Changes in the Number of p23-Positive Fibroblasts in Human Dermis with Aging
AbstractThe aim of this work was to examine the content of p23 in fibroblasts of the human dermis from 20 weeks of gestation until 85 years old and to define the role of p23 in age-dependent changes in the number and proliferation of fibroblasts in the dermis. p23, proliferating cells nuclear antigen (PCNA), and the fibroblasts marker vimentin were detected with the indirect immunohistochemical techni que. The results showed that the portion of fibroblasts with positive staining for p23 in the dermis gradually increases from 20 weeks of gestation until 85 years old. Age-related increase in the portion of fibroblasts with...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Astragalus membranaceus Increases Leukocyte Telomere Length, but Does Not Suppress Development of Accelerated Senescence Signs in OXYS Rats
AbstractAstragalus membranaceus (AM) was used for millennia by traditional Chinese medicine to slow down aging and extend lifespan. It has been shown that AM can affect all key hallmarks of aging including compensating telomere shortening which is recognized as one of the most reliable biomarkers of aging. The telomere shortening in peripheral blood leukocytes is viewed as a promising biomarker in predicting the risk of age-related diseases as well as a biomarker of the effectiveness of treatment. However, findings from epidemiological studies on the links between leukocyte telomere length (LTL) and age-related diseases ar...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Comparative Analysis of Quality of Life and Attachment Style among Cancer and Dementia Informal Caregivers
AbstractTo record and compare the quality of life and attachment style of dementia and cancer caregivers. This is a comparative prospective cross sectional study. Participants were 45 caregivers of patients with cancer and 45 caregivers of patients with dementia. The study was conducted at a University Hospital and from a Day Centre of Alzheimer Disease and related disorders Association in Athens. Quality of caregivers ’ life was measured by the Short Form 36 Health Survey Questionnaire (SF-36) and caregivers’ attachment was evaluated by the Experience in Close Relationships—Short Form (ECR). Caregivers’ age (cance...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Abuse and Neglect of Community-Dwelling Older Adults: Index Generation, an Assessment of Intensity, and Implications for Ageing in Place
This study provides a protocol for generating an index from this tool and assessing the intensity of abuse and neglect. Implications for aging in place are also provided. This study adopted a cross-sectional study and an analysis of secondary data on 515 community-dwelling older adults aged 60 years or higher. Standards in the literature were followed to develop a protocol for generating an index and assessing the intensity of abuse and neglect. The abuse and neglect scale has index scores ranging between 1 and 33, which means that the average score from the index that indicates the intensity of abuse and neglect would fal...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Leukocyte Telomere Length and Response to Antiangiogenic Therapy in Patients with Neovascular Age-Related Macular Degeneration
AbstractAge-related macular degeneration (AMD) is becoming the leading cause of vision loss in people over 60 yr of age. The neovascular form of AMD (nAMD) is characterized by choroidal neovascularization (CNV), the main trigger of which is vascular endothelial growth factor (VEGF), the inhibition of which is the current standard of treatment. Significant variability of response to anti-VEGF therapy determines the relevance of the search for biological markers —prognostic criteria of treatment response. We analyzed the response of 110 nAMD patients to anti-VEGF therapy depending on the functional and anatomical parameter...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Modern Approach and Geriatric Aspects of Teaching Gerontostomatology in Training Specialists under the Specialty Program
AbstractThe strategy of dental care for older age groups is based not only on the priorities determined by the demographic situation (guided by its development and the epidemiologically justified need for dental care), but also on improving the effectiveness of care, which must be based on the results of evidence-based medicine, as well as a personalized approach, implemented through the competencies taught to gerontostomatology students at dentistry schools. The aim of the work is to create a modern methodological basis for teaching the section of gerontostomatology within the modern dentistry curriculum. Based on the stu...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Comparison of Older Primary Healthcare Workers with Non-Older Workers in Terms of Working Life, Quality of Life and Health Problems in Turkey
AbstractWith the rapid growth of aging all over the world, it was reported that the proportion of older workers in employment would increase. It was aimed to comparison of older primary healthcare workers with non-older workers in terms of working life, quality of life and health problems in Mugla, Turkey. This cross-sectional was conducted in primary healthcare workers in Mugla. In the study population of 176 workers, 171 were responded, 73 of them were older and 98 of them were non-older workers. Older and non-older healthcare workers were compared in terms of working life, quality of life and health problems. In terms o...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Perceptions of Caregiving by Family Caregivers of Older Adults with Dementia in Iran: A Qualitative Study
