A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis
Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with differen... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 11, 2019 Category: Rheumatology Authors: Hai Qin Xie, Wei Wei Zhang, De Sheng Sun, Xiang Mei Chen, Shu Fang Yuan, Zheng Hua Gong and Li Liu Tags: Research article Source Type: research

Synovial tissue biopsy analysis: unlocking the hidden secrets to personalised medicine?
Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 8, 2019 Category: Rheumatology Authors: Helen Michelle McGettrick Tags: Editorial Source Type: research

Withdrawal of infliximab therapy in ankylosing spondylitis in persistent clinical remission, results from the REMINEA study
Recent data suggest that anti-TNF doses can be reduced in ankylosing spondylitis (AS) patients. Some authors even propose withdrawing treatment in patients in clinical remission; however, at present there is n... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 5, 2019 Category: Rheumatology Authors: Mireia Moreno, Jordi Gratac ós, Vicenç Torrente-Segarra, Raimon Sanmarti, Rosa Morlà, Caridad Pontes, Maria Llop and Xavier Juanola Tags: Research article Source Type: research

Safety and efficacy of tofacitinib for up to 9.5  years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study
Final data are presented for the ORAL Sequel long-term extension (LTE) study evaluating the safety and efficacy of tofacitinib 5  mg and 10 mg twice daily (BID) for up to 9.5 years in patients with rheumatoid a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 5, 2019 Category: Rheumatology Authors: J ürgen Wollenhaupt, Eun-Bong Lee, Jeffrey R. Curtis, Joel Silverfield, Ketti Terry, Koshika Soma, Chris Mojcik, Ryan DeMasi, Sander Strengholt, Kenneth Kwok, Irina Lazariciu, Lisy Wang and Stanley Cohen Tags: Research article Source Type: research

Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature
Data on survival and prognosis factors in incident cohorts are scarce in systemic sclerosis (SStc). To describe survival, standardized mortality ratio (SMR), and prognosis factors in systemic sclerosis (SSc), ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 3, 2019 Category: Rheumatology Authors: M. R. Pokeerbux, J. Giovannelli, L. Dauchet, L. Mouthon, C. Agard, J. C. Lega, Y. Allanore, P. Jego, B. Bienvenu, S. Berthier, A. Mekinian, E. Hachulla and D. Launay Tags: Research article Source Type: research

Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis
Abnormal glycolytic metabolism contributes to joint inflammation and destruction in rheumatoid arthritis (RA). We examine the expression and function of hexokinases in RA and evaluate the potential of their sp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 3, 2019 Category: Rheumatology Authors: Guanhua Song, Qiqi Lu, Hua Fan, Xiumei Zhang, Luna Ge, Ruisong Tian, Shiguan Wang, Tingting Feng, Jihong Pan, Jingjing Feng, Yabo Xiao, Xin Yi, Ningxin Ren and Lin Wang Tags: Research article Source Type: research

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival
Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in diseas... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 2, 2019 Category: Rheumatology Authors: DeAnna Baker Frost, Bethany Wolf, Christine Peoples, Jessica Fike, Katherine Silver, Maureen Laffoon, Thomas A. Medsger Jr and Carol Feghali-Bostwick Tags: Research article Source Type: research

An open-label extension study to demonstrate long-term safety and efficacy of ABP 501 in patients with rheumatoid arthritis
ABP 501 was evaluated in a phase 3 single-arm, open-label extension (OLE) study to collect additional safety and efficacy data in patients with rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 29, 2019 Category: Rheumatology Authors: Stanley Cohen, Jose L. Pablos, Karel Pavelka, Gerard Anton M üller, Alan Matsumoto, Alan Kivitz, Hui Wang and Eswar Krishnan Tags: Research article Source Type: research

Consequences of bariatric surgery on outcomes in rheumatic diseases
Obesity is associated with numerous comorbidities including some rheumatic conditions. Through adipose-derived inflammation, obesity has been shown to induce increased initiation, progression, and worse respon... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 28, 2019 Category: Rheumatology Authors: Eric Lespessailles, Emneh Hammoud, Hechmi Toumi and Nada Ibrahim-Nasser Tags: Review Source Type: research

