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Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research

Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?
AbstractPurpose of ReviewThis review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction.Recent FindingsThe VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions. Research has shown that a low-calorie, high-fat diet can affect thyroid hormone levels. Weight loss can also influe...
Source: Current Nutrition Reports - March 25, 2024 Category: Nutrition Source Type: research

The efficacy and safety of PD-1 inhibitor combined with TACE in the first-line treatment of unresectable hepatocellular carcinoma
In this study, thre patients with unresectable hepatocellular carcinoma were treated with PD-1 inhibitor combined with TACE to achieve good tumor reduction effect and underwent live r cancer resection surgery. For patients with unresectable hepatocellular carcinoma, whether in BCLC stage B or stage C, effective systemic therapy (PD-1 inhibitor) combined with local therapy (TACE) can achieve a high rate of tumor regression and objective response. Some patients may even pursue su rgical treatment opportunities, and the treatment-related adverse reactions are controllable, which is expected to provide new options for extendin...
Source: Medical Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research

The global prevalence of sexual dysfunction in men with thyroid gland disorders: a systematic review and meta-analysis
Conclusionthe global prevalence of sexual dysfunction in men with TGD was found relatively high. also, the highest prevalence of sexual disorders was reported in hypothyroid cases. Thus, health policymakers are suggested to inform the individuals prone to this pathology regarding the negative effects of TGD on sexual dysfunction. Besides, TGD-affected cases can prevent sexual disorders and unpleasant consequences through timely medical treatments. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 25, 2024 Category: Endocrinology Source Type: research

Post-marketing surveillance of the safety and effectiveness of nivolumab for classic Hodgkin lymphoma in Japan
In conclusion, nivolumab showed a similar safety profile and comparable effectiveness to that reported in clinical trials for relapsed/refractory cHL (CheckMate 205, ONO-4538-15).PMID:38521840 | DOI:10.1007/s12185-024-03734-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 24, 2024 Category: Hematology Authors: Akira Kawasaki Kiyohiko Hatake Itaru Matsumura Koji Izutsu Tomohiro Hoshino Ayumi Akamatsu Akito Kakuuchi Kensei Tobinai Source Type: research

Immune-related adverse events associated with first-line immune checkpoint inhibitors for metastatic renal cell carcinoma: A systematic review and network meta-analysis
CONCLUSION: The analysis focused on the probability of irAEs occurrence in each system when mRCC patients were treated with different ICI-based therapies, potentially offering significant value for guiding clinical prevention, early diagnosis, and management of irAEs. The limitations of the study included the potential heterogeneity and low certainty of part of the evidence.PMID:38518592 | DOI:10.1016/j.intimp.2024.111884 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 22, 2024 Category: Allergy & Immunology Authors: Shan Wang Hongwei Lv Jing Yu Miao Chen Source Type: research

Sintilimab plus anlotinib as second or further-line therapy for extensive disease small cell lung cancer: a phase 2 investigator-initiated non-randomized controlled trial
This study is registered with ClinicalTrials.gov (NCT04055792).FINDINGS: Forty-two patients were enrolled between August 29, 2019 and December 26, 2021 at Henan Cancer Hospital in China. 37 patients were evaluable for efficacy. The median follow-up was 24.8 months (IQR: 16.9-28.2). The median PFS was 6.1 months (95% CI: 5.0-7.3). The OS was 12.7 months (95% CI: 7.1-18.2). The ORR was 56.8% (21/37, 95% CI: 40.0-73.5) and the DCR was 89.2% (33/37, 95% CI: 78.7-99.7). Forty patients (40/42, 95%) had at least one treatment-related adverse event (TRAE). Immune-related adverse events (irAEs) were reported in 39 patients (39/42, ...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Shuxiang Ma Zhen He Yang Liu Lili Wang Sen Yang Yufeng Wu Haiyang Chen Yingxi Wu Qiming Wang Source Type: research