Ontogenetic Principles of Accelerated Aging and the Prospects for Its Prevention and Treatment
This article examines the phenomenon of “intrauterine programming,” which largely determines the further life cycle and the likelihood of developing a number of age-associated pathological processes. The possibility of the formation of pathological (accelerated) aging at various stages of ontogenesis is discussed with the use of a lar ge amount of published material from the standpoint of modern science. The reasons, mechanisms and phenotypic manifestations of accelerated aging and the possibilities of the earliest, its diagnosis starting from the perinatal period, and prediction of age-associated pathologies are discu...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Relationship between Disease Avoidance and Attitudes toward Older People
AbstractNegative attitudes toward older people persist, leading to the neglect and marginalization of older adults ’ will. The social group of older people is often perceived as being overly associated with disease, and disease avoidance is related to negative attitudes. Meanwhile, people with higher disease avoidance tend to avoid others, not just older adults. Therefore, whether disease avoidance and attitud es toward older people have a significant relationship should be examined, even after controlling for attitudes toward general others (i.e., younger people) and other personality determinants of social interactions...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Structure and Main Stages of Long-Term State Support to Elderly Citizens
AbstractThis work deals with the problem of modeling the process of providing state support to elderly citizens. Its structuring is substantiated with the allocation of separate modules: functional stages and the respective specialized statuses of patients. The influence of the main groups of factors on the formation of personal packages of services, including medical, social, psychological and educational components, is considered. Implementation of the functions of systemic support for providing comprehensive medical, social and psychological care for citizens of the older generation for the identified functional stages ...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Gender and Age Related Macro- and Trace Minerals Estimation Survey among the European North Residents
AbstractA comparative analysis of the content of elements in hair of the residents of Karelia of different gender and age and of the deviation in the content from reference values typical for residents of the central part of the Russian Federation is carried out. Hair from the occipital part of the head, in which the content of 25 chemical elements is determined, are used as the biological object for elemental analysis. A four-point scale corresponding to the range of deviation of the content of macroelements and microelements from reference values is used to estimate the data obtained. Studying the elemental status in the...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Accelerated Aging as a Risk of Education Digitalization: Possibilities for Prevention
AbstractThe work is devoted to analyzing the negative effects of digitalizing education and considering the possibilities for their prevention. The urgency of this problem under the current conditions of combating the novel-coronavirus-infection pandemic and moving a significant part of education and leisure to the virtual space is noted. A significant increase in the frequency of mental and physical maladjustment symptoms, a decrease in performance indicators and a deterioration of the biological-age parameters are recorded in participants in the experiment against the background of a deficit in physical activity and an i...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Transport and Possible Outcome of Lipofuscin in Mouse Myocardium
This study was performed to clarify the transfer and final end of lipofuscin substances that have been formed in cardiomyocytes. The hearts of BALB/c mice were obtained for resin embedding and ultra-thin sectioning. The specimens were observed under a transmission electron microscope, and the images were acquired using an XR401 side-insertion device. Lipofuscin granules are found abundantly in myocardial cells. Cardiomyocytes can excrete lipofuscin granules into the myocardial interstitium using capsule-like protrusions that are formed on the sarcolemma. These granules enter the myocardial interstitium and can be de-aggreg...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Telerehabilitation of Post-Stroke Patients with Motor Function Disorders: A Review
AbstractStroke is the main reason for disabilities of increasing geriatric population. It affects brain and motor function domains significantly reducing the life quality. Recent coronavirus pandemic raised a question on changing approaches to deliver post-stroke rehabilitation services to geriatric patients due to their high risk of serious illness. This paper presents an overview of current telerehabilitation approaches for motor function recovery and balance training of post-stroke patients. We used papers from peer-reviewed medical journals on stroke telerehabilitation. The review showed exergames, virtual reality (VR)...