Cause or effect? Interpreting emerging evidence for dysbiosis in systemic sclerosis
Systemic sclerosis (SSc) is an immune-mediated fibrotic disease affecting skin, lung and gut which are all sites with an established microbiome. Altered microbial flora may occur and contribute to the initiati... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 27, 2019 Category: Rheumatology Authors: Christopher P. Denton and Charles Murray Tags: Editorial Source Type: research

Incidence and survival impact of pulmonary arterial hypertension among patients with systemic lupus erythematosus: a nationwide cohort study
No population-based study has investigated the cumulative incidence of pulmonary arterial hypertension (PAH) in patients with newly diagnosed systemic lupus erythematosus (SLE) or the survival impact of PAH in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 27, 2019 Category: Rheumatology Authors: Hung-An Chen, Tsai-Ching Hsu, Su-Ching Yang, Chia-Tse Weng, Chun-Hsin Wu, Chien-Yao Sun and Chun-Yu Lin Tags: Research article Source Type: research

The Fatigue Assessment Scale as a simple and reliable tool in systemic lupus erythematosus: a cross-sectional study
The vast majority of patients with systemic lupus erythematosus (SLE) complain about fatigue. They also report fatigue as one of their most debilitating symptoms. Yet, in clinical practice, fatigue is only rar... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 25, 2019 Category: Rheumatology Authors: Alice Horisberger, Delphine Courvoisier and Camillo Ribi Tags: Research article Source Type: research

The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients
ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 20, 2019 Category: Rheumatology Authors: Blanka Stiburkova, Katerina Pavelcova, Marketa Pavlikova, Pavel Je šina and Karel Pavelka Tags: Research article Source Type: research

Hypoxia-induced miR-191-C/EBP β signaling regulates cell proliferation and apoptosis of fibroblast-like synoviocytes from patients with rheumatoid arthritis
This study was conducted to evaluate hypoxia-induced microRNAs (h... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 20, 2019 Category: Rheumatology Authors: Shanshan Yu, Ying Lu, Ming Zong, Qi Tan and Lieying Fan Tags: Research article Source Type: research

Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan
Sarilumab is a human immunoglobulin G1 anti-interleukin-6 (IL-6) receptor monoclonal antibody that blocks IL-6 from binding to membrane-bound and soluble IL-6 receptor α. This bridging study assessed the effic... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 20, 2019 Category: Rheumatology Authors: Yoshiya Tanaka, Kazuteru Wada, Yoshinori Takahashi, Owen Hagino, Hubert van Hoogstraten, Neil M. H. Graham and Hideto Kameda Tags: Research Source Type: research

Role of lectin pathway complement proteins and genetic variants in organ damage and disease severity of systemic sclerosis: a cross-sectional study
This study investigated the role of the lectin pathway of complement as a mediator of ischemia/reperfusion in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 18, 2019 Category: Rheumatology Authors: Michael Osthoff, Veronika K. Jaeger, Ingmar A. F. M. Heijnen, Marten Trendelenburg, Suzana Jordan, Oliver Distler and Ulrich A. Walker Tags: Research article Source Type: research

Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis
The 17DD-yellow fever (YF) vaccine induces a long-lasting protective immunity, resulting from humoral and cellular immunological memory. The treatment of rheumatoid arthritis (RA) patients with disease-modifyi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 14, 2019 Category: Rheumatology Authors: Clarissa de Castro Ferreira, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalh āes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Karen Torres, Larissa Chaves Freire, Ismael Artur da Costa-Rocha, Ana Cristina Vanderley Oliveira, Ma Tags: Research article Source Type: research

Divergent roles of prostacyclin and PGE2 in human tendinopathy
Tendon disease is a significant global healthcare burden whereby patients experience pain and disability; however, the mechanisms that underlie inflammation and pain are poorly understood. Herein, we investiga... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 13, 2019 Category: Rheumatology Authors: Filip Bergqvist, Andrew J. Carr, Kim Wheway, Bridget Watkins, Udo Oppermann, Per-Johan Jakobsson and Stephanie G. Dakin Tags: Research article Source Type: research

