is no direct evidence ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 11, 2018 Category: Rheumatology Authors: Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi and Jingguo Zhou Tags: Research article Source Type: research

The prevalence of depression in axial spondyloarthritis and its association with disease activity: a systematic review and meta-analysis
Depression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axS... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 11, 2018 Category: Rheumatology Authors: Sizheng Zhao, Daniel Thong, Natasha Miller, Stephen J. Duffield, David M. Hughes, Laura Chadwick and Nicola J. Goodson Tags: Review Source Type: research

Gout prevalence and predictors of urate-lowering therapy use: results from a population-based study
Gout has an increasing global prevalence. Underutilization of urate-lowering therapy (ULT) is thought to be common, via both suboptimal dosing and poor medication adherence. The aims of this study were to dete... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 11, 2018 Category: Rheumatology Authors: Huai Leng Pisaniello, Susan Lester, David Gonzalez-Chica, Nigel Stocks, Marie Longo, Greg R. Sharplin, Eleonora Dal Grande, Tiffany K. Gill, Samuel L. Whittle and Catherine L. Hill Tags: Research article Source Type: research

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR- γ is the master regulator of adipogenesis. Peroxisome proliferator ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 11, 2018 Category: Rheumatology Authors: Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte and John Varga Tags: Research article Source Type: research

Next-generation sequencing profiling of mitochondrial genomes in gout
Accumulating evidence implicates mitochondrial DNA (mtDNA) alleles, which are independent of the nuclear genome, in disease, especially in human metabolic diseases. However, this area of investigation has lagg... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 6, 2018 Category: Rheumatology Authors: Chia-Chun Tseng, Chung-Jen Chen, Jeng-Hsien Yen, Hsi-Yuan Huang, Jan-Gowth Chang, Shun-Jen Chang and Wei-Ting Liao Tags: Research article Source Type: research

Hydroxychloroquine prescription trends and predictors for excess dosing per recent ophthalmology guidelines
Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2018 Category: Rheumatology Authors: April M. Jorge, Ronald B. Melles, Yuqing Zhang, Na Lu, Sharan K. Rai, Lucy H. Young, Karen H. Costenbader, Rosalind Ramsey-Goldman, S. Sam Lim, John M. Esdaile, Ann E. Clarke, M. B. Urowitz, Anca Askanase, Cynthia Aranow, Michelle Petri and Hyon Choi Tags: Research article Source Type: research

The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies
Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include the infiltration of inflammatory cells into muscle tissues. Neutrophil se... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2018 Category: Rheumatology Authors: Siming Gao, Xiaoxia Zuo, Di Liu, Yizhi Xiao, Honglin Zhu, Huali Zhang and Hui Luo Tags: Research article Source Type: research

Mediation analysis to understand genetic relationships between habitual coffee intake and gout
Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2018 Category: Rheumatology Authors: Joseph Hutton, Tahzeeb Fatima, Tanya J. Major, Ruth Topless, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth Tags: Research article Source Type: research

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies
Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hyperten... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2018 Category: Rheumatology Authors: Peter L. Evans, James A. Prior, John Belcher, Christian D. Mallen, Charles A. Hay and Edward Roddy Tags: Research article Source Type: research

Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients
Chemerin is a chemoattractant involved in immunity that also functions as an adipokine. Chemerin is secreted as an inactive precursor (chem163S), and its activation requires proteolytic cleavages at its C-term... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 4, 2018 Category: Rheumatology Authors: Lei Zhao, Yasuto Yamaguchi, Xiaomei Ge, William H. Robinson, John Morser and Lawrence L. K. Leung Tags: Research article Source Type: research

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo
Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms hav... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2018 Category: Rheumatology Authors: Catherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, C écile Lambert, Rose K. Davidson, Ian M. Clark, Paul J. Thornalley, Yves Henrotin and Naila Rabbani Tags: Research article Source Type: research

Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis
Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from pati... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 19, 2018 Category: Rheumatology Authors: Yu-Lan Chen, Jun Jing, Ying-Qian Mo, Jian-Da Ma, Li-Juan Yang, Le-Feng Chen, Xiang Zhang, Tao Yan, Dong-Hui Zheng, Frank Pessler and Lie Dai Tags: Research article Source Type: research

Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials
In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 19, 2018 Category: Rheumatology Authors: Yalong Di, Changxu Han, Liang Zhao and Yizhong Ren Tags: Research article Source Type: research

Patient-reported outcomes from a randomized phase III trial of sarilumab monotherapy versus adalimumab monotherapy in patients with rheumatoid arthritis
The phase III MONARCH randomized controlled trial (NCT02332590) demonstrated that in patients with rheumatoid arthritis (RA), sarilumab (anti-interleukin-6 receptor monoclonal antibody) monotherapy is superior... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 19, 2018 Category: Rheumatology Authors: Vibeke Strand, Laure Gossec, Clare W. J. Proudfoot, Chieh-I Chen, Matthew Reaney, Sophie Guillonneau, Toshio Kimura, Janet van Adelsberg, Yong Lin, Erin K. Mangan, Hubert van Hoogstraten and Gerd R. Burmester Tags: Research article Source Type: research

Anti-carbamylated protein antibodies as a new biomarker of erosive joint damage in systemic lupus erythematosus
The application of more sensitive imaging techniques, such as ultrasonography (US), changed the concept of non-erosive arthritis in systemic lupus erythematosus (SLE), underlining the need for biomarkers to id... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2018 Category: Rheumatology Authors: Fulvia Ceccarelli, Carlo Perricone, Tania Colasanti, Laura Massaro, Enrica Cipriano, Monica Pendolino, Francesco Natalucci, Riccardo Mancini, Francesca Romana Spinelli, Guido Valesini, Fabrizio Conti and Cristiano Alessandri Tags: Research article Source Type: research

Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and inc... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2018 Category: Rheumatology Authors: David B. Bartlett, Leslie H. Willis, Cris A. Slentz, Andrew Hoselton, Leslie Kelly, Janet L. Huebner, Virginia B. Kraus, Jennifer Moss, Michael J. Muehlbauer, Guillaume Spielmann, William E. Kraus, Janet M. Lord and Kim M. Huffman Tags: Research article Source Type: research

Correction to: Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis
Unfortunately, after publication of this article [1], it was noticed that the panel for Fig. 4b was inadvertently obscured during the production process. The full, correct Fig. 4 can be seen below and the orig... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2018 Category: Rheumatology Authors: Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan and Miaojia Zhang Tags: Correction Source Type: research

GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh çet’s disease
The objective of the present study was to clarify the pathological roles of CCR1 and IL10 l... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 12, 2018 Category: Rheumatology Authors: Hiroto Nakano, Yohei Kirino, Mitsuhiro Takeno, Kana Higashitani, Hideto Nagai, Ryusuke Yoshimi, Yukie Yamaguchi, Ikuma Kato, Ichiro Aoki and Hideaki Nakajima Tags: Research article Source Type: research

Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1- γ autoantibodies in adult patients with myositis
The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultravio... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2018 Category: Rheumatology Authors: Joanna E. Parkes, Simon Rothwell, Alexander Oldroyd, Hector Chinoy and Janine A. Lamb Tags: Research article Source Type: research

Serum IL-33 level is associated with auto-antibodies but not with clinical response to biologic agents in rheumatoid arthritis
Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis (ROC), registered 22 October 2009, NCT01000441 (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2018 Category: Rheumatology Authors: Elodie Rivi ère, Jérémie Sellam, Juliette Pascaud, Philippe Ravaud, Jacques-Eric Gottenberg and Xavier Mariette Tags: Letter Source Type: research

Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis
Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished n... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2018 Category: Rheumatology Authors: Unnikrishnan M. Chandrasekharan, Zeneng Wang, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen, Sihe Wang and M. Elaine Husni Tags: Research article Source Type: research