AbstractThe concept of caring appraisal, which includes positive and negative aspects of care, has been considered as one of the key concepts in caregivers ’ studies and is affected by the knowledge, attitudes, values, beliefs, and social norms in their society. In this respect, the perception of family caregivers’ can be studied from a cultural perspective. The aim of the present study was to explore the self-appraisal concept of caring based on t he experience of family caregivers of older adults with dementia in Iran. In this qualitative study, data were collected through in-depth, semi-structured interviews. Twelve...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
The Quality of Life in the Elderly with Acquired Single-Sided Deafness
This study was aimed at assessing the negative impact of an acquired single-sided deafness on quality of life of the elderly. Prospective analysis of outpatient records was carried out to identify elderly patients with single-sided deafness using pure tone audiometry. The main inclusion criteria were age over 60, a 90 dB or higher threshold of an affected ear, a 30 dB or less threshold of an intact ear, and an acquired single-sided hearing loss with sudden onset and a deafness duration of less than 5 years. Taking the inclusion criteria into account, two groups were formed: the main group with single-sided deaf patients (n...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
The Modeling of Productivity Level and the Comparability of Sport Evaluation Depending on an Athlete ’s Age
AbstractThroughout life, the human working capacity is variable. It is influenced by a wide range of factors, both external and internal, which are difficult to take into account in various studies. An approximation of the density function of the given distribution, based on the assumption of the random nature of the physical condition, depending on a number of different reasons, among competitors and the hypothesis of the asymmetric distribution of athletes ’ achievements at different ages, is formed. Optimum parameters of a log-normal distribution that describe the working capacity of a person according to age were det...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
The Effects of Physical Health and Functional Status on Cognitive Functions in Women at Ages of 55 –64 Years
AbstractCognitive impairment is one of the most common causes of reduced quality of life in elderly people. The aim of the study was to evaluate the impact of functional status, physical health, and cognitive functions in 55 –64 year old women. The study included 250 women at ages of 55–64 years (mean age 59.3 ± 2.9 years). The study analyzed socio-demographic and economic factors, as well as functional and cognitive status and looked into the presence and prevalence of geriatric syndromes and their association wit h social, demographic, and economic characteristics and risk factors for the development of chronic nonc...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
Interrelation of Changes in the Left Ventricular Myocardium and Evidence of Clinical and Laboratory Indicators in Chronic Kidney Disease of Elderly
AbstractThe incidence of cardiovascular and kidney disease with age is growing steadily worldwide. The factors for cardiovascular and kidney diseases are similar at elderly ages. Left ventricular hypertrophy (LVH) in chronic kidney disease (CKD) at an elderly age is not well understood. The goal of this study was to examine changes in a structural state of the left ventricular myocardium depending on the severity of clinical and laboratory manifestations of CKD in elderly patients. Clinical, laboratory, and instrumental examination of 62 patients at ages of 60 to 74 years (the young old) was carried out; the average age wa...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
Depression Symptoms and Mortality in Elderly Peruvian Navy Veterans: A Retrospective Cohort Study
AbstractOur study was design to determine the association between depressive symptoms and mortality in adults over 60 years old Navy Peruvian Veterans. We performed a retrospective cohort study based on a previous cohort study. A total of 1681 patients over 60 years old were included between 2010 –2015. Demographic information, self-reported information about falls, physical frailty assessment, tobacco consumption, hypertension, Type 2 Diabetes Mellitus, Chronic Obstructive Pulmonary Disease and was collected. Depression was assessed by the short form of the Geriatric Depression Scale. We found that depressive symptoms w...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
Visually Impaired Older Adults as a Target Group of Social Rehabilitation: The Issue of the Peculiarities of their Lifestyle
This article presents materials of an empirical study of the peculiarities of the way of life of visually impaired older people in a social rehabilitation context. In comparison with older people without disabling visual impairments, the older blind and visually impaired, according to the results of this questionnaire survey, are characterized in terms of their position in society, the preservation of the “inner core” of the personality, involvement in social and cultural life, the need for novelty and expansion of “spiritual and cultural spaces,” creative activity, and social and cultural communication. (Source: A...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
Biological Age Estimation Based on the Spectral Analysis of the Bioelectrical Activity of the Human Brain
AbstractThis research offers a method of estimating human biological age based on the spectral analysis of the bioelectric activity of the brain for the first time. We have developed an IDC decentralization index, which is calculated by taking the total reduction of the background neurotrophic influences of the brain activating system on the peripheral tissues and organs into account. The obtained dependence of the IDC index on the age of healthy people at ages of 10 to 90, as well as on the degree of differentiation G1 –G4 of cancer cells, was close to linear. The accumulation of cell malfunctions and mutations with age...
Source: Advances in Gerontology - March 1, 2022 Category: Geriatrics Source Type: research
