Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and several internal organs, including lungs. Macrophages are the main cells i...

Source: Arthritis Research and Therapy - March 20, 2024 Category: Rheumatology Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo Tags: Research Source Type: research