Serum Proteomic Approach for Differentiation of Frail and Non-Frail Elderly
AbstractFrail elderly is very common in Indian society and extremely difficult to manage in the clinical practice. Blood proteomic study may able to improve the specific diagnostic profiles and therapeutic templates for improving quality of life in elderly. The purpose of present study is to differentiate between frail and non-frail elderly on the basis of serum markers. The proteomic profile of 10 frail and 10 non-frail elderly diagnosed according to deficit accumulation model of Rockwood was identified by 2D-electrophoresis and analyzed using ImageMaster 2D Platinum 7.0 software. The proteins were identified by MALDI-TOF...
Source: Advances in Gerontology - April 1, 2021 Category: Geriatrics Source Type: research
Molecular and Cellular Mechanisms of Osteoarthritis in Experimental Arterial Hypertension and Hyperlipidemia
AbstractRecent studies showed that pathologies associated with aging, such as cardiovascular disease and osteoarthritis (OA), can have several common molecular and cellular pathophysiological mechanisms. The conditions and extent of influence of arterial hypertension (AH) and hyperlipidemia (HL) on joint tissues remain unclear. This work investigates the role of vascular endothelial growth factor (VEGF-A), adiponectin (Adipo), and matrix metalloproteinase-9 (MMP-9) in the remodeling of articular cartilage (AC) and subchondral bone (SCB) in experimental AH and HL. The experimental study was carried out on 18 sexually mature...
Source: Advances in Gerontology - April 1, 2021 Category: Geriatrics Source Type: research
Why Do People Fear of Aging? A Theoretical Framework
AbstractFear of aging can be experienced by people of all age groups and negatively affects health and well-being. Fear of aging has been defined as irrational and persistent fear of getting older. It negatively affects health of younger and older adults. This paper aimed to propose a theoretical framework that explains causes of fear of aging. The authors reviewed and critiqued existing theories related to fear of aging. Then a new theoretical framework was developed using a deductive approach. Based on the gerontological literature, it was found that fear of aging is a multifactorial phenomenon and rooted from several ps...
Source: Advances in Gerontology - April 1, 2021 Category: Geriatrics Source Type: research
Prevalence of Micronutrient Deficiencies in Geriatric Bariatric Patients
AbstractObese individuals have high prevalence of thiamine deficiency and hypovitaminosis D. Our hypothesis is that geriatric, bariatric surgery patients are at risk for micronutrient deficiencies. In this retrospective study, 3 males and 30 females (gastric bypass:n = 27; vertical sleeve gastrectomy:n = 6) individuals were evaluated. Eight micronutrients are measured using commercial blood testing. Mean age is 70 yr, mean body mass index is 35 kg/m2, with a mean of 11 years after bariatric surgery. Hypovitaminosis D is identified in 32 of 33 patients. Low vitamin B12 is identified in 32%, low vitamin A in 16%, low vitamin...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
State of Autonomic Regulation of Heart Rhythm in Young and Old Rats before and after the Application of Different Regimens of Rhythmic Extreme Cooling
AbstractThe influence of various regimens of rhythmic, extreme cold effects on the state of autonomic regulation of the heart rate was studied in young and old rats. Spectral analysis of heart-rate variability found that the use of rhythmic extreme cold exposures (RECE) with temperature regimens of ( –120; –120; –120°С) and (–60; –120; –120°С) significantly increased the body’s adaptive capabilities in young rats due to the activation of their homeostatic regulatory systems. At the same time, the combined RECE regimen (‒60; –120; ‒120°С) appeared to be the most optimal for mature animals, since it...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Capacities and Limitations of the Use of Data from Wikipedia for Analysis of Human Life Expectancy
AbstractThe applicability of the data on the mean age of death (MAD) of people presented on Wikipedia to determine the survival patterns with respect to professional occupations is considered. The results of previous studies are described. Features of these data related to censorship and the selective nature of their collection are discussed. The proposed approach to account for these features makes it possible to clarify the obtained patterns and to expand the time range of the study. (Source: Advances in Gerontology)
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Melatonin Prevents the Development of Age-Related Pathology in Male Rats during Accelerated Aging Caused by Impaired Photoperiodism
AbstractThe purpose of the work was to study the role of melatonin in the development of age-related pathology and morbidity in male rats under model conditions of accelerated aging caused by impaired photoperiodism. Circadian-rhythm disruption upon exposure to light at night initiates the development of age-related changes in the body and contributes to the formation of age-associated diseases. The article presents the results of an experimental study showing that the use of melatonin in laboratory animals in various light regimes (standard lighting, natural lighting in northwest Russia, and constant lighting) significant...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Association between Cytokine Gene Polymorphisms and Breast Cancer in Postmenopausal Women
