Distinct uric acid trajectories are associated with incident cardiac conduction block
The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 27, 2024 Category: Rheumatology Authors: Na Li, Liufu Cui, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Gary Tse, Nan Zhang, Xuemei Yang, Wenqi Xu, Shouling Wu and Tong Liu Tags: Research Source Type: research
Impact of multimorbidity on the first ts/bDMARD effectiveness and retention rate after two years of follow-up in patients with rheumatoid arthritis from the BIOBADASER registry
Patients with Rheumatoid Arthritis (RA) have a higher prevalence of comorbidities compared to the general population. However, the implications of multimorbidity on therapeutic response and treatment retention... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 23, 2024 Category: Rheumatology Authors: Jerusalem Calvo-Guti érrez, Clementina López-Medina, Lucía Otero-Varela, Alejandro Escudero-Contreras, Rafaela Ortega-Castro, Lourdes Ladehesa-Pineda, Cristina Campos, Pilar Bernabeu-Gonzalvez, Ana Pérez-Gómez, Alicia García-Dorta, Dolores Ruiz-Mont Tags: Research Source Type: research
Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome
The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with the nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 23, 2024 Category: Rheumatology Authors: Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu and Min Shen Tags: Research Source Type: research
Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes disability worldwide. Exosomes released by fibroblast-like synoviocytes in RA (RA-FLSs-Exos) play a role in the development of RA, and ci... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 22, 2024 Category: Rheumatology Authors: Guoqing Li, Yuxuan Fang, Nan Xu, Yimin Ding and Dan Liu Tags: Research Source Type: research
Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network
Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus ne... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 20, 2024 Category: Rheumatology Authors: Peter M. Izmirly, Mimi Y. Kim, Philip M. Carlucci, Katherine Preisinger, Brooke Z. Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall ’Era, Kenneth Kalunian, Andrea Fava, H. Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L. Bar Tags: Research Source Type: research
Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease
IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obli... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 20, 2024 Category: Rheumatology Authors: Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata, Masahiro Kiuchi, Kota Kokubo, Tomohisa Iinuma, Takahiro Sugiyama, Toyoyuki Hanazawa, Kiyoshi Hirahara, Kei Ikeda and Hiroshi Nakajima Tags: Research Source Type: research
Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they re... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 17, 2024 Category: Rheumatology Authors: Akshay Pandey, Mamta Singla, Ana Geller, Stuart B. Goodman and Nidhi Bhutani Tags: Research Source Type: research
Regulatory T and B cells in pediatric Henoch –Schönlein purpura: friends or foes?
Henoch –Schönlein purpura (HSP) is the most common immunoglobulin A-mediated systemic vasculitis in childhood. We studied immune dysregulation in HSP by analyzing regulatory T (Treg), T helper 3 (Th3), and regu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 16, 2024 Category: Rheumatology Authors: Anne Filleron, Renaud Cezar, Marc Fila, Nastassja Protsenko, Kathleen Van Den Hende, Eric Jeziorski, Bob Occean, Thierry Chevallier, Pierre Corbeau and Tu Anh Tran Tags: Research Source Type: research
Improvement in work productivity among psoriatic arthritis patients treated with biologic or targeted synthetic drugs: a systematic literature review and meta-analysis
Capacity to work is impacted by psoriatic arthritis (PsA). Our objective was to describe the course of work productivity and leisure activity in patients with PsA treated with biologic (b) and targeted synthet... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 15, 2024 Category: Rheumatology Authors: Laure Gossec, Brittany Humphries, Megan Rutherford, Vanessa Taieb, Damon Willems and William Tillett Tags: Review Source Type: research
Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis
Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 15, 2024 Category: Rheumatology Authors: Liam J. O ’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema and Hani El-Gabalawy Tags: Correspondence Source Type: research
Evaluating the safety profile of calcineurin inhibitors: cancer risk in patients with systemic lupus erythematosus from the LUNA registry —a historical cohort study
Previous studies have shown conflicting evidence regarding the incidence of cancer in patients with systemic lupus erythematosus (SLE) compared with that in healthy individuals. Calcineurin inhibitors (CNIs) s... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 12, 2024 Category: Rheumatology Authors: Kunihiro Ichinose, Shuntaro Sato, Takashi Igawa, Momoko Okamoto, Ayuko Takatani, Yushiro Endo, Sosuke Tsuji, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Nobuyuki Yajima Tags: Research Source Type: research
Long-term safety of Ixekizumab in adults with psoriasis, psoriatic arthritis, or axial spondyloarthritis: a post-hoc analysis of final safety data from 25 randomized clinical trials
We report long-term, end-of-study program safety outcomes from 25 randomized clinical trials (RCTs) in adult patients with psoriasis (PsO), psoriatic arthritis (PsA), or axial spondyloarthritis (axSpA) [includ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 12, 2024 Category: Rheumatology Authors: Atul Deodhar, Andrew Blauvelt, Mark Lebwohl, Meghan Feely, Andris Kronbergs, Nadezhda Eberhart, Danting Zhu, Elsa Inman, Elsie Grace, Thorsten Holzkaemper, Proton Rahman, Helena Marzo-Ortega, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb and Sergio Sch Tags: Research Source Type: research
Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis
Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been e... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 10, 2024 Category: Rheumatology Authors: Daeun Kim, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Junghyun Jung and Wonhee Jang Tags: Research Source Type: research
Manifestations and management of Sj ögren’s disease
Sj ögren’s disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2024 Category: Rheumatology Authors: Mehrnaz Maleki-Fischbach, Liudmila Kastsianok, Matthew Koslow and Edward D. Chan Tags: Review Source Type: research
Prediction of ineffectiveness of biological drugs using machine learning and explainable AI methods: data from the Austrian Biological Registry BioReg
Machine learning models can support an individualized approach in the choice of bDMARDs. We developed prediction models for 5 different bDMARDs using machine learning methods based on patient data derived from... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 8, 2024 Category: Rheumatology Authors: Dubravka Ukalovic, Burkhard F. Leeb, Bernhard Rintelen, Gabriela Eichbauer-Sturm, Peter Spellitz, Rudolf Puchner, Manfred Herold, Miriam Stetter, Vera Ferincz, Johannes Resch-Passini, Jochen Zwerina, Marcus Zimmermann-Rittereiser and Ruth Fritsch-Stork Tags: Research Source Type: research