In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis
Resolvin D1 (RvD1), an important member of resolvins, exerts a wide spectrum of biological effects, including resolution of inflammation, tissue repair, and preservation of cell viability. The aim of the present ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 12, 2019 Category: Rheumatology Authors: Houda Abir Benabdoun, Merve Kulbay, Elsa-Patricia Rondon, Francis Valli ères, Qin Shi, Julio Fernandes, Hassan Fahmi and Mohamed Benderdour Tags: Research article Source Type: research

High serum uric acid level is associated with greater handgrip strength in the aged population
We aimed to investigate the association of serum UA level with muscle strength assessed by handgrip strength (HGS) in a large Korean adult population. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 12, 2019 Category: Rheumatology Authors: Jennifer Lee, Yeon Sik Hong, Sung-Hwan Park and Kwi Young Kang Tags: Research article Source Type: research

Invasive mycoses in patients with connective tissue disease from Southern China: clinical features and associated factors
A retrospective study was performed to investigate the clinical features and associated factors of invasive mycoses (IM) in patients with connective tissue disease (CTD) from Southern China. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 11, 2019 Category: Rheumatology Authors: Minxi Lao, Zhongping Zhan, Fan Su, Hao Li, Zheng Yang, Haihong Chen, Liuqin Liang and Dongying Chen Tags: Research article Source Type: research

Full high-throughput sequencing analysis of differences in expression profiles of long noncoding RNAs and their mechanisms of action in systemic lupus erythematosus
The specific function of long noncoding RNAs (lncRNAs) in systemic lupus erythematosus (SLE) and the mechanism of their involvement in related pathological changes remain to be elucidated, so, in this study, w... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 5, 2019 Category: Rheumatology Authors: Hui Ye, Xue Wang, Lei Wang, Xiaoying Chu, Xuanxuan Hu, Li Sun, Minghua Jiang, Hong Wang, Zihan Wang, Han Zhao, Xinyu Yang and Jianguang Wang Tags: Research article Source Type: research

Correction to: Efficacy of canakinumab as first-line biologic agent in adult-onset Still ’s disease
Following publication of the original article [1], the authors reported an error in the spelling of Lorenzo Dagna ’s name. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 25, 2019 Category: Rheumatology Authors: Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A. Dinarello, Elena Baldissera and Lorenzo Dagna Tags: Correction Source Type: research

Multisite pain and self-reported falls in older people: systematic review and meta-analysis
This study aims to synthesise published literature to further explore ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 22, 2019 Category: Rheumatology Authors: Victoria K. Welsh, Lorna E. Clarson, Christian D. Mallen and John McBeth Tags: Research article Source Type: research

Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model
Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammati... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 22, 2019 Category: Rheumatology Authors: Anna Katri, Aneta D ąbrowska, Henrik Löfvall, Ming Ding, Morten A. Karsdal, Kim V. Andreassen, Christian S. Thudium and Kim Henriksen Tags: Research article Source Type: research

Association between concomitant csDMARDs and clinical response to TNF inhibitors in overweight patients with axial spondyloarthritis
The aim of our study was to investigate the influence of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and body mass index (BMI) on circulating drug levels and clinical response to t... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 20, 2019 Category: Rheumatology Authors: Borja Hern ández-Breijo, Chamaida Plasencia-Rodríguez, Victoria Navarro-Compán, Ana Martínez-Feito, Andrea Jochems, Eva L. Kneepkens, Gerrit J. Wolbink, Theo Rispens, Cristina Diego, Dora Pascual-Salcedo and Alejandro Balsa Tags: Research article Source Type: research

Health-related quality of life in patients with giant cell arteritis treated with tocilizumab in a phase 3 randomised controlled trial
Patients with giant cell arteritis (GCA) treated with tocilizumab (TCZ) every week or every other week and prednisone tapering achieved superior rates of sustained remission to patients treated with placebo an... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 20, 2019 Category: Rheumatology Authors: Vibeke Strand, Sophie Dimonaco, Katie Tuckwell, Micki Klearman, Neil Collinson and John H. Stone Tags: Research article Source Type: research