Source: Advances in Gerontology - September 1, 2022 Category: Geriatrics Source Type: research
Design and Evaluation of an Educational Intervention to Prepare Close-to-Retirement Employees for Retirement
This study aimed to assess the effect of an educational intervention for preparing close-to-retirement employees for their retirement. This randomized pre/post interventional study was conducted among 140 employees of Kerman University of Medical Sciences. The 70 employees in the intervention group were educated in four 4 h sessions, including health, leisure time, and financial needs. The instrument used was the Retirement Syndrome Questionnaire. Findings show that feelings of helplessness and failure and oldness and idleness significantly decreased after the educational intervention, and feelings of effort and a new dire...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Is Ketogenic Diet Therapy a Remedy for Alzheimer ’s Disease or Mild Cognitive Impairments?: A Narrative Review of Randomized Controlled Trials
AbstractAlzheimer ’s disease (AD) is the most common form of dementia and is estimated to increase further due to the aging of the world population. Since preventive strategies or effective treatment for AD have not been defined yet, studies on metabolism and nutritional approaches have gained attention. A present literature review aimed to provide a summary of current evidence on the neuroprotective roles of ketogenic diets. A literature search was conducted on the MEDLINE, EMBASE, and CENTRAL databases for clinical trials that published in English and focused ketogenic therapy in AD or mild cognitive impair ment. The n...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Morphological Signs of Neurogenic Inflammation in the Heart of Rats during Aging
AbstractCellular changes in different parts of the heart of Wistar rats at the age of 18 –23 months are studied using histological methods of staining with toluidine blue, hematoxylin-eosin, and immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase (TH), and Iba-1 protein. Focal inflammatory infiltrates are found in the connective tissue of the heart base, near which PGP 9.5+ and TH+ plexuses consisting of parasympathetic and sympathetic nerve fibers are detected. In the area of the valvular heart apparatus and at the border between the fibrous ring and myocardium of the right atrium, the following path...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts
AbstractUltraviolet (UV) radiation is one of the main environmental factors leading to oxidative stress and accelerated skin aging. AEDG peptide, a regulator of pineal gland functions, has demonstrated geroprotective and antioxidant effects in in vivo and in vitro studies. The aim of this research was to evaluate the effect of AEDG peptide on the expression of genes encoding enzymes of the antioxidant system (NQO1, SOD1, CATALASE, and TRXR) in human skin fibroblasts in a model of accelerated aging induced by UV radiation. The expression ofSOD1 andTXNRD1 genes during UV-induced aging of dermal fibroblasts increases by 2 and...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Piezopulsometric Analysis of Autonomous Regulation of the Cardiovascular System in an Elderly Person under Stress
AbstractThe results of the application of a new method of arterial piezopulsometry for noninvasive assessment of the functional state and physiological mechanisms of autonomous regulation of the cardiovascular system (CVS) in an elderly person with acute pain associated with unexpected physical trauma are described. Such exposure caused a negative stress response in the muscle effectors (MEs) of CVS on the first day, provoking an abnormal increase and acceleration of LV myocardial contractility. Analysis of the arterial blood pressure pulse (PP) wave graphs shows that the maximum rate of PP growth,VmaxPP, reflecting the my...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Age-Associated Features of the Expression Level of Apoptosis Markers in Cardiomyocytes of Patients with Dilated Cardiomyopathy
AbstractTo understand the pathogenesis of dilated cardiomyopathy (DCMP), it is necessary to establish the molecular and cellular mechanisms of myocardial aging, including those associated with programmed cell death, the molecular mechanisms of which have not been extensively studied. The aim of this work is to study markers of apoptosis in cardiomyocytes of patients with DCMP in vitro. We used the method of primary dissociated cell cultures and the method of immunofluorescence confocal laser microscopy. Cells of the 3rd and 14th passages, corresponding to “young” and “old” cultures, were used to simulate cellular s...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Ageist Attitudes: Youth Identity, Subjective Time to Become Older, and Impressions of the General Older Population ’s Physical and Mental Health
This study examines the relationship between ageist attitudes and youth identity (the extent to which people feel they belong to the young population as opposed to the older population), and impressions of the physical and mental health of the general older population. The results of an online survey of Japanese participants (n = 474) showed that those with higher youth identity held stronger ageist attitudes. While impressions of the physical health of the general older population were not associated with ageist attitudes, participants with more positive impressions of older adults ’ mental health had weaker ageist atti...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
Experimental Studies of Geroprotective and Anti-Aging Effects of Chemical Compounds of Portulaca oleracea L. (Review)
AbstractThe analysis presented in the review of publications shows that extract ofPortulaca oleracea L. or its individual components (polysaccharides, oleracea, alkaloids tetrahydroisoquinoline operatein E) is able to increase the lifespan of laboratory animals, to activate telomerase and increase telomere length, and to provide antioxidant and antiosteoclastogenic impact. Various neuroprotective effects (improvement of memory and learning ability, inhibition of acetylcholinesterase, protection of dopaminergic neurons, improvement of motor functions, etc.) are of interest for the prevention of syndromes associated with age...
Source: Advances in Gerontology - June 1, 2022 Category: Geriatrics Source Type: research
