Simultaneous occurrence of transient global amnesia and Takotsubo syndrome triggered by caring for a terminally ill relative
Key Clinical MessageTakotsubo syndrome and transient global amnesia can occur simultaneously, not only in the context of acute but also long-standing emotional stress. Probably, hypothyroidism and migraine make the patient more susceptible to both of these disorders. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 25, 2024 Category: General Medicine Authors: Claudia St öllberger,
Josef Finsterer Tags: CASE REPORT Source Type: research
Impact of methimazole ‐induced hypothyroidism on postnatal swine
The objective of this study was to evaluate the impact of hypothyroidism induced with the antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for the duration of treatment but had only a transient effect on circulating thyroxine (T4). Thyroid tissue weight was significantly increased by more than 3.5-fold in response to MMI treatment. Histologically, the eosinophilic c olloid was largely absent from the thyroid follicle which displayed a disorganized columnar epithelium consistent with goiter. MMI induced hypothyroidism has no effect on growth rate over 28 d...
Source: Physiological Reports - April 25, 2024 Category: Physiology Authors: James C. Fazioli,
Margaret K. Mulligan,
Erin K. Ison,
J. Alex Pasternak Tags: ORIGINAL ARTICLE Source Type: research
Changes in biomarkers of the redox status in whole blood and red blood cell lysates in canine hypothyroidism
The objective of this study was to evaluate the changes in the redox status in canine hypothyroidism using whole blood (WB) and red blood cell (RBCs) lysates. For this purpose, a panel of five antioxidants and five oxidants biomarkers was measured in WB and RBCs lysates of 30 dogs with hypothyroidism, 26 dogs with non-thyroidal illnesses and 15 healthy dogs. The antioxidants measured were cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), thiol and paraoxonase type-1 (PON-1). Oxidants measured include the total oxidant status (TOS), peroxi...
Source: Veterinary Research Communications - April 25, 2024 Category: Veterinary Research Source Type: research
Primary Pituitary Abscess: Two Case Reports
Conclusion Pituitary abscess is a rare, potentially life-threatening disorder that may be easily mistaken for other sellar lesions. In this review, we contribute two additional cases of pituitary abscesses to increase awareness and emphasize the importance of proper diagnosis and management. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Journal of Neurological Surgery Reports)
Source: Journal of Neurological Surgery Reports - April 25, 2024 Category: Neurosurgery Authors: Ghosh, Sayak R. Pecorari, Isabella L. Funari, Abigail Ledet, Alexander J. Lally, Anne Karandish, Alireza Agarwal, Vijay Tags: Case Report Source Type: research
< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research
< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research
Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism
CONCLUSION: These experimental data supported a role for EIF4B function in the pathogenesis of the hypothyroid phenotype seen in CH patients. Our work indicated that EIF4B was identified as a novel candidate gene in CH. EIF4B is essential for animal survival, but further studies are needed to validate its role in the pathogenesis of CH.PMID:38654471 | DOI:10.1210/clinem/dgae270 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 24, 2024 Category: Endocrinology Authors: Feng Sun Rui-Jia Zhang Ya Fang Cheng-Yan Yan Chang-Run Zhang Feng-Yao Wu Rui-Meng Yang Bing Han Huai-Dong Song Shuang-Xia Zhao Source Type: research
Efficacy of a Telemonitoring System as a Complementary Strategy in the Treatment of Patients With Heart Failure: Randomized Clinical Trial
Comput Inform Nurs. 2024 Apr 24. doi: 10.1097/CIN.0000000000001115. Online ahead of print.ABSTRACTEpisodes of decompensation are the main cause of hospital admissions in patients with heart failure. For this reason, the use of mobile apps emerges as an excellent strategy to improve coverage, real-time monitoring, and timeliness of care. ControlVit is an electronic application for early detection of complications studied within the context of a tertiary university hospital. Patients were randomized to the use of ControlVit versus placebo, during a 6-month follow-up. The primary outcome was the difference in numbers of readm...