Response to: “A somatization comorbidity phenotype impacts response to therapy in rheumatoid arthritis: post hoc results from the certolizumab pegol phase 4 PREDICT trial”
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 20, 2019 Category: Rheumatology Authors: Annelise Madison, Barbara L. Andersen and Ali Ajam Tags: Letter Source Type: research

Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8  years in 1347 patients with early arthritis and early inflammatory back pain
The objectives were to describe the changes in HRQoL over 5 –8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 19, 2019 Category: Rheumatology Authors: D éborah Puyraimond-Zemmour, Benjamin Granger, Anna Molto, Cécile Gaujoux-Viala, Francis Guillemin, Adeline Ruyssen-Witrand, Maxime Dougados, Bruno Fautrel and Laure Gossec Tags: Research article Source Type: research

Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sj ögren’s syndrome differ in molecular signatures and treatment perspectives
Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 18, 2019 Category: Rheumatology Authors: Helena Idborg, Arash Zandian, Ann-Sofi Sandberg, Bo Nilsson, Kerstin Elvin, Lennart Truedsson, Azita Sohrabian, Johan R önnelid, John Mo, Giorgia Grosso, Marika Kvarnström, Iva Gunnarsson, Janne Lehtiö, Peter Nilsson, Elisabet Svenungsson and Per-Johan Tags: Research article Source Type: research

Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study
Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 15, 2019 Category: Rheumatology Authors: Eun Hye Park, Vibeke Strand, Yoon Jeong Oh, Yeong Wook Song and Eun Bong Lee Tags: Research article Source Type: research

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients —immune-related candidate proteins affected by TNF blocking treatment
Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blo... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 15, 2019 Category: Rheumatology Authors: Johanna Estelius, Johan Lengqvist, Elena Ossipova, Helena Idborg, Erwan Le Ma ître, Magnus L. A. Andersson, Lou Brundin, Mohsen Khademi, Elisabet Svenungsson, Per-Johan Jakobsson and Jon Lampa Tags: Research article Source Type: research

Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease
Biomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression of connective tissue disease-associated interstit... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 14, 2019 Category: Rheumatology Authors: Jeong Seok Lee, Eun Young Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee and Yeong Wook Song Tags: Research article Source Type: research

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?
MRI-detected subclinical joint inflammation in the hand joints of patients with undifferentiated arthritis (UA) predicts progression to rheumatoid arthritis (RA). It is unknown if adding MRI of the foot increa... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 14, 2019 Category: Rheumatology Authors: Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse and A. H. M. van der Helm-van Mil Tags: Research article Source Type: research

Significance of anti-neutrophil cytoplasmic antibodies in systemic sclerosis
Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the signific... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 14, 2019 Category: Rheumatology Authors: Jayne Moxey, Molla Huq, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Gemma Strickland, Michelle Wilson, Laura Ross, Gabor Major, Janet Roddy, Wendy Stevens and Mandana Nikpour Tags: Research article Source Type: research

Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia
Ultrasound (US) and magnetic resonance imaging (MRI) are recommended in the diagnostic process of rheumatoid arthritis. Research on its comparability in early disease phases is scarce. Therefore, we compared s... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 14, 2019 Category: Rheumatology Authors: Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas and Annette H. M. van der Helm-van Mil Tags: Research article Source Type: research

Correction to: Clinical course and prognostic factors of childhood Takayasu ’s arteritis: over 15-year comprehensive analysis of 101 patients
Following publication of the original article [1], the authors reported an error. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 14, 2019 Category: Rheumatology Authors: Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu and Ying Lou Tags: Correction Source Type: research

Efficacy of canakinumab as first-line biologic agent in adult-onset Still ’s disease
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 13, 2019 Category: Rheumatology Authors: Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A. Dinarello, Elena Baldissera and Loreno Dagna Tags: Letter Source Type: research