Could low birth weight and preterm birth be associated with significant burden of hip osteoarthritis? A systematic review
Approaches for the prevention and treatment of hip osteoarthritis (OA) remain limited. There are recent data suggesting that low birth weight (LBW) and preterm birth may be risk factors for hip osteoarthritis.... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2018 Category: Rheumatology Authors: Sultana Monira Hussain, Ilana N. Ackerman, Yuanyuan Wang, Ella Zomer and Flavia M. Cicuttini Tags: Review Source Type: research

Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis
The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship betwe... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2018 Category: Rheumatology Authors: Dan min Wang, Ling Lin, Jian hua Peng, Yao Gong, Zhi duo Hou, Su biao Chen and Zheng yu Xiao Tags: Research article Source Type: research

H1-antihistamines are associated with lower prevalence of radiographic knee osteoarthritis: a cross-sectional analysis of the Osteoarthritis Initiative data
There is growing evidence that mast cells (MCs) play a role in knee osteoarthritis (OA). H1-antihistamines block H1-receptors of histamine, which is an important mediator of MCs. There is a lack of data on whethe... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2018 Category: Rheumatology Authors: Ivan Shirinsky and Valery Shirinsky Tags: Research article Source Type: research

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
IL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony anky... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2018 Category: Rheumatology Authors: Sungsin Jo, Sung Eun Wang, Young Lim Lee, Suman Kang, Bitnara Lee, Jinil Han, Il-Hoon Sung, Ye-Soo Park, Sang-Cheol Bae and Tae-Hwan Kim Tags: Research article Source Type: research

Secukinumab provides rapid and sustained pain relief in psoriatic arthritis over 2 years: results from the FUTURE 2 study
Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2018 Category: Rheumatology Authors: Iain B. McInnes, Philip J. Mease, Georg Schett, Bruce Kirkham, Vibeke Strand, Nicole Williams, Todd Fox, Luminita Pricop, Steffen M. Jugl and Kunal K. Gandhi Tags: Research article Source Type: research

Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis
This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed syno... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2018 Category: Rheumatology Authors: Estefan ía Armas-González, María Jesús Domínguez-Luis, Ana Díaz-Martín, Mayte Arce-Franco, Javier Castro-Hernández, Gabriela Danelon, Vanesa Hernández-Hernández, Sagrario Bustabad-Reyes, Alberto Cantabrana, Mariagrazia Uguccioni and Federico Dí Tags: Research article Source Type: research

The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients
Aerobic exercise in general and high-intensity interval training (HIIT) specifically is known to improve vascular function in a range of clinical conditions. HIIT in particular has demonstrated improvements in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 5, 2018 Category: Rheumatology Authors: A. Mitropoulos, A. Gumber, H. Crank, M. Akil and M. Klonizakis Tags: Research article Source Type: research

Metabolomics approach by 1H NMR spectroscopy of serum reveals progression axes for asymptomatic hyperuricemia and gout
Gout is a metabolic disease and is the most common form of inflammatory arthritis affecting men. However, the pathogenesis of gout is still uncertain, and novel biomarkers are needed for early prediction and d... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 5, 2018 Category: Rheumatology Authors: Yannan Zhang, Huanzhen Zhang, Dong Chang, Fuchuan Guo, Hongzhi Pan and Yuexin Yang Tags: Research article Source Type: research

Gout and the risk of myocardial infarction in older adults: a study of Medicare recipients
Current evidence suggests that gout is independently associated with a higher risk of myocardial infarction (MI), but data in older adults at the highest risk of MI are lacking. Our objective was to examine wh... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2018 Category: Rheumatology Authors: Jasvinder A. Singh and John D. Cleveland Tags: Research article Source Type: research

Association between inflammation and systolic blood pressure in RA compared to patients without RA
In this study, we examined the association between inflammation and BP across a broader range of... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2018 Category: Rheumatology Authors: Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon and Katherine P. Liao Tags: Research article Source Type: research

