Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Air Pollution Implicated as a Contributing Cause of Numerous Age-Related Conditions
A compelling range of evidence links greater particulate air pollution to a greater incidence of age-related disease and mortality. The primary mechanism is considered to be induction of chronic inflammation via the interaction of particulates with lung tissue. Constant, unresolved inflammatory signaling is disruptive to cell and tissue function throughout the body, accelerating the onset and progression of all of the most common disabling and ultimately fatal age-related conditions.
Growing evidence suggests that exposure to fine particulate matter (PM2.5) may reduce life expectancy; however, the causal pathways ...
Source: Fight Aging! - January 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
5 Causes Of Low Blood Pressure You Might Not Know About
Conclusion
Low blood pressure, although often associated with a healthy cardiovascular system, can also indicate underlying health issues.
It is crucial to recognize that low blood pressure should not be disregarded, particularly when accompanied by symptoms or fluctuations.
This article explored the causes of low blood pressure, including cardiovascular conditions, hormonal imbalances, and neurological disorders.
Smart heart care, including the use of blood pressure monitors and natural supplements, was emphasized as a proactive approach to maintaining a healthy life.
Understanding the causes and implementi...
Source: The EMT Spot - June 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Clinical Examination of Cardiovascular System For Medical Students
Discussion on blood pressure is not included here as a separate topic is dedicated to it.
Though the most commonly examined pulse is the radial, to check some of the characteristics, a more proximal pulse like the brachial or carotid needs to be examined. Following parameters of the pulse are routinely documented: 1. The rate: Normal rate in adult is 60-100 per minute. It is higher in children. Younger the child, higher the pulse rate.
Rhythm: Regular and irregular rhythms are possible. Mild variation with respiration is called respiratory sinus arrhythmia, with higher rate in inspiration. Respiratory sinus arrhythmia may...
Source: Cardiophile MD - May 30, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Paper Strip Tests for Hypothyroidism
Student researchers at Rice University have developed a paper strip test for hypothyroidism, similar to those that are commonly used for COVID-19 testing. Babies with congenital hypothyroidism require prompt diagnosis and treatment, but in many parts of the world a lack of healthcare resources can mean that the condition can go undiagnosed for long periods, affecting a child’s development. This paper-based device may be well suited for large screening programs in such countries, as it is inexpensive and easy to use, requiring just a small drop of blood. The device consists of a wicking pad that is impregnated with antibo...
Source: Medgadget - May 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Pediatrics riceuniversity Source Type: blogs
15 Causes Of High Blood Pressure: Your Essential Guide To Navigating Hypertension Triggers
Conclusion
In conclusion, high blood pressure can go unnoticed until it causes serious health issues, making it crucial to understand its causes and take preventative measures.
Lifestyle factors, genetics, and medical conditions can contribute to high blood pressure, but maintaining a healthy weight, exercising regularly, reducing salt intake, eating a healthy diet, limiting alcohol consumption, and quitting smoking can help prevent it.
Additionally, smart blood pressure monitors and natural supplements can aid in managing blood pressure levels and promoting heart health.
By implementing these strategies and re...
Source: The EMT Spot - May 14, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Athletes Exhibit Half the Incidence of Hypertension in the General Population
Cardiovascular aging is greatly influenced by exercise and physical fitness, to the point at which one can point to physically active hunter-gatherer populations that exhibit very few of the common cardiovascular issues present in wealthier first world populations. Researchers here report on a study of cardiovascular aging in competitive athletic individuals, noting that they exhibit less than half of the risk of hypertension observed in the general population. This is one of many examples of the way in which athletes tend to be healthier than the average.
Master athlete is a term applied to individuals typically ...
Source: Fight Aging! - May 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An Unusual Bradycardia
==================================Case Presentation by KEN GRAUER, MD (5/5/2023): — Edits by Drs. Meyers& Smith ...==================================Dr. Smith was reading ECGs — and he sent myself and Dr. Meyers the tracing shown in Figure-1. At the time we did not yet know the history ...What do YOU think?Figure-1: The initial ECG in today ' s case. No history yet ...Our Initial Thoughts on the ECG in Figure-1:Dr. Meyers said the following: " I see 2 different atrial foci — one sinus and one ectopic. There is AV block — but unclear why. T...