Exocrine pancreatic function is preserved in systemic sclerosis
Systemic sclerosis (SSc) has been suggested to cause exocrine pancreatic dysfunction. However, a case-control-based autopsy study failed to associate systemic sclerosis with any pancreatic histopathology. The ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 12, 2019 Category: Rheumatology Authors: Gracijela Bozovic, Rille Pullerits, Arne St åhl, Kristina Ydström, Daniel Wenger, Jan Marsal, Pontus Thulin and Kristofer Andréasson Tags: Research article Source Type: research

Adult-onset Still ’s disease biological treatment strategy may depend on the phenotypic dichotomy
Adult-onset Still ’s disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more promine... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 12, 2019 Category: Rheumatology Authors: Fran çois Vercruysse, Thomas Barnetche, Estibaliz Lazaro, Emilie Shipley, François Lifermann, Alexandre Balageas, Xavier Delbrel, Bruno Fautrel, Christophe Richez, Thierry Schaeverbeke and Marie-Elise Truchetet Tags: Research article Source Type: research

Deregulation of microRNA expression in monocytes and CD4+ T lymphocytes from patients with axial spondyloarthritis
This study is the first to investigate miR expression profiles in purified CD4+ T lymphocytes and CD14+ monocytes from... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 12, 2019 Category: Rheumatology Authors: Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-Fran çois Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard and Jörg Tost Tags: Research article Source Type: research

New-onset non-infectious pulmonary manifestations among patients with systemic lupus erythematosus in Sweden
The objective was to estimate the incidence of lung disease among patients with systemic lupus erythematosus (SLE). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 6, 2019 Category: Rheumatology Authors: Lindsy J. Forbess, Marios Rossides, Michael H. Weisman and Julia F. Simard Tags: Research article Source Type: research

Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression
Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 6, 2019 Category: Rheumatology Authors: M. C. P. Cleophas, T. O. Cri şan, V. Klück, N. Hoogerbrugge, R. T. Netea-Maier, C. A. Dinarello, M. G. Netea and L. A. B. Joosten Tags: Research article Source Type: research

Rheumatoid arthritis reprograms circadian output pathways
We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 6, 2019 Category: Rheumatology Authors: Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou and David W. Ray Tags: Research article Source Type: research

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin
Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses of high-throughput data allows for the unbiased i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 6, 2019 Category: Rheumatology Authors: Michael E. Johnson, Jennifer M. Franks, Guoshuai Cai, Bhaven K. Mehta, Tammara A. Wood, Kimberly Archambault, Patricia A. Pioli, Robert W. Simms, Nicole Orzechowski, Sarah Arron and Michael L. Whitfield Tags: Research article Source Type: research

Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis
Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut. Rats transgenic for HLA-B27 and human β2-mi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 4, 2019 Category: Rheumatology Authors: K étia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M. Araujo, Gilles Chiocchia and Maxime Breban Tags: Research article Source Type: research

Anti-citrullinated protein antibodies are associated with osteopenia but not with pain at diagnosis of rheumatoid arthritis: data from the BARFOT cohort
Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addres... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 4, 2019 Category: Rheumatology Authors: Ingi äld Hafström, Sofia Ajeganova, Kristina Forslind and Björn Svensson Tags: Research Source Type: research

Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy
This study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadeniti... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 1, 2019 Category: Rheumatology Authors: Mu Wang, Panpan Zhang, Wei Lin, Yunyun Fei, Hua Chen, Jing Li, Li Zhang, Wenjie Zheng, Yongze Li, Xiaofeng Zeng, Jiaxin Zhou, Yamin Lai, Xiaowei Liu, Huadan Xue, Yueying Cui, Lian Zhou & hellip; Tags: Research article Source Type: research

IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study
An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4+) B cells and plasma cells are implicated in the pathogenesis of GPA. We... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 31, 2019 Category: Rheumatology Authors: A. Al-Soudi, M. E. Doorenspleet, R. E. Esveldt, L. T. Burgemeister, A. E. Hak, B. J. H. van den Born, S. W. Tas, R. F. van Vollenhoven, P. L. Klarenbeek and N. de Vries Tags: Research article Source Type: research

Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells
The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hyp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 31, 2019 Category: Rheumatology Authors: Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W. N. Ueng, Chuen-Yung Yang, Tsung-Ting Tsai and Po-Liang Lai Tags: Research article Source Type: research