Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and several internal organs, including lungs. Macrophages are the main cells i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 20, 2024 Category: Rheumatology Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo Tags: Research Source Type: research
Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome
Treatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensive treatment option for patients with severe forms of systemic sclerosis (SSc). Even th... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 20, 2024 Category: Rheumatology Authors: Ann-Christin Pecher, Reinhild Klein, Ina Koetter, Marieke Wagner, Wichard Vogel, Stefan Wirths, Claudia Lengerke and Joerg Christoph Henes Tags: Research Source Type: research
Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis
Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 16, 2024 Category: Rheumatology Authors: Sabrina Pollastro, Anne Musters, Giulia Balzaretti, Ilse Niewold, Barbera van Schaik, Signe H ässler, Catharina M. Verhoef, Marc Pallardy, Antoine van Kampen, Xavier Mariette and Niek de Vries Tags: Research Source Type: research
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis
Transferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we aim to investigate the role of TfR1 in OA progression and its underly... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 16, 2024 Category: Rheumatology Authors: Wenchao Wang, Zhenkai Ma, Xuemin Feng, Jiabin Ren, Shengyao Sun, Yuandong Shao, Weimin Zhang, Xiaoxia Yang, Jiaming Zhang and Xingzhi Jing Tags: Research Source Type: research
The prevalence of sarcopenia in spondyloarthritis patients: a meta-analysis
Spondyloarthritis (SpA) is a chronic inflammatory disorder that affects sacroiliac joints and spine, resulting in substantial disability. Sarcopenia, characterized by the loss of muscle mass and function, is a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 16, 2024 Category: Rheumatology Authors: Jiawen Hu, Yiwen Wang, Xiaojian Ji, Yinan Zhang, Kunpeng Li and Feng Huang Tags: Research Source Type: research
Concomitant Sj ögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss clinical quality management cohort
To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without concomitant Sj ögren’s disease (SjD). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 14, 2024 Category: Rheumatology Authors: Lisa Christ, Seraphina Kissling, Axel Finckh, Benjamin A. Fisher, Sabine Adler, Britta Maurer, Burkhard M öller and Florian Kollert Tags: Research Source Type: research
Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection
To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 14, 2024 Category: Rheumatology Authors: Mojca Zajc Avramovi č, Nataša Toplak, Gašper Markelj, Nina Emeršič and Tadej Avčin Tags: Research Source Type: research
Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study
To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia (SLE-TP). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 12, 2024 Category: Rheumatology Authors: Jun Li, Liying Peng, Lijun Wu, Yufang Ding, Xinwang Duan, Jian Xu, Wei Wei, Zhen Chen, Cheng Zhao, Min Yang, Nan Jiang, Shangzhu Zhang, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng & hellip; Tags: Research Source Type: research
Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations
CRISPR-Cas9-based genome engineering represents a powerful therapeutic tool for cartilage tissue engineering and for understanding molecular pathways driving cartilage diseases. However, primary chondrocytes a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 11, 2024 Category: Rheumatology Authors: Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F. Bruhin, Alexis Laurent, Lee Ann Applegate, Marcy Zenobi-Wong and Goncalo Barreto Tags: Research Source Type: research
Effect of remission, clinical remission with active serology, and glucocorticoid dosage on the pregnancy outcome of pregnant patients with systemic lupus erythematosus
Remission is a key treatment target in systemic lupus erythematosus (SLE) management. Given the direct correlation between lupus flares and elevated risks of adverse pregnancy outcomes (APOs), securing remissi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 9, 2024 Category: Rheumatology Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada Tags: Research Source Type: research
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 9, 2024 Category: Rheumatology Authors: Chen Cheng, Hao Yang, Chan Yang, Juan Xie, Jinshen Wang, Luping Cheng, Jianfu He, Honglian Li, Haoxing Yuan, Fangfang Guo, Minmin Li and Shuwen Liu Tags: Research Source Type: research
Low CD4 + T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnan... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 9, 2024 Category: Rheumatology Authors: Agnes Torell, Marit Stockfelt, Kaj Blennow, Henrik Zetterberg, Tansim Akhter, Dag Leonard, Lars R önnblom, Sofia Pihl, Muna Saleh, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A. Bengtsson, Estelle Trysberg, Maria Majczuk Sennström, Ag Tags: Research Source Type: research
B cell receptor repertoire analysis in primary Sjogren ’s syndrome salivary glands identifies repertoire features associated with clinical activity
Primary Sjogren ’s syndrome (pSS) is a complex autoimmune disease featuring damage to salivary and lacrimal glands, with the possibility of manifestations across multiple organs. Antibody-producing B cells have... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 7, 2024 Category: Rheumatology Authors: Ling Chang, Zihan Zheng, Yiwen Zhou, Kun Liu, Yinong Li, Bing Zhong, Zihua Zhao, Chengshun Chen, Can Qian, Qingshan Ni, Qinghua Zou, Yuzhang Wu, Jingyi Li and Liyun Zou Tags: Research Source Type: research
Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis
Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient ’s response to these therapies. Prostanoi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 5, 2024 Category: Rheumatology Authors: Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordstr öm, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmoham Tags: Research Source Type: research
Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies
This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 4, 2024 Category: Rheumatology Authors: Meijiao Wang, Huanpeng Gu, Yingqi Zhai, Xuanlin Li, Lin Huang, Haichang Li, Zhijun Xie and Chengping Wen Tags: Review Source Type: research
