Geroprotective Effect of the Mitochondrial-Targeted Antioxidant SkQBerb in a Model of the Chronological Aging of MB135 Human Myoblasts
Conclusion: The findings of this study suggest the potential geroprotective and senomorphic effect of SkQBerb. These results open up possibilities for utilizing this mitochondrial-targeted compound as a geroprotector in future applications. (Source: Advances in Gerontology)
Source: Advances in Gerontology - June 1, 2023 Category: Geriatrics Source Type: research
Mitochondrial Antioxidant SkQ1 Affects the GABAergic but Not the Glutamatergic System in the Hippocampus of Wistar and Senescence Accelerated OXYS Rats
AbstractNumerous studies have shown that mitochondria-targeted antioxidant SkQ1 can increase the lifespan of many species and suppress the development of various age-related diseases. Previously we demonstrated that SkQ1 suppresses all manifestations of accelerated senescence in OXYS rats, including the development of the main signs of Alzheimer ’s disease (AD). GABA and glutamate are two of the most abundant neurotransmitters in the central nervous system, and it was showed that changes in their signaling accompany aging and the development of AD. Previously, we showed delicate age-related changes of the components of g...
Source: Advances in Gerontology - March 1, 2023 Category: Geriatrics Source Type: research
New Frailty Index Approach Predicts COVID-19 Mortality Risk
AbstractThe relationships between blood biomarkers, frailty, and the risk of death of people diagnosed with COVID-19 is unclear. In the current investigation we decided to analyze the collective effect of multiple biomarkers (laboratory markers of inflammation, blood biochemistry deviations, comorbidity, demographics) on mortality in people diagnosed with COVID-19. We analyzed baseline data of one hundred fifty-five patients (age range from twenty-six to ninety-four) diagnosed with COVID-19. Thirty-seven parameters (including major morbidities) were used to derive the frailty index (FI) and calculate the risk of death as a...
Source: Advances in Gerontology - March 1, 2023 Category: Geriatrics Source Type: research
Age-Related Changes in the Metabolomic Composition of Macaque (Macaca fascicularis) Ocular Tissues
AbstractThe study is aimed at determining age-related changes in ocular tissues of crab-eating macaque (Macaca fascicularis). To this end, we measured the concentrations of a total of 71 major metabolites in aqueous humor, vitreous humor, and lens of two groups of animals, young (4-year-old,n = 6) and aged (21-year-old and 27-year-old,n = 2) macaques. Significant age-related changes were revealed for all three tissues. In the lens, the most significant changes were found for cytoprotective compounds – antioxidants, osmolytes, and molecular ultraviolet (UV) filters: the concentrations of these metabolites in the lenses of...
Source: Advances in Gerontology - March 1, 2023 Category: Geriatrics Source Type: research
Reductionism and Holism in the History of Aging and Longevity Research: Does the Whole Have Parts? Part 1. The Building of Reductionism
AbstractThe research of aging, rejuvenation and life extension has been notoriously characterized by a multitude of often contradictory approaches, both in terms of theoretical concepts as well as possible practical interventions. This work will explore a general taxonomy of these approaches that seems to be ubiquitous in the history of aging and longevity research. The taxonomy will juxtapose between reductionist/therapeutic and holistic/hygienic approaches to potential rejuvenating and life-extending interventions. Both approaches sought to achieve biological equilibrium and constancy of internal environment, yet emphasi...
Source: Advances in Gerontology - March 1, 2023 Category: Geriatrics Source Type: research
Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135
AbstractGenotoxic and cytotoxic drugs, widely used in anticancer therapy, target proliferating cells and induce cell death through a variety of cell cycle-dependent mechanisms. The mechanisms of the delayed toxicity induced by chemotherapy are not fully understood. The accumulation of senescent cells may underlie some of the mechanisms for the development of late adverse effects of chemotherapy on muscle tissue. Cellular models are necessary for the development of therapeutic approaches to these side effects. In our study we used human immortalized myoblast MB135 to optimize the protocol for obtaining the senescent phenoty...
Source: Advances in Gerontology - March 1, 2023 Category: Geriatrics Source Type: research
Gerontology in the 21st Century: From Failures to Advances. Hopefully
AbstractEditor-in-Chief ofAdvances in Gerontology describes the current editorial policy and the strategy of future development of the renewed journal which since 2023 is published as a separate independent edition. It is emphasized that now priority is given to publications devoted to (1) the fundamental mechanisms which may determine the increase in the probability of death of living organisms, including humans, with age, and to (2) identifying various factors of both chemical and physical nature that could potentially help to slow down the aging process. In addition, papers included in Volume 13, Issue 1 are shortly rev...