Source: Computers, Informatics, Nursing : CIN - April 24, 2024 Category: Nursing Authors: Diana M Achury-Salda ña Rafael A Gonzalez Angel Garcia Alejandro Mari ño Wilson R Bohorquez Source Type: research
Cases: Decompensated Heart Failure Secondary to Hypopituitarism in an Elderly Patient
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3491-24. Online ahead of print.ABSTRACTHypopituitarism is difficult to diagnose because of its non-specific symptoms, especially in the presence of comorbidities. A 77-year-old woman with worsening anorexia and exertional dyspnea was initially diagnosed with decompensated dry cold-type heart failure. Hormonal laboratory tests indicated secondary hypothyroidism as a part of the evaluation of heart failure. Furthermore, pituitary magnetic resonance imaging revealed thickening of the pituitary stalk and a loss of signal intensity in the posterior pituitary, thus suggestin...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Yoshino Yoshihiro Harano Toshiro Shibata Junko Shiroko Source Type: research
< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research
Experience With Bexarotene to Treat Cutaneous T-Cell Lymphomas: A Study of the Spanish Working Group of Cutaneous Lymphomas
CONCLUSIONS: Our study confirms bexarotene is a safe and effective therapy for the long-term treatment of CTCL.PMID:38653368 | DOI:10.1016/j.ad.2024.04.017 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 23, 2024 Category: Dermatology Authors: R Izu-Belloso I Gainza-Apraiz P Ortiz-Romero O Servitje-Bedate R Fern ández de Misa-Cabrera Y Pe ñate-Santana B Hernandez-Machin T Estrach-Panella M Llamas-Velasco J I Yanguas-Bayona M Morillo-Andujar E Acebo-Mari ñas S Perez-Gala J C Armario-Hita P Sa Source Type: research
Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia
ConclusionsThis is the largest pediatric cohort with severe autoimmune primary hypothyroidism without goiter, but with pituitary hyperplasia in which significant growth impairment was the most evident presenting sign. AAT phenotype might be correlated with this specific clinical presentation. In youths with growth impairment, hypothyroidism should always be excluded even in the absence of clear clinical signs of dysthyroidism. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 23, 2024 Category: Pediatrics Source Type: research
EMAS position statement: Thyroid disease and menopause
Women experience menopause at a particular stage of their lifetime. On the other hand, subclinical hypothyroidism, mainly due to autoimmune thyroiditis, is a common endocrine disease in women during their reproductive years (the prevalence rate is 6 –10 %) [1] and is often present or arises during the menopausal transition. (Source: Maturitas)
Source: Maturitas - April 23, 2024 Category: Primary Care Authors: Gesthimani Mintziori, Stavroula Veneti, Kris Poppe, Dimitrios G. Goulis, Eleni Armeni, C. Tamer Erel, Ivan Fistoni ć, Timothy Hillard, Angelica Lindén Hirschberg, Blazej Meczekalski, Nicolás Mendoza, Alfred O. Mueck, Tommaso Simoncini, Petra Stute, Dor Tags: Original article Source Type: research
Risks of suboptimal and excessive thyroid hormone replacement across ages
ConclusionSuboptimal and excessive LT4 replacement of the preventable non-communicable disease hypothyroidism requires more focus from the healthcare system and from the global political systems to prevent the personally devastating and socioeconomically challenging consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 22, 2024 Category: Endocrinology Source Type: research
Identification of a Novel IGSF1 Variant in Two Malaysian Male Siblings with Central Hypothyroidism and Macroorchidism
J Clin Res Pediatr Endocrinol. 2024 Apr 22. doi: 10.4274/jcrpe.galenos.2024.2023-12-1. Online ahead of print.ABSTRACTIGSF1 mutation is the commonest cause of mild to moderate isolated central congenital hypothyroidism and has an X-linked recessive inheritance, primarily affecting males. Other notable clinical features are macroorchidism with delayed pubertal testosterone rise, large birth weight, increased body mass index, low prolactin, transient growth hormone deficiency and low prolactin. Two male siblings with central hypothyroidism were found to have a novel IGSF1 c.3467T>A variant that was likely pathogenic based ...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 22, 2024 Category: Endocrinology Authors: Yee Lin Lee Tzer Hwu Ting Chong Teik Lim Karuppiah Thilakavathy Nurul Huda Musa King Hwa Ling Source Type: research