Comorbidity in gout at the time of first diagnosis: sex differences that may have implications for dosing of urate lowering therapy
The aim of this study is to examine the occurrence of comorbidities at the time of first diagnosis of gout compared with matched population controls, overall and by sex, as well as to examine the crude and age... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2018 Category: Rheumatology Authors: Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Sv ärd, Lennart T. H. Jacobsson and Mats Dehlin Tags: Research article Source Type: research

How patients with gout become engaged in disease management: a constructivist grounded theory study
Prior qualitative research on gout has focused primarily on barriers to disease management. Our objective was to use patients ’ perspectives to construct an explanatory framework to understand how patients beco... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2018 Category: Rheumatology Authors: Alyssa Howren, Susan M. Cox, Kam Shojania, Sharan K. Rai, Hyon K. Choi and Mary A. De Vera Tags: Research article Source Type: research

Comparison of US patient, rheumatologist, and dermatologist perceptions of psoriatic disease symptoms: results from the DISCONNECT study
This study identified and compared the patient and dermatologi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2018 Category: Rheumatology Authors: M. Elaine Husni, Anthony Fernandez, Brett Hauber, Rakesh Singh, Joshua Posner, Jessie Sutphin and Arijit Ganguli Tags: Research article Source Type: research

Methotrexate: who would have predicted its importance in rheumatoid arthritis?
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 30, 2018 Category: Rheumatology Authors: Michael E. Weinblatt Tags: Editorial Source Type: research

From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology
Long-term cell cultures developed early in the twentieth century allowed identification in their supernatants of biological mediators subsequently defined as migration factors, interferons, lymphokines, monoki... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 30, 2018 Category: Rheumatology Authors: Jean-Michel Dayer Tags: Commentary Source Type: research

The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study
Evidence is emerging that pain in rheumatoid arthritis (RA) exists without underlying inflammation. Our objective was to evaluate the prognostic value of pain classification at treatment initiation using the p... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 30, 2018 Category: Rheumatology Authors: Signe Rifbjerg-Madsen, Anton Wulf Christensen, Mikael Boesen, Robin Christensen, Bente Danneskiold-Sams øe, Henning Bliddal, Lene Dreyer, Henning Locht and Kirstine Amris Tags: Research article Source Type: research

Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 30, 2018 Category: Rheumatology Authors: Antonio Juli à, Francisco Javier López-Longo, José J. Pérez Venegas, Silvia Bonàs-Guarch, Àlex Olivé, José Luís Andreu, Mª. Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco de la Fuente, Antonio Zea, José María Pego-R Tags: Research article Source Type: research

Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis
The term systemic juvenile idiopathic arthritis (sJIA) describes an autoinflammatory condition characterized by arthritis and severe systemic inflammation, which in later stages can transform into interleukin ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 30, 2018 Category: Rheumatology Authors: Boris H ügle, Anastasia Schippers, Nadine Fischer, Kim Ohl, Bernd Denecke, Fabio Ticconi, Bas Vastert, Ivan G. Costa, Johannes-Peter Haas and Klaus Tenbrock Tags: Research article Source Type: research

The lack of association between the burden of monosodium urate crystals assessed with dual-energy computed tomography or ultrasonography with cardiovascular risk in the commonly high-risk gout patient
The objective of this study was to explore the relationship between the extent of monosodium urate (MSU) crystal deposit... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 29, 2018 Category: Rheumatology Authors: Tristan Pascart, Benoist Capon, Agathe Grandjean, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, H élène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak and Jean-François Budzik Tags: Research article Source Type: research

Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis
In this study, we examined the effect of oxidative stress on cellular energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary rheumatoid arthritis synovial fibroblast cells (RASFC) and huma... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 29, 2018 Category: Rheumatology Authors: Emese Balogh, Douglas J. Veale, Trudy McGarry, Carl Orr, Zoltan Szekanecz, Chin-Teck Ng, Ursula Fearon and Monika Biniecka Tags: Research article Source Type: research