On a New Paradigm of the Development of Neurodegenerative Diseases by the Example of Alzheimer ’s Disease and Parkinson’s Disease
AbstractThe role of neuronal inflammation developing during the formation of amyloid plaques and Lewy bodies is investigated. The influence of various exogenous and endogenous factors on the development of neuroinflammation is established, but the role of various infectious agents in the development of this process is much less studied. Today, the existence of a universal trigger mechanism of the neurodegenerative process is obvious: a specific pathogen of a bacterial or viral nature (including long-term persistent in nervous tissue in a latent state), reactivating, penetrates into certain cerebral structures, where it is ...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research

Effect on Physical Functions of Older Adults When Refraining from Going out due to COVID-19 Restrictions
AbstractThe study investigated the effect of refraining from going out during the coronavirus disease 2019 pandemic on physical function in community-dwelling older adults. The study included 49 patients who underwent home-visit rehabilitation. Four parameters of physical function —grip strength, five-times sit-to-stand test, single-leg stance test, and standing test for imbalance and disequilibrium (SIDE)—were assessed. They were evaluated before (March 2020) and after (May 2020) the state emergency was imposed, and the results were compared. The grip strength decreased significantly. A significant difference was also...
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research

Erratum to: Transport and Possible Outcome of Lipofuscin in Mouse Myocardium
An Erratum to this paper has been published: https://doi.org/10.1134/S2079057022310010 (Source: Advances in Gerontology)
Source: Advances in Gerontology - December 1, 2022 Category: Geriatrics Source Type: research