Source: Advances in Gerontology - March 1, 2023 Category: Geriatrics Source Type: research
Effect of Physical Activity on Sleep Outcomes among Iranian Older Adults: A Cross-Sectional Study
This study was aimed to determine the effect of physical activity (PA) on sleep outcomes in older adults living in Birjand, Iran. This descriptive-analytical study was performed on 1740 individuals, ≥60 years in urban and rural regions of Birjand. The Longitudinal Ageing Study Amsterdam Physical Activity Questionnaire (LAPAQ), a sociodemographic and a sleep status questionnaire were used to collect data. Analyses of variance (ANOVA), univariate, multiple linear and logistic regressions were u sed to analyze the data. The average age of the participants was 69.73 ± 7.56 years. About 54.08% of participants had low physica...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
COVID-19 in Lifespan: Psychological Impact between Young and Older Adults in Argentina
This study aimed to analyze and compare the psychological impact, as measured by the presence of depressive and anxiety symptoms, in a group of young and older adults at three-time points during the pandemic. Virtual surveys were used to measure participants ’ symptomatology and collect socio-demographic information. The results showed a significant increase in anxiety and depression in the general population. However, when comparing the two groups, statistical differences were observed. Younger adults showed higher mean anxiety and depression than ol der adults, which was sustained across the three times for both groups...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
On the Role of Geriatric Services in the Diagnosis and Monitoring of Outcomes of Post-Covid Syndrome (Review)
This article summarizes the experience of foreign studies aimed at determining the duration and clarifying the nature of multi-organ complications after suffering from COVID-19, as well as ways of the long-term rehabilitation of patients in older age groups with post -COVID syndrome. (Source: Advances in Gerontology)
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
Influence of Perceived Ageism on Older Adults: Focus on Attitudes toward Young People and Life Satisfaction
This study focused on ageism as a cause of intergenerational conflicts and older adults’ diminished mental health status. We conducted an online survey of older Japanese parti cipants (n = 1.096). Our results indicated that older adults who perceived more ageism directed toward them (1) had more negative attitudes toward young people and (2) had lower life satisfaction, which persisted even after controlling for variables such as old age identity and depressive tendencies. Accordingly, we suggest that ageism may reinforce intergenerational conflicts between older adults and young people and compromise older adults ’ me...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
Post-Retirement Employment among Iranian Older Adults: The Competition of Two Generation
This study seeks to investigate the factor influencing post-retirement employment among the Iranian older adults. The participants consisted of 1280 elderly people over 60 years old in Tehran in 2020 and data analysis was done by using odds ratio, Logit and Probit regression as well as effect analysis. The results indicate that the job seeking behavior varies among older adults with different individual and social characteristics. The odds of working after retirement for the younger old adults and participants with better socio-economic status are more than other subgroups. While being female and having social insurance ...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
Peculiarities of Venous Trophic Ulcers Course in Gerontoligical Patients according to Local Immunity and Morphological Manifestations
AbstractAs organs age morpho-functional changes of organs and tissues become pathological disrupting the quality of life and providing an aggravating effect on the course of underlying disease which requires a special treatment approach. The research purpose is the study of particular features of the clinical, immunological and morphological manifestations of the venous trophic ulcers in the elderly and senile aged patients. All 375 patients are suffering from venous trophic ulcers have been examined. All the patients are divided into three age groups according to the WHO classification: 1st group (middle-aged) —94 patie...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
Neurological Complications and Consequences of the Novel Coronavirus COVID-19 Infection in Elderly and Senile Patients (Literature Review)
AbstractBased on available publications, the article systematizes information about some forms of lesions of the central nervous system (CNS), their pathogenesis and clinical manifestations in the case of COVID-19. The risk factors, mechanisms of development, diagnostic approach, and the age characteristics of patients with neurological complications of COVID-19 are discussed. The specific mechanisms of the neuroinvasiveness and neurovirulence of the SARS-CoV-2 virus, regardless of the age of patients and the presence of risk factors, lead to systemic damage to the endothelium of small-caliber vessels, generalized thrombov...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
Healthy Life Expectancy of People Over Age 65: Results of the Russian Epidemiological Study EVCALIPT
AbstractThe health of a population is an important indicator of the general well-being of the population, and it has its practical significance, as it determines the costs of providing care, and social and medical assistance for the elderly. The study presents an assessment of healthy life-expectancy indicators of people over age 65 based on the results of the Russian epidemiological study EVCALIPT and a comparison of this results with data from other surveys in Russia and European countries. (Source: Advances in Gerontology)
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research