Source: Dr. Smith's ECG Blog - May 5, 2023 Category: Cardiology Authors: ECG Interpretation Source Type: blogs
What is strange about this paroxysmal atrial fibrillation in an otherwise healthy patient? And what happened after giving ibutilide?
Conclusions.The efficacy of transthoracic cardioversion for converting atrial fibrillation to sinus rhythm was enhanced by pretreatment with ibutilide. However, use of this drug should be avoided in patients with very low ejection fractions. (N Engl J Med 1999;340:1849-54.) Smith comments from the full text: They included patients who had had a fib for less than 48 hours They excluded patients with a fib for longer than 48 hours unless they proved, by TE echo, to not have an atrial thrombus OR unless they anti-coagulated them for 3 weeks first *Therefore, our patients who have been in afib< 48 hours, or who h...
Source: Dr. Smith's ECG Blog - March 13, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Unconscious + STEMI criteria: activate the cath lab?
Case submitted and written by Dr. Mazen El-Baba and Dr. Evelyn Dell, with edits from Jesse McLarenEMS brought a John Doe, in his 30s, who was found in an urban forest near a homeless encampment on a cool fall day. There were no signs of trauma on scene or on the patient. EMS reported an initial GCS of 8 with pupils equal and reactive. The patient had a witnessed generalized tonic-clonic seizure leading to GCS 4.Vitals: HR 45; systolic BP was 110-120; irregular respiratory rate; oxygen saturation was normal; tympanic temperature 30; glucose was 6. In the resuscitation room, the patient had another seizure that stopped after...
Source: Dr. Smith's ECG Blog - January 21, 2023 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
What is pericardial effusion – Cardiology Basics
What is pericardial effusion – Cardiology Basics
Pericardial effusion is collection of fluid between the visceral and parietal layers of the pericardium. If the amount of pericardial fluid is large or there is a rapid increase in the amount of pericardial fluid, compression of the heart prevents its proper filling. This reduces cardiac output and causes hypotension and is known as cardiac tamponade.
Cardiac tamponade needs urgent pericardial aspiration or surgical drainage if the fluid is very thick. Very thick fluid can be there in purulent bacterial pericarditis. Sometimes it can be a hemopericardium due to bleedin...
Source: Cardiophile MD - October 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
How is thyroid linked to heart disease? Cardiology Basics
Disorders of thyroid gland can cause heart disease in multiple ways. Heart disease can occur with both hypothyroidism and hyperthyroidism. In hyperthyroidism, heart rate increases and there is a hyperdynamic circulatory state which can lead to high output cardiac failure. Unlike in the usual congestive heart failure in which the extremities are cold due to vasoconstriction, in heart failure due to hyperthyroidism, the extremities are warm. Instead of a low volume pulse in usual heart failure, thyrotoxic heart failure has a high volume pulse.
Another important cardiac problem in hyperthyroidism is atrial fibrillation with ...
Source: Cardiophile MD - October 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Is this Myo-pericarditis? Or OMI with subsequent pericarditis? Does the angiogram always explain the ECG findings?
Conclusion: Although at 1st glance, it looked like the ECG picture in Figure-1 might be suggestive of acute pericarditis — on further inspection, there are significant ECG features against the diagnosis of acute uncomplicated pericarditis.As per the superb discussion above by Dr. Smith — evolution of this case (including the ECG picture on serial tracings) — are consistent with what probably occurred in today ' s case, namely the combination of acute OMI from LCx occlusion, followed by development of post-infarction regional per...
Source: Dr. Smith's ECG Blog - June 11, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
Machine Learning Can Make Lab Testing More Precise
An analysis of over 2 billion lab test results suggests a deep learning model can help create personalized reference ranges, which in turn would enable clinicians to monitor health and disease better.Paul Cerrato, MA, senior research analyst and communications specialist, Mayo Clinic Platform and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.Almost every patient has blood drawn to measure a variety of metabolic markers. Typically, test results come back as a numeric or text value accompanied by a reference range which represents normal values. If total serum cholesterol level is below 200 mg/dl or...
Source: Life as a Healthcare CIO - October 21, 2021 Category: Information Technology Source Type: blogs