AbstractThe goal of this study was to investigate the association between the polymorphic loci of genesIL1B (rs16944),IL1RN (rs4251961),IL6 (rs1800795, rs1800796, rs1554606),IL8 (rs4073),IL10 (rs1800896), andTNFA (rs1800629) and breast cancer in women. The DNA samples of 521 women with breast cancer and 267 women without oncological pathology were studied. The study showed that age, concomitant chronic morbidity, and polymorphism of theIL6 gene are risk factors in postmenopausal women. Allele –572C (OR = 5.68; 95% CI = [2.70 –11.97],pcor< 0.001), and haplotype rs1800796[C] –rs1800795[G]–rs1554606[G] (OR = 5.31,...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Analytical Study of Patterns of the Survival Curves of Experimental Objects in Model Experiments on Daphnia magna
AbstractThe phenomenon of multiphasic survival curves found in drosophila is confirmed in experiments on daphnids. Mathematical modeling showed that the multiphasic nature of daphnids survival curves reflected abrupt changes in the death rate of objects during phase transition. The phase of a sharp increase in mortality observed at an early age in intact drosophila occurs in daphnids only as reaction to a negative impact. The induction of reactive changes by weak external signals resulted in decreased survival for young daphnids. A logical conclusion was made about the reaction readiness for each experimental individual. I...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Social Support, Happiness, and Self-Rated Health among Older Adults: A Population-Based Study
AbstractSuccessful aging is affected by multiple factors, including social support and mental health. In this investigation, the aim was to assess the association between Social support, happiness, and self-rated health among older adults. In this cross-sectional analytical descriptive study, 240 older adults were included using the multistage sampling method in Kerman, Iran. Data collection tools included: sociodemographic questionnaire, happiness self-rated health questionnaire, the Received Social Support Scale, and Perceived Social Support. The mean age of the elderly in the study was 66.74 ± 8.69 years. Regarding hap...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Study of the Nerve Apparatus and Mast Cells in the Hearts of Old Rats
AbstractA comparative study of the nerve structures and the density of mast cells in the heart of rats aged 3 –4 and 23 months was carried out with histological and histochemical methods and the immunohistochemical markers PGP 9.5, tyrosine hydroxylase (TH), and synaptophysin. It was found that tissues innervation decreases with aging in all studied heart areas, particularly, sympathetic innervation. A de crease in sympathetic plexus density and the presence of dystrophic and degenerative changes in TH-immunopositive axon terminals were registered. It was also demonstrated that the mast cell population in old animals inc...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Age-Related Features of the Relationship between the Content of Vascular Endothelial Growth Factor and the Parameters of the Lipid Metabolism and Extracellular Matrix Metabolism in Men of the European Part of the Russian Arctic
AbstractThe research studied the content of vascular endothelial growth factor A (VEGF-A) in blood plasma and its relationship with the lipid and extracellular matrix metabolism in men aged 19 –69 years living and working in the European part of the Arctic zone of the Russian Federation (Russian Arctic). No age specificity was found in the plasma VEGF-A content. A correlation analysis of different age groups found a significant correlation of the VEGF-A level with parameters of the lipi d (cholesterol, LDL-C, Apo B, atherogenicity coefficient, Apo B/Apo A1 ratio) and extracellular matrix metabolism (blood TIMP-4, MMP-2, ...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Social Environment of Elderly Living Accommodations and Its Determinants: Insight from Northeast India
AbstractThe demographic and social changes in India consequences increase the proportion of older adults in the population. Simultaneously, Indian society is transforming from the joint family to the nuclear family system. These two issues together administrated serious implications on the support and care of the elderly. The concept of the social environment of veterans living accommodations is important because it helps us identify the caregivers. With this backdrop, the study aims to get an overview of the status of veteran living arrangements of India ’s northeast and identification of the different social, economic ...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
Histological Changes in the Myocardial Structure of Old Hypertensive Rats under the Influence of Cryopreserved Nucleated Cells from Umbilical Cord Blood
AbstractThe work estimates histological changes in the myocardial structure of old, hypertensive rats after the introduction of cryopreserved cord-blood nucleated cells (CBNCs). The goal of the work was to estimate the structural organization of myocardial tissues and blood vessels on the third, seventh, and 30th days after the intraperitoneal administration of cryopreserved CBNCs to rats with stress-induced arterial hypertension. The experiments were carried out on 28- to 30-month-old, white, outbred, male rats. It was established that the introduction of cryopreserved CBNCs to old animals with stress-induced arterial hyp...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
AEDG Peptide Regulation of the Expression of Human Circadian Rhythm Genes upon Accelerated Aging of the Pineal Gland
AbstractNight work desynchronizes biorhythms, disturbs melatonin production, and accelerates pineal-gland aging. A promising geroprotector for the restoration of pineal melatonin synthesis is AEDG (Ala-Glu-Asp-Gly) peptide. AEDG peptide increases 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people by 1.7 times. Moreover, AEDG peptide normalizes the hyperexpression of theClock andCsnk1e circadian genes in leukocytes and increasesCry2 gene hypoexpression in peripheral blood lymphocytes by two times in people with reduced epiphyseal melatonin-production. The geroprotective effect of AEDG peptide is base...
Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research