Noninvasive Methods for Studying Skin with Different Morphotypes of Aging
AbstractThe aim of this work is to estimate changes in the functional state of the microvasculature and to study the peculiarities of the morphological parameters of skin by noninvasive research methods with different morphotypes of aging. The study involves 55 individuals aged 35 –65 with involutional changes of the lower third of the face. Four morphotypes of aging are identified, depending on which patients are divided into the groups: the first group, 19 female patients with deformational type; second, 17 female patients with tired type; third, 8 female patients with fi ne-wrinkled type; and fourth, 11 female patient...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Retirement Resources Inventory —Scale Assessment, Relationship to Retirement Satisfaction, Adjustment and a Meta-Analytical Review
AbstractThe Retirement Resources Inventory (RRI) created by C.S. Leung and L.K. Earl is a frequently used self-reported scale for measuring retirement resources. Since it was introduced, 10 scientific papers have been published using the full set of questions and 3 papers using only some of the questions. These have produced ambiguous and inconsistent results with considerable differences in almost all the parameters measured between countries. This paper aims to conduct a systematic review of the scale ’s psychometric characteristics and examine the meta-analytic relationship to retirement adjustment, satisfaction and v...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Forecasting the Number of Grandparents in Russia under Conditions of Limited Information Resources
AbstractThis paper considers grandparenthood as a mechanism for effective implementation of the resource potential of older people. We develop and implement a methodology for forecasting the number of Russian grandparents. It consists of two parts: a method for forecasting the number of grandparents in general and active grandparents (participating in the care for and upbringing of grandchildren) in particular. The two parts of the methodology use different sources of information and have specific characteristics described in detail in the paper. The application of these methods allow us to forecast a growth in the number ...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Peculiarities of the Innervation of Epicardial Adipose Tissue in a Rat with Aging (Immunohistochemical Study)
AbstractThe aim of the research is to study the structure, innervation, and state of epicardial adipose tissue of the aortic-pulmonary region of the heart in rats at the age of 3 –4 and 18–23 months using neural immunohistochemical markers. Using a complex of histological and immunohistochemical methods, different nervous apparatuses (ganglia, clusters of chromaffin cells, nerve trunks, nerve-fiber bundles, nerve plexuses, synaptic endings) with different mediators are d etected in lobules of white and brown adipose tissue of the base of the rat heart. It is established that parasympathetic and sympathetic postganglion...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Interrelation of MicroRNAs and Transposons in Aging and Carcinogenesis
We present the results of an analysis of data on the presence of common epigenetic changes during aging and carcinogenesis, associated with changes in the expression of microRNAs derived from transposons. We find that aging is characterized by changes in the expression of 21 specific transposon-derived microRNAs associated with the development of malignant neoplasms. Before us, evidence similar to ours on the relationship between the mechanisms of aging and carcinogenesis at the epigenetic level has not been presented. We hypothesize that one of the key mechanisms of aging is an imbalance in the programmed activation of mo...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Intraoperative and Early Postoperative Risk Factors for the Development of Acute Cerebrovascular Accident in Elderly Patients after Coronary-Artery Bypass Grafting
AbstractThis work presents data on the problem of ischemic heart disease, surgical myocardial revascularization, as well as the risk of developing acute cerebrovascular accident (ACVA) in elderly patients with coronary-artery bypass grafting (CABG). We conducted a study to identify risk factors for the development of ACVA in elderly patients. Predictors of ACVA development in the operative and early postoperative periods are identified. It is proven that the time of extubation, increased PCO2 levels, and hyperlactatemia are reliable intraoperative and early postoperative predictors of ACVA in elderly patients with CABG. Th...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Survey of Knowledge, Attitudes and Practice of the Elderly toward COVID-19 Pandemic in Al-Amara, Iraq
AbstractDuring the COVID-19 pandemic, elderly people (those aged 60 years and above) are more susceptible to coronavirus infection due to altered immune system response and a higher rate of underlying comorbidities. The purpose of present study was to identify of knowledge, attitudes and practices (KAP) of elderly people in Iraq toward COVID-19 disease as a vulnerable group and to found out relationship between elderlies ’ KAP and their socio-demographic data. An cross-sectional study 253 elderly people was carried out, through using a designed questionnaire. The data was analyzed using descriptive and analytical statist...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Involvement of Elderly People in the Processes of Modern Digital Transformations
AbstractThe results of the sociological study “Digital Technologies for Tomsk Elderly,” conducted in Tomsk (May 2021) using the focus-group-discussion methodology, are analyzed. The study shows that many elderly citizens have no psychological readiness and sustained motivation to integrate into digital reality. Causal relationships are iden tified between the multifaceted involvement of elderly citizens in society and their skills in mastering and using digital technologies that make people stronger and society as a whole more inclusive in the face of a digital future. Recommendations for involving older people, who ar...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Ontogenetic Principles of Accelerated Aging and the Prospects for Its Prevention and Treatment
This article examines the phenomenon of “intrauterine programming,” which largely determines the further life cycle and the likelihood of developing a number of age-associated pathological processes. The possibility of the formation of pathological (accelerated) aging at various stages of ontogenesis is discussed with the use of a lar ge amount of published material from the standpoint of modern science. The reasons, mechanisms and phenotypic manifestations of accelerated aging and the possibilities of the earliest, its diagnosis starting from the perinatal period, and prediction of age-associated pathologies are discu...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Relationship between Disease Avoidance and Attitudes toward Older People
AbstractNegative attitudes toward older people persist, leading to the neglect and marginalization of older adults ’ will. The social group of older people is often perceived as being overly associated with disease, and disease avoidance is related to negative attitudes. Meanwhile, people with higher disease avoidance tend to avoid others, not just older adults. Therefore, whether disease avoidance and attitud es toward older people have a significant relationship should be examined, even after controlling for attitudes toward general others (i.e., younger people) and other personality determinants of social interactions...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Structure and Main Stages of Long-Term State Support to Elderly Citizens
AbstractThis work deals with the problem of modeling the process of providing state support to elderly citizens. Its structuring is substantiated with the allocation of separate modules: functional stages and the respective specialized statuses of patients. The influence of the main groups of factors on the formation of personal packages of services, including medical, social, psychological and educational components, is considered. Implementation of the functions of systemic support for providing comprehensive medical, social and psychological care for citizens of the older generation for the identified functional stages ...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research

Gender and Age Related Macro- and Trace Minerals Estimation Survey among the European North Residents
AbstractA comparative analysis of the content of elements in hair of the residents of Karelia of different gender and age and of the deviation in the content from reference values typical for residents of the central part of the Russian Federation is carried out. Hair from the occipital part of the head, in which the content of 25 chemical elements is determined, are used as the biological object for elemental analysis. A four-point scale corresponding to the range of deviation of the content of macroelements and microelements from reference values is used to estimate the data obtained. Studying the elemental status in the...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research